A novel and efficient copper-catalyzed azidation reaction of anilines via C–H activation has been developed. This method, in which the primary amine acts as a directing group by coordinating to metal center, provides ortho products regioselectively under mild conditions. effective route for synthesis aryl azides is great significance view versatile reactivity azide products.

The Cu-catalyzed aerobic oxidative esterification of simple ketones via C–C bond cleavage has been developed. Varieties common ketones, even inactive aryl long-chain alkyl are selectively converted into esters. reaction tolerates a wide range alcohols, including primary and secondary chiral alcohols with retention the configuration, electron-deficient phenols, as well various natural alcohols. usage inexpensive copper catalyst, broad substrate scope, neutral open air conditions make this...

Abstract A cationic cobalt(III)‐catalyzed direct CH amidation of unactivated (hetero)arenes and alkenes by using 1,4,2‐dioxazol‐5‐ones as the amidating reagent has been developed. This transformation proceeds efficiently under external oxidant‐free conditions with a broad substrate scope. Moreover, 6‐arylpurine compounds, which often exhibit high potency in antimycobacterial, cytostatic, anti‐HCV activities, can be smoothly amidated, thus offering mild protocol for their late stage...

Alkene functionalization with a single-atom catalyst (SAC) which merges homogeneous and heterogeneous catalysis is fascinating route to obtain high-value-added molecules. However, C–N bond formation of alkene SAC still unexplored. Herein, bimetal-organic framework-derived Co–N/C an atomically dispersed cobalt center reported show good activity chemoselective aziridination/oxyamination reactions from hydroxylamine, late-stage complex alkenes diversified synthetic transformations the aziridine...

Emerging techniques are revolutionizing the realm of chemical synthesis by introducing new avenues for C–H bond functionalization, which have been exploited pharmaceuticals, natural compounds, and functional materials. Allylic oxidation alkenes serves as possibly most employed functionalization reaction. However, sustainable selective approaches remain scarce, majority existing conditions still hinge on hazardous oxidants or costly metal catalysts. In this context, we introduce a...

Abstract A novel copper‐catalyzed aerobic oxidative C(CO)C(alkyl) bond cleavage reaction of aryl alkyl ketones for CN formation is described. series acetophenone derivatives as well more challenging with long‐chain substituents could be selectively cleaved and converted into the corresponding amides, which are frequently found in biologically active compounds pharmaceuticals.

A novel I2-catalyzed direct conversion of cyclohexanones to substituted catechols under mild and simple conditions has been described. This transformation is remarkable with the multiple oxygenation dehydrogenative aromatization processes enabled just by using DMSO as solvent, oxidant, oxygen source. metal-free system demonstrates a versatile protocol for synthesis highly valuable therefore streamlines modification biologically important molecules drug discovery.

Abstract Novel nanostructured catalysts with highly dispersed cobalt have been synthesized by the pyrolysis of metal phenanthroline complexes. Materials significantly different properties were obtained simply tuning metal/ligand ratio. The catalytic potential this class compounds is shown first example dehydrogenation formic acid under catalysis atomically cobalt. From TEM, XPS, and XRD characterization, KSCN poisoning, leaching, formation CoN x species as active site seems key to success...

A novel Rh(III)-catalyzed C–H bond amination with the simultaneous release of a formyl group at distal positions is realized employing anthranil as new type reagent. This chemistry provides an efficient protocol for synthesis 2-acyl diarylamines, which are important structural motifs in many bioactive compounds. reagent possesses advantages high atom economy, avoids use external oxidants, and enables further transformation products.

A novel and efficient direct transformation of secondary bromides or olefins to highly value-added bromohydrins with DMSO has been disclosed.

Abstract C−N Bond formation is of great significance due to the ubiquity nitrogen‐containing compounds. Here, a mild and efficient Rh III ‐catalyzed C(sp 3 )−H aryl amination reaction reported. Anthranil employed as nitrogen source with 100 % atom efficiency. This C−H exhibits broad substrate scope without using any external oxidants. Mechanistic studies including rhodacycle intermediates, H–D exchange, kinetic isotope effect (KIE) experiments, in situ IR are presented.

A homogeneous manganese-catalyzed cross-coupling of two secondary alcohols for the divergent synthesis γ-disubstituted and β-disubstituted ketones is reported. Employing well-defined Mn-MACHOPh as catalyst, this novel protocol has a broad substrate scope with good functional group tolerance affords diverse library valuable disubstituted in moderate to yields. The strong influence reaction temperature on selective formation alcohol products was theorized preliminary DFT studies. Studies have...

The direct double dehydrogenation from primary amines to nitriles without an oxidant or hydrogen acceptor is both intriguing and challenging. In this paper, we describe a non-noble metal catalyst capable of realizing such transformation with high efficiency. A cobalt-centered N,N-bidentate complex was designed employed as metal–ligand cooperative catalyst. Detailed kinetic studies, control experiments, DFT calculations revealed the crucial hydride transfer, proton evolution processes....

Ironing it out: An efficient and convenient nitrogenation strategy involving CC bond cleavage for the straightforward synthesis of versatile arylamines is presented. Various alkyl azides alkylarenes, including common industrial by-product cumene, react using this protocol. Moreover, method provides a potential degradation polystyrene. Detailed facts importance to specialist readers are published as "Supporting Information". Such documents peer-reviewed, but not copy-edited or typeset. They...

A novel and highly-efficient N-heterocycle assembly methodology catalyzed by a cobalt- N , -bidentate complex via acceptorless dehydrogenation coupling of alcohols amines has been established.

The utilization of a single-atom catalyst to break C-C bonds merges the merits homogeneous and heterogeneous catalysis presents an intriguing pathway for obtaining high-value-added products. Herein, mild, selective, sustainable oxidative cleavage alkene form oxime ether or nitrile was achieved by using atomically dispersed cobalt hydroxylamine. Diversified substrate patterns, including symmetrical unsymmetrical alkenes, di- tri-substituted late-stage functionalization complex alkenes were...

A single-atom iron catalyst was found to exhibit exceptional reactivity in acceptorless dehydrogenative coupling for quinoline synthesis, outperforming known homogeneous and nanocatalyst systems. Detailed characterizations, including aberration-corrected HAADF-STEM, XANES, EXAFS, jointly confirmed the presence of atomically dispersed centers. Various functionalized quinolines were efficiently synthesized from different amino alcohols a range ketones or alcohols. The achieved turnover number...

Abstract A rhodium(III)‐catalyzed direct dehydrogenative annulation of benzamides with alkynes through chelating‐assisted CH activation has been developed. Naphthylamide and isoquinolinone derivatives can be chemoselectively obtained by this protocol.

An intermolecular nitrogenation reaction toward the synthesis of phenanthridines has been developed. This metal-free protocol provides a novel nitrogen-incorporation transformation using azides as nitrogen source. Phenanthridines, which are great interest in pharmaceutical and medicinal chemistry, synthesized efficiently one step. Moreover, byproducts derived from Schmidt inhibited, further demonstrated high chemoselectivity this transformation.

Molecular oxygen, the most environmentally friendly oxidant, was used as terminal oxidant for palladium-catalyzed radical oxidative acylation of arenes.