A5070018905- Apelin-related biomedical research
- Neonatal Respiratory Health Research
- Sepsis Diagnosis and Treatment
- Respiratory Support and Mechanisms
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Nuclear Receptors and Signaling
- Cardiac Arrest and Resuscitation
- Immune Response and Inflammation
- Electrolyte and hormonal disorders
- Intensive Care Unit Cognitive Disorders
- Paraoxonase enzyme and polymorphisms
- Occupational and environmental lung diseases
- Hemodynamic Monitoring and Therapy
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Heparin-Induced Thrombocytopenia and Thrombosis
- Congenital Diaphragmatic Hernia Studies
- Pleural and Pulmonary Diseases
- Hormonal Regulation and Hypertension
- Nosocomial Infections in ICU
- Renal function and acid-base balance
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Advanced MRI Techniques and Applications
- Microscopic Colitis
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Adrenal Hormones and Disorders
Université de Sherbrooke
2016-2025
Centre Hospitalier Universitaire de Sherbrooke
2008-2024
Hôpital Fleurimont
2009-2017
Université des Sciences de la Santé
2010-2016
Imagerie et Cerveau
2015
Institut Universitaire de Recherche Clinique
2015
St. Joseph’s Healthcare Hamilton
2014
Hôpital du Sacré-Cœur de Montréal
2012
Miyazaki International College
2009
Fonds de Recherche du Québec - Santé
2008
To determine whether emergency colectomy reduces mortality in patients with fulminant Clostridium difficile-associated disease (CDAD), and to identify subgroups of more likely benefit from the procedure.Many hospitals Quebec, Canada, have noted since 2003 a dramatic increase CDAD incidence proportion cases severe enough require intensive care unit (ICU) admission. The decision perform an remains largely empirical.Retrospective observational cohort study 165 that required ICU admission or...
Macrophage migration inhibitory factor (MIF) is a pivotal regulator of the immune response. Neutralization or genetic deletion MIF does not completely abrogate activation responses, however, and receptor, CD74, produces more pronounced phenotype than deficiency. We hypothesized that these observations may be explained by second MIF-like ligand, we considered probable candidate to protein encoded homologous, D -dopachrome tautomerase (D-DT) gene. show recombinant D-DT binds CD74 with high...
ELABELA (ELA) was recently discovered as a novel endogenous ligand of the apelin receptor (APJ), G protein-coupled receptor. ELA signaling demonstrated to be crucial for normal heart and vasculature development during embryogenesis. We delineate here ELA's structure–activity relationships report identification analogue 3 (ELA(19–32)), fragment that binds APJ, activates Gαi1 β-arrestin-2 pathways, induces internalization similarly its parent peptide. An alanine scan performed on revealed...
Clara cell protein (CC-16, also designated CC-10) is synthesized by the bronchiolar epithelium and has been suggested as an inhibitor of phospholipase A2 (PLA2) activity. Therefore, CC-16 a candidate for controlling inflammatory events in lung. Because amounts function may be altered fibrosing lung diseases which injury reported, it was measured alveolar fluids sera. Secretory PLA2 activity influence on platelet-derived growth factor-induced human fibroblast chemotaxis cytosolic were...
Neutrophilic polymorphonuclears (PMNs) play an important role in the progression of sepsis-related inflammation and become highly activated by a wide array ligands on site. The triggering receptor expressed myeloid cells-1 (TREM-1) is recently described that has many effects human PMN. engagement TREM-1 PMN can induce phagocytosis, reactive oxygen species production release myeloperoxidase IL-8. LPS priming effect these functions. We show this paper Lyn, AKT, extracellular signal-regulated...
The pathophysiology of sepsis-induced myocardial dysfunction still remains controversial. Macrophage migration inhibitory factor (MIF) has recently been identified as a cardiac-derived depressant in septic shock. Putative mechanisms by which MIF affects cardiac function are unknown. In an investigation possible action, rat model endotoxin toxicity was designed using intraperitoneal (I/P) injection lipopolysaccharides (LPS) with or without coinfusion neutralizing anti-MIF isotypic-matched...
Abstract It has been shown that the functions and rescue from apoptosis by proinflammatory mediators of polymorphonuclear leukocytes (PMN) tend to diminish with aging. Here, we investigated role protein tyrosine phosphatases (PTP), especially Src homology domain-containing phosphatase-1 (SHP-1), in age-related, altered PMN under granulocyte macrophage-colony stimulating factor (GM-CSF) stimulation. The inhibition PTP suggested a differential effect GM-CSF on phosphatase activity modulating...
Apelin is the endogenous ligand of APJ receptor, a member G protein-coupled receptor family. This system plays an important role in regulation blood pressure and cardiovascular functions. To better understand its C-terminal Phe13 residue on binding, signaling, hypotension, we report series modified analogues which was substituted by unnatural amino acids. These modifications delivered new compounds exhibiting higher affinity potency to inhibit cAMP accumulation compared apelin-13. In...
Apelin-13 was recently proposed as an alternative to the recommended β-adrenergic drugs for supporting endotoxin-induced myocardial dysfunction. Since signals through its receptor (Apelin peptide jejunum) exert singular inotropic/vasotropic actions and optimize body fluid balance, this candidate pathway might benefit septic shock management. Whether newly discovered ELABELA (ELA), a second endogenous ligand of Apelin jejunum highly expressed in kidney, further improves cardio-renal...
Apoptosis(programmed cell death) is induced in pulmonary cells and contributes to the pathogenesis of acute lung injury septic humans. Previous studies have shown that nitric oxide (NO) an important modulator apoptosis; however, functional role NO derived from inducible synthase (iNOS) sepsis-induced apoptosis remains unknown. We measured a rat model Escherichia coli lipopolysaccharide (LPS)-induced sepsis absence presence selective iNOS inhibitor 1400W. Four groups were studied 24 h after...
Triggering receptor expressed on myeloid cell‐1 (TREM‐1) is a recently described that has many effects polymorphonuclear neutrophil (PMN), as the engagement of this PMN can induce phagocytosis, respiratory burst and degranulation. We studied aging TREM‐1 in human PMN. from elderly were found to have impaired response following engagement. Notably they not able modulate TREM‐1‐induced young did. could reverse survival incubation with LPS or GM‐CSF whereas it did young. The phosphorylation...