A5064322618- Sulfur Compounds in Biology
- Nitric Oxide and Endothelin Effects
- Heart Rate Variability and Autonomic Control
- Cardiovascular Health and Disease Prevention
- Poisoning and overdose treatments
- Odor and Emission Control Technologies
- Blood Pressure and Hypertension Studies
- Lipid Membrane Structure and Behavior
- Esophageal and GI Pathology
- Air Quality and Health Impacts
- Signaling Pathways in Disease
- Foreign Body Medical Cases
- Calcium signaling and nucleotide metabolism
- Attention Deficit Hyperactivity Disorder
- Protein Interaction Studies and Fluorescence Analysis
- Child and Adolescent Health
- Electron Spin Resonance Studies
- Blood disorders and treatments
- Free Radicals and Antioxidants
- Asthma and respiratory diseases
- Substance Abuse Treatment and Outcomes
- Geochemistry and Elemental Analysis
- Cardiac Ischemia and Reperfusion
- Biochemical effects in animals
- Chemical Synthesis and Reactions
Comenius University Bratislava
1991-2021
Icahn School of Medicine at Mount Sinai
1994-1995
Antigen-specific activation of T lymphocytes, via stimulation the T-cell antigen receptor (TCR) complex, is marked by a rapid and sustained increase in concentration cytoplasmic free Ca2+ ([Ca2+]i). It has been suggested that second messenger inositol 1,4,5-trisphosphate (IP3) produced after TCR binds to IP3 (IP3R), an intracellular Ca(2+)-release channel, triggers [Ca2+]i activates transcription gene for growth factor interleukin 2 (IL-2). However, role IP3R signaling possibly plasma...
Background. Few epidemiological studies have investigated the problem of children and adolescents taken to hospital with acute alcohol intoxication. Methods. We reviewed medical records aged ≤ 18 years hospitalized intoxication alone in University Children's Hospital Bratislava, Slovak Republic, during 1996–2005 compared their characteristics between first second 5-year time periods. Results. 537 patients (273 boys 264 girls) were admitted intentional (1.5% all admissions 34.2%...
Frequent prescription of medication in an unapproved manner (off-label or unlicensed) the neonatal setting is a result limited availability adequately studied drugs pediatric population. Given that little information available on this issue from eastern European countries, purpose study was to describe for first time extent and pattern off-label unlicensed use medicines newborns Slovak Republic.Cross-sectional performed at Department Pathological Newborns Children's University Hospital,...
Doxycycline (DOXY) is an antibiotic routinely prescribed in human and veterinary medicine for antibacterial treatment, but it has also numerous side effects that include oxidative stress, inflammation, cancer or hypoxia-induced injury. Endogenously produced hydrogen sulfide (H2S) polysulfides affect similar biological processes, which reactive oxygen species (ROS) play a role. Herein, we have studied the interaction of DOXY with H2S (Na2S) (Na2S2, Na2S3 Na2S4) to gain insights into...
What is the central question of this study? Can cross-relationship between 35 rat arterial pulse waveform (APW) parameters be described by known mathematical functions and can obtained for conditions in a model hypertension resulting from decreased NO bioavailability? main finding its importance? Mathematical their were that approximate cross-relationships APW to systolic blood pressure augmentation index bioavailability. The results enable assigned bioavailability, which may have predictive...
What is the central question of this study? We wanted to find out whether relationship between rat arterial pulse waveform (APW) parameters and blood pressure could be described by known mathematical functions for conditions hypertension resulting from decreased NO bioavailability. main finding its importance? found their that approximate relationships 12 APW systolic diastolic in The results may assign bioavailability, which have predictive or diagnostic value. Information obtained useful...
This work is based on the hypothesis that it possible to characterize cardiovascular system just from detailed shape of arterial pulse waveform (APW). Since H2S, NO donor S-nitrosoglutathione (GSNO) and their H2S/GSNO products (SSNO−-mix) have numerous biological actions, we aimed compare effects APW find characteristic “patterns” actions. The right jugular vein anesthetized rats was cannulated for i.v. administration compounds. left carotid artery detect APW. From APW, 35 hemodynamic...
Analysis of acute clonazepam intoxications during the ten-year period 2001 - 2010 In article by (Rivotril) consulted with National Toxicological Information Centre (NTIC) in Bratislava years are analysed. 431 records were evaluated according to gender, age, cause, poisoning severity score and therapy. 57% all patients female, 42% male. The highest number, 123, was age between 19 35 117 36 50 years, most these cases suicidal attempts (85% 90%). Accidental common children under 5 (65 cases)....