A5089309255- Chinese history and philosophy
- Japanese History and Culture
- Tracheal and airway disorders
- Voice and Speech Disorders
- Airway Management and Intubation Techniques
- Head and Neck Anomalies
- Cleft Lip and Palate Research
- Tumors and Oncological Cases
- Classical Philosophy and Thought
- HIV/AIDS drug development and treatment
- Structural Engineering and Vibration Analysis
- HIV/AIDS Research and Interventions
- Head and Neck Surgical Oncology
- Philosophy and History of Science
- Religious Studies and Spiritual Practices
- Synthetic Organic Chemistry Methods
- Esophageal and GI Pathology
- Philosophy and Theoretical Science
- Structural Load-Bearing Analysis
- Civil and Structural Engineering Research
- Vietnamese History and Culture Studies
- Asymmetric Synthesis and Catalysis
- Emotions and Moral Behavior
- Epistemology, Ethics, and Metaphysics
- Linguistics and language evolution
East Carolina University
2011-2023
Detroit Medical Center
2020
Sinai Grace Hospital
2020
Hospital Kuala Lumpur
2019
University of South Florida
2016
University of Pennsylvania
1969-2011
Sunesis (United States)
2010
ChemBridge (United States)
2007-2009
Drexel University
2009
Pfizer (United States)
2001-2007
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHost-guest complexation. 48. Octol building blocks for cavitands and carcerandsLinda M. Tunstad, John A. Tucker, Enrico Dalcanale, Jurgen Weiser, Judi Bryant, C. Sherman, Roger Helgeson, Carolyn B. Knobler, Donald J. CramCite this: Org. Chem. 1989, 54, 6, 1305–1312Publication Date (Print):March 1, 1989Publication History Published online1 May 2002Published inissue 1 March 1989https://doi.org/10.1021/jo00267a015RIGHTS & PERMISSIONSArticle...
Several theories of emotion propose that emotional responses are largely determined by the way events appraised. To determine whether proposed dimensions appraisal consistent across cultures, 973 Ss from United States, Japan, Hong Kong, and People's Republic China were asked to describe experiences. Few differences between 3 cultures observed on more primitive (pleasantness, attentional activity, certainty, coping ability, goal/need conduciveness) 2 cognitively complex (legitimacy norm/self...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStereoselectivities of nucleophilic additions to cyclohexanones substituted by polar groups. Experimental investigation reductions trans-decalones and theoretical studies cyclohexanone reductions. The influence remote electrostatic effectsYun Dong Wu, John A. Tucker, K. N. HoukCite this: J. Am. Chem. Soc. 1991, 113, 13, 5018–5027Publication Date (Print):June 1, 1991Publication History Published online1 May 2002Published inissue 1 June...
The design and synthesis of a novel series potent cell permeable peptidomimetic inhibitors the human β-secretase (BACE) are described. These feature hydroxyethyl secondary amine isostere aromatic ring replacement for C-terminus. crystal structure BACE in complex with this inhibitor is also presented.
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHost-guest complexation. 49. Cavitands containing two binding cavitiesJohn A. Tucker, Carolyn B. Knobler, K. N. Trueblood, and Donald J. CramCite this: Am. Chem. Soc. 1989, 111, 10, 3688–3699Publication Date (Print):May 1, 1989Publication History Published online1 May 2002Published inissue 1 1989https://pubs.acs.org/doi/10.1021/ja00192a028https://doi.org/10.1021/ja00192a028research-articleACS PublicationsRequest reuse permissionsArticle...
More than 15 serially sectioned human embryos from stage 8 to were examined, together with relevant reconstructions and photographs. Their lengths ranged 1 7 mm, their ages 18 33 postovulatory days. The necessity of employing a recognized staging system is stressed. foregut appears either late in or during 9. median pharyngeal groove that 9 presages the first indication respiratory includes future larynx. laryngotracheal sulcus begins be circumscribed at 10 caudal expansion represents...
