A5054796639- Neuroscience and Neuropharmacology Research
- Ion channel regulation and function
- Neuroinflammation and Neurodegeneration Mechanisms
- Micro and Nano Robotics
- Seaweed-derived Bioactive Compounds
- Bioactive natural compounds
- Molecular Communication and Nanonetworks
- Photoreceptor and optogenetics research
- Cardiac electrophysiology and arrhythmias
- Marine Invertebrate Physiology and Ecology
- Connexins and lens biology
- Neuroscience and Neural Engineering
- Pain Mechanisms and Treatments
- Phytochemistry and Bioactive Compounds
- Receptor Mechanisms and Signaling
- Ion Channels and Receptors
- Functional Brain Connectivity Studies
- Bioactive Compounds in Plants
- Memory and Neural Mechanisms
- Genomics, phytochemicals, and oxidative stress
- Medicinal Plant Pharmacodynamics Research
- Inflammation biomarkers and pathways
- Lipid Membrane Structure and Behavior
- Spaceflight effects on biology
- Sleep and Wakefulness Research
Korea Brain Research Institute
2017-2023
National Institute of Food and Drug Safety Evaluation
2023
Jeju National University
2011-2019
Aromatherapy massage is commonly used for the stress management of healthy individuals, and also has been often employed as a therapeutic use pain control alleviating psychological distress, such anxiety depression, in oncological palliative care patients. However, exact biological basis aromatherapy poorly understood. Therefore, we evaluated here effects interventions on multiple neurobiological indices quantitative assessments, electroencephalogram (EEG) power spectrum pattern, salivary...
Excessive microglial activation and subsequent neuroinflammation lead to synaptic loss dysfunction as well neuronal cell death, which are involved in the pathogenesis progression of several neurodegenerative diseases. Thus, regulation has been evaluated effective therapeutic strategies. Although dieckol (DEK), one phlorotannins isolated from marine brown alga Ecklonia cava, previously reported inhibit activation, molecular mechanism is still unclear. Therefore, we investigated here DEK via...
Functional restoration by the re-establishment of cellular or neural connections remains a major challenge in targeted cell therapy and regenerative medicine. Recent advances magnetically powered microrobots have shown potential for use controlled therapy. In this study, magnetic neurospheroid (Mag-Neurobot) that can form both structural functional with an organotypic hippocampal slice (OHS) is assessed using ex vivo model as bridge toward application. The Mag-Neurobot consists neurons...
Mitochondrial membrane potential (∆Ψ m ) contributes to determining a driving force for calcium enter the mitochondria. It has been demonstrated that even small mitochondrial depolarization is sufficient prevent overload and subsequent apoptosis. Therefore, mild recently evaluated as novel mechanism of neuroprotection via inhibiting neurotoxic during neuronal insults. In present study, using both real‐time recording flow cytometric analyses ∆Ψ , we ethanolic peel extract Citrus sunki Hort....
Hypoxia typically accompanies acute inflammatory responses in patients and animal models. However, a limited number of studies have examined the effect hypoxia combination with inflammation (Hypo-Inf) on neural function. We previously reported that neuronal excitability hippocampal CA1 neurons decreased during greatly rebounded upon reoxygenation. attributed this altered mainly to dynamic regulation hyperpolarization-activated cyclic nucleotide-gated cation (HCN) channels input resistance....
Abstract A‐type K + channels (I A channels) contribute to learning and memory mechanisms by regulating neuronal excitabilities in the CNS, their expression level is targeted Ca 2+ influx via synaptic NMDA receptors (NMDARs) during long‐term potentiation (LTP). However, it not clear how local changes induce I downregulation throughout neuron, extending from active synapse soma. In this study, we tested if two major of endoplasmic reticulum (ER), ryanodine (RyRs), IP 3 (IP R) receptors, are...
Abstract Oxidative stress causes neuronal cell death in various neurodegenerative diseases, such as Alzheimer’s disease, ischemia, and Parkinson’s disease. Therefore, reducing intracellular reactive oxygen species (ROS) has been evaluated an effective treatment strategy for disorders. Methyl lucidone (MLC) extracted from Lindera erythrocarpa Makino (Lauraceae) previously reported to exhibit microglial-mediated neuroprotective effects via inhibiting neuroinflammation. However, the antioxidant...
In this study, we introduce the importance of elevated membrane potentials (MPs) in prefrontal cortex (PFC) compared to that posterior parietal (PPC), based on new observations different MP levels these areas. Through experimental data and spiking neural network modeling, investigated a possible mechanism potential PFC how physiological differences affect dynamics cognitive functions PPC PFC. Our findings indicate NMDA receptors may be main contributor region highlight using modeling toolkit...
The downregulation of A-type K(+) channels (IA channels) accompanying enhanced somatic excitability can mediate epileptogenic conditions in mammalian central nervous system. As IA are dominantly targeted by dendritic and postsynaptic processings during synaptic plasticity, it is presumable that they may act as cellular linkers between responses under various excitable conditions. In the present study, we electrophysiologically tested if was sensitive to activities young hippocampal neurons....
Excessive influx and the subsequent rapid cytosolic elevation of Ca2+ in neurons is major cause to induce hyperexcitability irreversible cell damage although it an essential ion for cellular signalings. Therefore, most exhibit several mechanisms homeostatically regulate level normal as well pathological conditions. Delayed rectifier K+ channels (IDR channels) play a role suppress membrane excitability by inducing outflow various conditions, indicating their potential preventing pathogenic...
According to data from the national office of Statistics Korea and Ministry Health Welfare, as elderly population increases, dementia continues increase its future growth rate is expected be even faster. In particular, Dementia Management Act has been in effect since February 2012, active efforts made for a policy management. The purpose this study establish standards on building plans based appropriate scale spatial configuration facilities planning with dementia. Specifically, basic were...
Neurospheroid Microrobots In article number 2208747, Jong-Cheol Rah, Hongsoo Choi, and co-workers report on the development of a novel neurospheroid microrobot that features integration neurons magnetic nanoparticles. This enables precise delivery to target site through application an external rotating field, thereby offering potential platform for studying functional connectivity neuronal regeneration processes.
In an early developmental stage within postnatal 3 weeks, neurons in mammalian brains shows dynamic and rapid changes of prolein expression on cellular membrane, related with ion channels receptors. Using acute slices rat hippocampi (postnatal 7-21), change cell capacitance measured electrophysiologically during stages have been studied to find the correlation resting membrane potentials(RMP), which are decided by channel neuronal membrane. The RMP showed significant be hyperpolarized...
Hyperpolarization-activated, cyclic nucleotide-gated cation channels (HCN) encode hyperþolarization-activated current (Ih), playing regulatory roles in resting membrane properties, synaptic integration, and intrinsic exctabilities of hippocampal neurons. Expression patterns HCN subtypes seem to be quietty variable excitatory conditions neurons, even though it has been previously observed that expression levels HCN1, 2 4 are differentially regulated during developmental period. In the present...
Neuronal excitotoxicity induces mitochondrial dysfunction and the release of proapoptotic proteins.Excitotoxicity, process by which overactivation excitatory neurotransmitter receptors leads to neuronal cell death.Neuronal death was related degenerative disorders hypoxia, results from excessive exposure neurotransmitters, such as glutamate.Glutamate acts at NMDA in cultured neurons increase intracellular free calcium concentration.Therefore endogenous glutamate may be a key factor regulate...