Background: The periodontal disease status of 320 dentate adults, diagnosed 23.7 years previously with Type 1 insulin dependent diabetes mellitus, was evaluated. These patients had been monitored at 2‐year intervals as part a large University Pittsburgh longitudinal study assessing the medical complications associated diabetes. Methods: During one their regularly scheduled examinations, group adult subjects (mean age 32.1 years) received examination comprehensive oral health assessment....

Two distinct etiologies of head and neck squamous cell carcinoma (HNSCC) have been proposed, DNA damage owing to tobacco alcohol exposure human papillomavirus (HPV) oncogene-mediated transformation. Common genetic alterations in HNSCC include TP53 mutations, 11q13 amplification (amp) CDKN2A/p16 mutations or promoter methlyation. However, HPV+ it is frequent observe wild-type expression p16. The relationship this unusual pattern with amp has not tested. In a retrospective study on 125...

Abstract – Objectives: The oral health of a large cohort adult insulin‐dependent diabetic patients (Type 1), diagnosed 24 years previously with juvenile onset, was comprehensively assessed. This paper describes the prevalence coronal and root caries in this Type 1 population evaluates demographic, dietary, behavioral, physiologic, salivary medical variables associated decayed filled surfaces crown (DFS) or (RDFS). Methods: diabetes mellitus subjects participating evaluation had been...

Oral squamous cell carcinoma (OSCC) develops along a multistep genetic pathway including loss of tumor suppressor genes and alteration oncogenes. We characterized seven OSCC lines by classical molecular cytogenetic analysis fresh adjacent oral mucosa corresponding to three the cytogenetics. observed homogeneously staining regions (hsrs) in four lines, at 11q13 11q23 an unidentified marker chromosome fourth. Amplification band occurs 30-60% head neck carcinomas. To determine whether INT2...

Abstract Objective : The oral health of an adult population previously diagnosed with juvenile onset insulin dependent‐diabetes was comprehensively assessed. goal this exploratory cross‐sectional evaluation to describe the characteristics related partial tooth loss and edentulism in subjects Type 1 diabetes mellitus. Methods An 406 mellitus subjects, who had been monitored for 6–8 years as part a University Pittsburgh longitudinal study medical complications associated diabetes, received...

Purpose. To investigate whether oral hygiene improves after persons with scleroderma received structured instructions and facial hand exercises.Methods. Seventeen a baseline dental evaluation including an examination for decayed or missing teeth, calculus, sites that bleed upon probing, measures of aperture, the Patient Hygiene Performance Index. Upper extremity functioning strength, joint motion, dexterity were also measured. Participants home program consisting patient education on...

The authors have developed and assessed 2 innovative, case-based, interactive training programs on substance abuse, one for health professional students alcohol primary care providers screening, brief intervention, referral to treatment (SBIRT). Both build skills in abuse SBIRT. Real-world effectiveness trials involving medical (n = 10) nursing 60) were completed; 65) are progress during 2011. Medical had similarly low baseline scores assessments that benefited from training: knowledge,...

Recent trends in obesity show that over two-thirds of US adults are considered at least overweight (body mass index, BMI≥25 kg/m2) and those, about one-third categorized as obese (BMI≥30 kg/m2). Physicians can address the health impacts obesity; yet research has suggested physicians-in-training frequently fail to recognize obesity, not properly educated regarding treatment options, spend relatively little clinic time treating obesity. Medical school is a unique opportunity this area need so...

New technologies such as virtual reality, augmented and video games hold promise to support enhance individuals in addiction treatment recovery. Quitting or decreasing cigarette alcohol use can lead significant health improvements for individuals, heart disease risk cancer risks (for both nicotine use), among others. However, remaining recovery from is a challenge most individuals.

Loss of heterozygosity (LOH) on chromosomes 3p and 9p has been documented in a variety malignancies, which suggests the presence tumor suppressor gene loci these chromosomes. We have studied 77 oral carcinomas for LOH using 16 microsatellite markers distributed over 5 human Fifty-five (71%) tumors showed at one or more loci. A significant proportion informative was observed 9p: 58% 48%, respectively. majority losses multiple both. Our results suggest that genes located short arms 3 9 may be...

Abstract: Objectives: The purpose of this study was to assess potential risk factors for the development poor oral hygiene and increased dental caries in individuals with scleroderma. Methods: Twenty‐two subjects scleroderma participated study. All were examined Patient Hygiene Performance (PHP) Index, which assesses extent plaque debris over a tooth surface. In addition, aperature, xerostomia dominant upper extremity strength, motion, skin thickness, dexterity measured. Results: None had...

Background Widespread vaping and e-cigarette use is a relatively new phenomenon. Youth peaked in 2019, with over 25% of high school students currently vaping. e-Cigarettes are used where smoking not permitted or as an alternative cessation treatment instead Food Drug Administration–approved options. Vaping has the potential to harm health, including causing adverse respiratory effects nicotine addiction. Health care professionals need skills training help their patients this evolving health...

AbstractRossie KM, Piesco NP, Charley MR, Oddis CV, Steen VD, Fratto J, Deng JS. A Monoclonal Antibody Recognizing Golgi Apparatus Produced Using Affinity Purified Material from a Patient with Connective Tissue Disease. Scand J Rheumatol. 1992; 21: 109–15.Serum antibodies recognizing the apparatus have been reported in patients connective tissue diseases, but little is known of their significance. Serum systemic lupus erythematosus patient polymyositis was found to high titers anti-Golgi...

The effect of a localized viral infection on the occurrence graft-vs.-host disease (GVHD) was examined in allogeneic rat bone marrow chimeras (ACI/LEW). Animals without clinical evidence GVHD, 62 days after transplant, were infected salivary and lacrimal glands with sialodacryoadenitis virus (SDAV), sacrificed 8–25 postinfection. Using established histologic criteria, GVHD found more frequently SDAV-infected than uninfected chimeras. Skin oral mucosa, tissues not by virus, showed no...

The purpose of this study was to determine whether the mucosal alterations dorsal rat tongue produced by Candida albicans infection were reversible upon treatment with antifungal drug ketoconazole. Following experimentally‐produced infection, 17 rats showed clinical evidence persistent lesions over a period 20 weeks. Eight these animals then treated ketoconazole daily for 2 weeks (20 mg/kg/day). Appropriate non‐infected controls and ketoconazole‐only also maintained. Five after treatment,...

Loss of heterozygosity (LOH) on chromosomes 3p and 9p has been documented in a variety malignancies, which suggests the presence tumor suppressor gene loci these chromosomes. We have studied 77 oral carcinomas for LOH using 16 microsatellite markers distributed over 5 human Fifty-five (71%) tumors showed at one or more loci. A significant proportion informative was observed 9p: 58% 48%, respectively. majority losses multiple both. Our results suggest that genes located short arms 3 9 may be...