A5059004927- Advanced Breast Cancer Therapies
- Estrogen and related hormone effects
- Ferroptosis and cancer prognosis
- Mechanisms of cancer metastasis
- Bioinformatics and Genomic Networks
- Glutathione Transferases and Polymorphisms
- Cancer Mechanisms and Therapy
- Natural product bioactivities and synthesis
- Epigenetics and DNA Methylation
- Protein Degradation and Inhibitors
- Thyroid Cancer Diagnosis and Treatment
- Inflammatory mediators and NSAID effects
- Histone Deacetylase Inhibitors Research
- Radiomics and Machine Learning in Medical Imaging
- Immune cells in cancer
- MicroRNA in disease regulation
- Ginseng Biological Effects and Applications
- Flavonoids in Medical Research
- Metabolomics and Mass Spectrometry Studies
- Microbial Natural Products and Biosynthesis
- FOXO transcription factor regulation
- Traditional Chinese Medicine Analysis
- Cancer Genomics and Diagnostics
- Genetic factors in colorectal cancer
Nanjing University of Chinese Medicine
2019-2024
Triple-negative breast cancer (TNBC) is a highly heterogeneous subtype of cancer, showing aggressive clinical behaviors and poor outcomes. It urgently needs new therapeutic strategies to improve the prognosis TNBC. Bioinformatics analyses have been widely used identify potential biomarkers for facilitating TNBC diagnosis management.We identified analyzed their diagnostic prognostic values using bioinformatics approaches. Including differential expression gene (DEG) analysis, Receiver...
Traditional Chinese medicine (TCM) plays a vital part in cancer treatment due to its unique superiority. Huoxue Yiqi Recipe-2 (HYR-2) was supposed have therapeutic effect on lung cancer, which came from Ze Qi Decoction one of the four great classics TCM called "Synopsis Prescriptions Golden Chamber". Network pharmacology demonstrated that targets active components HYR-2 were significantly enriched signaling pathways, closely associated with non-small cell (NSCLC) and programmed death ligand...
Accumulating statistics have shown that liver cancer causes the second highest mortality rate of cancer-related deaths worldwide, which 80% is hepatocellular carcinoma (HCC). Given underlying molecular mechanism HCC pathology not fully understood yet, identification reliable predictive biomarkers more applicable to improve patients’ outcomes. The results principal component analysis (PCA) showed grouped data from 1557 samples in Gene Expression Omnibus (GEO) came different populations, and...
Lung cancer has become the leading cause of cancer‐related death worldwide. Oxidative stress plays important roles in pathogenesis lung cancer. Many natural products show antioxidative activities treatment. Zi Shen decoction (ZSD) is a classic prescription for treatment disease. However, its effect on lacks evidence‐based efficacy. In this study, we investigated anticancer effects ZSD vivo and vitro . Our results showed that oral administration suppressed Lewis (LLC) growth subcutaneous...
Histone deacetylase (HDAC) family can remove acetyl groups from histone lysine residues, and their high expression is closely related to the poor prognosis of hepatocellular carcinoma (HCC) patients. Recently, it has been reported play an immunosuppressive role in microenvironment, but little known about mechanism.Through machine learning, we trained verified prognostic model composed HDACs. CIBERSORT was used calculate percentage immune cells microenvironment. Based on co-expression...
Salvianolic acid A (Sal A) has a wide range of pharmacological activities. To date, there have been no systematic and detailed metabolite research data Sal after oral administration in vitro vivo. In this study, rapid method based on ultrafast liquid chromatography-quadrupole-time-of-flight mass spectrometry was developed to detect metabolites (human liver microsome, human intestinal microbiota, artificial gastric, juice) vivo (urine, plasma, feces, various organs collected normal rats...
Immunocheckpoint inhibitors have shown impressive efficacy in patients with colon cancer and other types of solid tumor that are mismatch repair-deficient (dMMR). Currently, PCR-capillary electrophoresis is one the mainstream detection methods for dMMR, but its accuracy still limited by germline repair (MMR) mutations, functional redundancy MMR system, abnormal methylation MutL Homolog 1 promoter. Therefore, this study aimed to develop new biomarkers dMMR based on artificial intelligence...