A5111140009- Malaria Research and Control
- COVID-19 epidemiological studies
- Digital Imaging for Blood Diseases
- Viral Infections and Outbreaks Research
- Computational Drug Discovery Methods
- Mosquito-borne diseases and control
- Diverse Scientific Research Studies
- Drug-Induced Hepatotoxicity and Protection
- Cannabis and Cannabinoid Research
- HIV/AIDS drug development and treatment
- Food composition and properties
- Drug Transport and Resistance Mechanisms
- Parkinson's Disease Mechanisms and Treatments
- COVID-19 Clinical Research Studies
- Ethnobotanical and Medicinal Plants Studies
- Reproductive System and Pregnancy
- Ovarian function and disorders
- Advanced Chemical Sensor Technologies
- SARS-CoV-2 and COVID-19 Research
- Ruminant Nutrition and Digestive Physiology
- Data-Driven Disease Surveillance
- Pharmacological Effects of Natural Compounds
- Restless Legs Syndrome Research
- Probiotics and Fermented Foods
- Drug-Induced Ocular Toxicity
Nigerian Institute of Medical Research
2014-2025
Institut des Sciences Analytiques
2024
Université Claude Bernard Lyon 1
2024
University Hospitals of Leicester NHS Trust
2022
Lagos State Polytechnic
2021
Ekiti State University
2018
Antimalarial drug resistance has thrown a spanner in the works of malaria elimination. New drugs are required for ancillary support existing control efforts. Plasmodium falciparum requires host glucose survival and proliferation. On this basis, P . hexose transporter 1 ( Pf HT1) protein involved permeation is considered potential target. In study, we tested antimalarial activity some compounds against HT1 using computational techniques. We performed high throughput virtual screening 21,352...
A total of 42 growing rabbits different crossbreds with initial average weight 1.20kg were fed rations in wghuch rumen content (RC) and blood-rumen (BRC) proteins substituted for groundnut cake protein a completely randomized design. they grouped into 7 treatments 3 replicates, each containing 2 rabbits. They RC BRC practical diet at 10, 20 30% dietary inclusion levels 56 days. The daily feed intake(ADFI), gain (ADWG), conversion ratio (FCR) efficiency (PER) not significantly influenced...
Under-5 children have been known to bear a significant burden of malaria in endemic countries. Though progress has made towards prevention and control Nigeria, it is expected that the addition new strategy, such as perennial chemoprevention (PMC) can contribute more rapid decline cases. This study aimed determine prevalence factors associated with anaemia among aged 2–18 months Osun State. A cross-sectional household malariometric was conducted 80 communities across eight Local Government...
The burden of malaria persists in sub-Saharan Africa and the emergence artemisinin resistance has introduced complexity to control efforts. Monitoring efficacy artemisinin-based treatment for is crucial address this challenge. This study assessed artemether-lumefantrine (AL) genetic diversity Plasmodium falciparum isolates a Nigerian population.
New chemical entities are consistently being investigated in antimalarial drug discovery and they require animal models for toxicity efficacy testing. Murine searching novel drugs inevitable because show unique similarities to human physiology during malaria pathogenesis. Therefore, provide a preclinical basis (following vitro assessments of newly identified lead compounds) further assessment the development pipeline. Specific mouse strains, non-humanized humanized, have successfully been...
The relative antitrypanosomal and haemolytic activities of the methanol extracts 10 Nigerian medicinal plants comprising leaf, stem bark root Afzelia africana, Khaya senegalensis Terminalia superba as well leaf extract Lannea welwistchii were investigated. All showed varying degrees trypanocidal activity in vitro. roots T. K. senegalensis, A. africana most effective with a minimum lethal concentration (MLC) 3 mg/ml; compared to 5.4 mg/ml for diminazene aceturate (Berenil®), reference drug....
Objectives: Tardive dyskinesia (TD) unlike acute dystonia may be irreversible. This study investigated the effects of oral cannabidiol (CBD) on haloperidol-induced vacuous chewing movement (VCM) model TD. Methods: There were six experimental groups with different combinations 5 mg/kg haloperidol given orally. Behavioural assays and FBS measured. VCMs assessed after last dose medication. Blood for oxidative stress was collected 8th day administration Results: found that CBD co-administration...
Lime extracts of powdered combination seeds Picralima nitida, stem bark Alstonia boonei and leaves Gongronema latifolium is a common remedy used in the treatment malaria South Western Nigeria.To determine antiplasmodial activities combined herbal its impact on haematological, hepatological renological parameters mice.The 4-day suppressive curative tests were to assess extract mice infected with chloroquine-sensitive Plasmodium berghei at concentration 200mg/kg, 400mg/kg 800mg/kg body weight....
