A5102970624- RNA and protein synthesis mechanisms
- RNA modifications and cancer
- RNA Research and Splicing
- Bacterial Genetics and Biotechnology
- Bacteriophages and microbial interactions
- Genomics and Phylogenetic Studies
- Advanced Electron Microscopy Techniques and Applications
- Enzyme Structure and Function
- Viral Infections and Immunology Research
- Peptidase Inhibition and Analysis
- Electron and X-Ray Spectroscopy Techniques
- DNA and Nucleic Acid Chemistry
- Plant Virus Research Studies
- Cellular transport and secretion
- Toxin Mechanisms and Immunotoxins
- Receptor Mechanisms and Signaling
- Hepatitis C virus research
- Antimicrobial Peptides and Activities
- Photosynthetic Processes and Mechanisms
- Chemical Synthesis and Analysis
- Monoclonal and Polyclonal Antibodies Research
- Radioactive Decay and Measurement Techniques
- CRISPR and Genetic Engineering
- RNA regulation and disease
- Neuropeptides and Animal Physiology
Charité - Universitätsmedizin Berlin
2016-2025
Humboldt-Universität zu Berlin
2004-2025
Freie Universität Berlin
2017-2025
Wadsworth Center
1999-2018
Howard Hughes Medical Institute
1999-2018
New York State Department of Health
1999-2014
Max Planck Institute for Molecular Genetics
1994-2014
Max Planck Society
1994-2011
University at Albany, State University of New York
1999-2004
Technical University of Darmstadt
2004
Significance One of the most critical and complex steps protein synthesis elongation cycle is coupled translocation messenger (m)RNA A- P-site transfer (t)RNAs through ribosome, catalyzed by factor EF-G. This step involves large-scale molecular movements in including rotational body head 30S subunit. Previously, structures have been obtained for trapped intermediates containing a single tRNA. Here, we report cryo-EM structure an intermediate with both tRNAs. represents previously missing...