A5043367249- NF-κB Signaling Pathways
- Immune Response and Inflammation
- Antimicrobial Peptides and Activities
- Immune Cell Function and Interaction
- Renal and related cancers
- T-cell and Retrovirus Studies
- Psoriasis: Treatment and Pathogenesis
- Cytokine Signaling Pathways and Interactions
- Signaling Pathways in Disease
- CAR-T cell therapy research
- CRISPR and Genetic Engineering
- Lymphoma Diagnosis and Treatment
- Dermatology and Skin Diseases
- Pluripotent Stem Cells Research
University of Tübingen
2015-2020
Proinflammatory cytokine signaling in keratinocytes plays a crucial role the pathogenesis of psoriasis, skin disease characterized by hyperproliferation and abnormal differentiation infiltration inflammatory cells. Although IL-17A TNFα are effective therapeutic targets IL-36 has recently emerged as proinflammatory cytokine. However, little is known about its downstream transcriptional responses. Here, we found that exposure to induced expression IκBζ, an atypical IκB member specific...
Pluripotent stem cells must strictly maintain genomic integrity to prevent transmission of mutations. In human induced pluripotent (iPSCs), we found that genome surveillance is achieved via two ways, namely, a hypersensitivity apoptosis and very low accumulation DNA lesions. The threshold was mediated by constitutive p53 expression marked upregulation proapoptotic target genes the BCL-2 family, ensuring efficient iPSC removal upon genotoxic insults. Intriguingly, despite elevated...