An overview of the developing laryngeal epithelium has been presented to establish norm. The sequential relationships formation protective covering, cellular and glandular, have reviewed. topographical distribution epithelial elements in human larynx are illustrated adult contrasted child. Unique previously undescribed ultrastructure transition areas identified. Biological integration form function is again well larynx.
A new practical flexible fiberoptic nasopharyngolaryngoscope is introduced. This instrument allows for a completeness of examination heretofore not totally possible in all cases as an office or bedside procedure. The ease and patient tolerance make superior clinical tool.
Oxazolidinones are a novel class of synthetic antibacterial agents active against gram-positive organisms including methicillin-resistant Staphylococcus aureus as well selected anaerobic organisms. Important representatives this include the morpholine derivative linezolid 2, which is currently in phase III clinical trials, and piperazine eperezolid 3. As part an investigation structure−activity relationships structurally related oxazolidinones, we have prepared evaluated properties series...
ABSTRACT Through broad screening of the compound library at Pharmacia, a naphthalene carboxamide was identified as nonnucleoside inhibitor human cytomegalovirus (HCMV) polymerase. Structure-activity relationship studies demonstrated that quinoline ring could be substituted for naphthalene, resulting in discovery 4-hydroxyquinoline-3-carboxamide (4-HQC) class antiviral agents with unique biological properties. In vitro assays 4-HQCs have potent inhibition HCMV, herpes simplex virus type 1...
3-Guanidinopropionic acid (1, PNU-10483) has been demonstrated to both improve insulin sensitivity and promote weight loss selectively from adipose tissue in animal models of non-insulin-dependent diabetes mellitus (NIDDM). However, 1 also shown be a substrate for the creatine transporter kinase, leading marked accumulation muscle as corresponding N-phosphate 4. In an effort identify novel entities that maintain antidiabetic potency without susceptibility creatine-like metabolism, analogue...
The crystal structures of many tertiary alpha-ketoamides reveal an orthogonal arrangement the two carbonyl groups. Based on hypothesis that alpha-ketoamide HIV attachment inhibitor BMS 806 (formally BMS378806, 26) might bind to its gp120 target via a similar conformation, we designed and synthesized series analogs in which ketoamide group is replaced by isosteric sulfonamide group. most potent these analogs, 14i, demonstrated antiviral potency comparable 26 M33 pseudotyped assay. Flexible...
Whole organ serial-section study contributes to our understanding of neonatal intubation injury by demonstrating the previously undescribed “V” configuration posterior cricoid lamina; this may be readily correlated with subarytenoid paramedian injury. This technique also permits detailed an anomalous larynx and precise identification a “tracheal” anomaly as malformation. The need for fetal staging system is reemphasized.
Inhibition of gamma-secretase presents a direct target for lowering Aβ production in the brain as therapy Alzheimer's disease (AD). However, is known to process multiple substrates addition amyloid precursor protein (APP), most notably Notch, which has limited clinical development inhibitors targeting this enzyme. It been postulated that APP substrate selective would be preferable non-selective from safety perspective AD therapy.In vitro assays monitoring inhibitor potencies at γ-site...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTQuantitative modeling of proximity effects on organic reactivityKendall N. Houk, John A. Tucker, and Andrea E. DorigoCite this: Acc. Chem. Res. 1990, 23, 4, 107–113Publication Date (Print):April 1, 1990Publication History Published online1 May 2002Published inissue 1 April 1990https://pubs.acs.org/doi/10.1021/ar00172a003https://doi.org/10.1021/ar00172a003research-articleACS PublicationsRequest reuse permissionsArticle...
ABSTRACT Neurogenic atrophy is described in biopsy specimens of laryngeal muscles seven large breed dogs. Signs shown by the dogs were similar but varied degree severity; most had a rough bark and stridorous respiration several months' duration which progressed to obstructive dyspnoea and, some cases, glottic obstruction with collaspe on exertion. At laryngoscopy, there signs both chronic acute laryngitis; vocal cords oedematous almost midline; they did not abduct vigorous inspiratory...