A5058696915- Systemic Lupus Erythematosus Research
- Autoimmune and Inflammatory Disorders Research
- Atherosclerosis and Cardiovascular Diseases
- Systemic Sclerosis and Related Diseases
- Inflammasome and immune disorders
- Spondyloarthritis Studies and Treatments
- Osteomyelitis and Bone Disorders Research
- Biomarkers in Disease Mechanisms
- Adipokines, Inflammation, and Metabolic Diseases
- Rheumatoid Arthritis Research and Therapies
- Liver Disease Diagnosis and Treatment
- Cytokine Signaling Pathways and Interactions
- Cerebrovascular and Carotid Artery Diseases
VA Nasonova Scientific Research Institute of Rheumatology
2022-2024
Systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) are immunoinflammatory rheumatic diseases (IRDs) associated with a high risk of developing cardiovascular (CVD). Despite advances in diagnostics therapy, the pathology is 1.8–2.8 times higher than individuals without autoimmune diseases, increased at an early stage disease, clinical activity, disease duration, need for hospitalization, mortality. According to modern data, CVD patients SLE RA considered consequence systemic...
The pathogenesis of immunoinflammatory rheumatic diseases (IRDs) is based on chronic inflammation, one the key mechanisms which may be abnormal activation macrophages, leading to further disruption immune system. aim – evaluate pro-inflammatory circulating monocytes in patients with IRDs. Material and methods . study included 149 participants: 53 rheumatoid arthritis (RA), 45 systemic lupus erythematosus (SLE), 34 scleroderma (SSc) 17 participants without IRD, aged 30 65 years. Basal...
Disorders of blood lipids and lipoproteins are a global problem high-risk factor for atherosclerosis in patients with rheumatoid arthritis (RA). This article presents data on the influence inflammation proatherogenic disorders lipid lipoprotein metabolism, an emphasis proinflammatory cytokines. It analyzes profile RA identifies need to study subfractions high-density their function reverse cholesterol transport as more promising direction clarifying cardiovascular risk. Depending type...
The development of subclinical atherosclerosis in patients with rheumatoid arthritis (RA) is associated chronic inflammation, one the key mechanisms which may be abnormal activation macrophages. Objective : To assess characteristics pro-inflammatory circulating monocytes early RA depending on presence carotid arteries. study included 60 (42 women and 18 men) without signs cardiovascular disease. Atherosclerotic vascular disease was diagnosed by identifying atherosclerotic plaques. Basal...
To evaluate the detection rate of subclinical carotid atherosclerosis in rheumatoid arthritis (RA) patients with low cardiovascular risk (CVR). The study included 182 RA CVR (mSCORE<1%) and no established diseases a control group comprising 100 people. Atherosclerotic lesion arteries was assessed using Doppler ultrasound determined by atherosclerotic plaque (ASP) - local increase thickness intima-media complex (IMT) >1.5 mm. Carotid ASP were observed more frequently than (17% versus 8%;...
Background Children and adolescents who suffered from the rare polygenic autoinflammatory disease such as multifocal non-bacterial osteomyelitis (NBO) can stay without specialized care for long time. Currently we don’t have standardized treatment these patients. Administration of Biologics (B) established on opportunity to diagnose juvenile idiopathic arthritis (JIA) or ankylosing spondylitis (JAS) in relation combination bone lesions with and/or axial skeleton damage. Objectives To describe...
Background Whole-body MRI (WB-MRI) has the potential to detect early or hidden signs of inflammation and seems be more informative test than X-ray ultrasound methods for bone joints diseases. WB-MRI is important identification asymptomatic areas that are not available clinical examination (sacroiliitis, TMJ). can become a tool monitoring progression disease efficacy therapy. There enough data knowledge about role in children with JIA. Objectives To evaluate results rheumatic diseases (RD)...