A5010179562- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- RNA Interference and Gene Delivery
- Circular RNAs in diseases
- Nanoparticle-Based Drug Delivery
- RNA modifications and cancer
- Supramolecular Self-Assembly in Materials
- Luminescence and Fluorescent Materials
- Nanoplatforms for cancer theranostics
- Molecular Sensors and Ion Detection
- Gastric Cancer Management and Outcomes
- Cancer Mechanisms and Therapy
- Monoclonal and Polyclonal Antibodies Research
- Signaling Pathways in Disease
- Immune cells in cancer
- GDF15 and Related Biomarkers
- Dental materials and restorations
- Bone and Dental Protein Studies
- Porphyrin and Phthalocyanine Chemistry
- Cancer, Lipids, and Metabolism
- Peptidase Inhibition and Analysis
- Advanced biosensing and bioanalysis techniques
- Inflammatory mediators and NSAID effects
- Collagen: Extraction and Characterization
- Cancer, Stress, Anesthesia, and Immune Response
Tongde Hospital of Zhejiang Province
2018-2022
State Key Laboratory of Supramolecular Structure and Materials
2009-2010
Jilin University
2009-2010
Two simple molecules, 1 and 2 with D-pi-A structure alkoxyl groups, respectively, were designed synthesized. Both compounds can gelatinize THF-water DMSO. And compound forms gel in acetone by ultrasonic stimulus. Interestingly, these gels exhibit aggregation-induced emission (AIE) during the sol-gel phase transformation. Moreover, molecular self-assembled photophysical properties be controlled number of chains type solvents. For example, has an identical packing model fluorescent colour DMSO...
Abstract Background Long noncoding RNAs (lncRNAs) are from the family of RNAs. Existing studies have shown that lncRNAs involved in many biological processes and strongly related to occurrence development tumors. Recent indicated lncRNA GIHCG participates progression cancers by adjusting cell proliferation migration. Gastric cancer (GC) is a prevalent malignant tumor arises gastric epithelium. This study mainly explored influence on GC its underlying mechanism. Methods expression was...
Aim: PD-L1 monoclonal antibody-conjugated miR-130a/oxaliplatin-loaded immunoliposomes were constructed for enhanced therapeutic efficacy against gastric cancer. Materials & methods: The in vitro antitumor of the was evaluated by cell viability, invasion, apoptosis and western blot analysis vivo a HGC27-bearing tumor xenograft model. Results: inhibitory role miR-130a demonstrated HGC27 cells downregulation RAB5A FOCL1 signaling pathways. Consequently, PD-miOXNP exhibited strongest anticancer...
Long non-coding RNAs (lncRNAs) have potential regulatory effects in oncogenesis. Previous studies showed that several lncRNAs could participate the progression of gastric cancer (GC). However, specific biological mechanisms GC are still unclear. We analyzed an lncRNA microarray and selected LINC01089 for study.
BACKGROUND Myosin phosphatase target subunit 1 (MYPT1) serves as a subgroup of myosin phosphatases, and is frequently low-expressed in human cancers. However, little known about the effects MYPT1 gastric cancer (GC). MATERIAL AND METHODS In our study, expression was detected by quantitative real-time reverse transcription PCR (qRT-PCR) GC tissues, different advanced pathological stages preoperative postoperative patients. Kaplan-Meier analysis used to measure overall survival analyzed...
miR-205 is a tumor suppressor and plays an important role in invasiveness. However, the of human gastric cancer (GC) epithelial-mesenchymal transition (EMT) remains unclear. The aim this study was to investigate molecular mechanism regulation EMT GC invasion.Quantitative polymerase chain reaction (qPCR) used detect expression GC. Further, correlation between pathological parameters prognosis statistically analyzed. A transwell model evaluate effect miR-205-3p on invasion migration cells....
Objective To investigate the prognostic significance of proteolysis-inducing factor (PIF) in gastric cancer patients. Methods Biopsies rectus abdominis muscle were obtained intra operatively from 53 patients and subjects undergoing surgery for benign abdominal diseases, serum PIF, ubiquitin expression, proteasome proteolytic activities assessed through reverse-transcription polymerase chain reaction (RT-PCR), Western blot, enzyme-linked immunosorbent assay (ELISA). Results PIF...
Objective:The aim of this study is to observe human dentin collagen fibrils with Atomic force microscopy (AFM) in air.Methods: Freshly extracted caries-free third molars were collected and stored normal saline at 4 ℃ until prepared.The midcoronal specimens sectioned wet polished through a series SiC papers, then the etched 10%(w/w) citric acid for 15s further treated an aqueous solution 10vol% NaOCl as deproteinizing agent 120s remove non-collagenous proteins.Subsequently, topography was...