Malaria in pregnancy is one of the major causes mater nal morbidity and mortality as well poor outcomes. We studied knowledge, attitude practices pregnant women on malaria prevention, assessed their knowledge sulfadoxine-pyrimethamine (SP) for intermittent preventive therapy (IPTp-SP), used outcomes to create awareness prevention with IPTp-SP.
The SARS-CoV-2 virus is highly infectious resulting in increased infection and death among the front-line Healthcare Workers (HCW) because of limited access to personal protective equipment (PPE). This study assesses availability self-reported use PPE amongst HCW during COVID-19 pandemic Nigeria. A mixed-method was conducted through a cross-sectional survey in-depth interviews HCW. Quantitative data analysis done using SPSS version 26 thematic for interview. total 258 completed while 15 took...
Rampant chloroquine/hydroxychloroquine poisoning in Nigerian hospitals following suggestions of its possible efficacy the treatment and prevention newly emerged COVID-19 disease informed this survey.The aim study was to assess knowledge, attitude perception populace on use chloroquine pandemic.This cross-sectional done by administering an electronic questionnaire created using Google Docs, through social media cascade methods including WhatsApp application software capture data between April...
The decline in the efficacy of artemisinin-based combination treatment (ACT) some endemic regions threatens progress towards global elimination malaria. Molecular surveillance drug resistance malaria-endemic is vital to detect emergence and spread mutant strains. We observed 89 malaria patients for artemether-lumefantrine uncomplicated Plasmodium falciparum infections Lagos, Nigeria determined prevalence resistant strains population. Parasite clearance rates were by microscopy highly...
effective and safe means of sample collection is a crucial component testing for Covid-19. Uptake key to containing controlling the spread virus. Scientists have been working on various strategies that will increase uptake COVID-19. One such method involves use drive-through sampling strategy.data was collected by both qualitative quantitative methods. An eligibility form filled online. While in-depth interviews were conducted aspect study.2,600 visits recorded at website, 2300 (88.46%)...
Abstract Atypical antipsychotics, despite their rapid dissociation from dopamine receptors and reduced tendency to induce oxidative stress, have been associated with difficult-to-manage movement disorders, including tardive dyskinesia (TD). The study set out investigate the effects of cannabidiol (CBD), a potent antioxidant, on risperidone-induced behavioural motor disturbances; namely vacuous chewing movements (VCM), stress markers (e.g. superoxide dismutase (SOD), catalase (CAT),...
Malariometric surveys provide information on epidemiological parameters used in assessing malaria burden for evidence-based decision making. This study provides some malariometric indices two ecologically distinct areas Nigeria. The was conducted New Bussa Niger State (Sudan savannah) and Ijede Lagos (tropical rain forest). Study participants were screened malaria, fever, anemia their demographic characteristics recorded. A total of 1,648 (813 from 835 Ijede) recruited. Majority the age...
To formulate and evaluate microspheres of the antiretroviral drugs maraviroc tenofovir intended for a candidate vaginal microbicide assess its effect on lactic acid bacteria microflora.Ionic gelation technique was used to with subsequent characterization. The varying concentrations polymer, crosslinking agent curing time outcome variables viz: particle size, mucoadhesion encapsulation efficiency were investigated. Lactic isolated from vagina healthy women using standard microbiologic...
There are genuine concerns that long-term use of anti-retroviral drugs may be associated with reproductive complications in females. This study aimed to ascertain the effect highly active on ovarian reserve and potential female Wistar rats by extension HIV-positive human females.A total 25 rats, weighing between 140g 162g, were randomly allotted into non-intervention intervention groups, receiving drugs, Efavirenz (EFV), Tenofovir Disoproxil Fumarate (TDF), Lamivudine (3TC), a fixed-dose...
Abstract Population-based study is known to be a very essential type of during and after pandemic or epidemic, as it provides crucial information on the incidence, prevalence, risk factors disease in question. There has been limited about challenges faced conducting such surveys Nigeria. In this paper, we will share our experience, describe population-based seroepidemiological COVID–19 Lagos, Some were peculiar specific Local Government Areas (LGAs) while others general. The include general...
Abstract Malaria chemotherapy has been plagued by parasite resistance. Novel drugs must be continually explored for malaria treatment. Plasmodium falciparum requires host glucose survival and proliferation. Protein involved in hexose permeation, P. transporter 1 ( Pf HT1) is a potential drug target. We performed high throughput virtual screening of 21,352 small-molecule compounds against HT1. The stability the lead compound complexes was evaluated via molecular dynamics (MD) simulation 100...
Abstract Objectives: We investigated the influence of oral cannabidiol (CBD) on vacuous chewing movements (VCM) and oxidative stress parameters induced by short- long-term administration haloperidol in a rat model tardive dyskinesia (TD). Methods: Haloperidol was administered either sub-chronically via intraperitoneal (IP) route or chronically intramuscular (IM) to six experimental groups only combination with CBD. VCM were assessed at different time points after last dose medication....