A5101762040- Orthopaedic implants and arthroplasty
- Bone Tissue Engineering Materials
- Sarcoma Diagnosis and Treatment
- Anatomy and Medical Technology
- Pelvic and Acetabular Injuries
- Bone fractures and treatments
- Periodontal Regeneration and Treatments
- Down syndrome and intellectual disability research
- Alzheimer's disease research and treatments
- Magnesium Alloys: Properties and Applications
- 3D Printing in Biomedical Research
- Bone Tumor Diagnosis and Treatments
- Oral microbiology and periodontitis research
- Titanium Alloys Microstructure and Properties
- Mesenchymal stem cell research
- Surgical Simulation and Training
- RNA modifications and cancer
- Total Knee Arthroplasty Outcomes
- Surgical site infection prevention
- Colorectal Cancer Surgical Treatments
- Advanced Neural Network Applications
- Cancer-related gene regulation
- Coronary Interventions and Diagnostics
- HVDC Systems and Fault Protection
- COVID-19 diagnosis using AI
Shanghai Jiao Tong University
2021-2025
Shanghai Ninth People's Hospital
2021-2024
UK Dementia Research Institute
2023
University College London
2023
National Hospital for Neurology and Neurosurgery
2023
Background: Limited stem cells, low vascularization efficiency and weak osteoinductive activity plague the repair reconstruction of bone defects with cell-free scaffolds. Methods: Herein, injectable platelet-rich fibrin (i-PRF) was loaded into a methacrylated alginate/gelatin-methylcellulose (AGM) bioink system constructed porous hydrogel scaffold by three-dimensional bioprinting. The addition nanosilicate-laponite (Lap) further enhanced this synergized i-PRF to promote efficient...
Abstract Background and Objectives The treatment of pelvic tumors is widely recognized to be challenging. purpose this study was evaluate the efficacy personalized three‐dimensional (3D) printing‐based limb salvage reconstruction for tumors. Methods Twenty‐eight tumor patients were enrolled. 3D printing lesion models osteotomy templates prepared surgery planning, prosthesis design, assistance during surgery. prostheses manufactured used in all 28 patients. Follow‐up postoperative survival,...
The repair and reconstruction of bone defects are still major problems to be solved in the field orthopedics. Meanwhile, 3D-bioprinted active implants may provide a new effective solution. In this case, we used bioink prepared from patient's autologous platelet-rich plasma (PRP) combined with polycaprolactone/β-tricalcium phosphate (PCL/β-TCP) composite scaffold material print personalized PCL/β-TCP/PRP scaffolds layer by through 3D bioprinting technology. was then applied patient...
Cathepsin B is a cysteine protease that implicated in multiple aspects of Alzheimer's disease pathogenesis. The endogenous inhibitor this enzyme, cystatin (CSTB) encoded on chromosome 21. Thus, individuals who have Down syndrome, genetic condition caused by having an additional copy 21, extra the enzyme. Individuals syndrome are also at significantly increased risk developing early-onset (EOAD). impact CSTB development people not well understood. Here we compared biology cathepsin and had...
Osteoporotic fracture is one of the most serious complications osteoporosis. Most sites have bone defects, and restoring balance between local osteogenesis destruction difficult during repair osteoporotic defects. In this study, we successfully fabricated three-dimensional (3D)-printed biodegradable magnesium alloy (Mg-Nd-Zn-Zr) scaffolds prepared a zoledronic acid-loaded ceramic composite coating on surface scaffolds. The osteogenic effect Mg osteoclast inhibition acid were combined to...
Abstract The key to managing fracture is achieve stable internal fixation, and currently, biologically mechanically appropriate fixation devices are urgently needed. With excellent biocompatibility corrosion resistance, titanium–niobium alloys have the potential become a new generation of materials for fractures. However, role mechanism on promoting healing still undefined. Therefore, in this study, we systematically evaluated bone-enabling properties Ti45Nb via vivo vitro experiments. In...
Thus far, the hip revision surgery has been widely used and promoted, technology constantly innovated, such as tissue engineering, 3D printing prosthesis, etc. However, traditional standardized allograft, autograft, bone cement reinforcing ring are still main treatment methods in mainstream pelvic defects classification systems for revision. In addition, mainly focus on peri-acetabulum, but less large-scale complex that affecting regions far away from acetabulum, which also have a...
Stable fixation is crucial in fracture treatment. Currently, optimal devices with osteoinductivity, mechanical compatibility, and corrosion resistance are urgently needed for clinical practice. Niobium (Nb), whose properties similar to those of bone tissue, has excellent biocompatibility resistance, so it the potential be most appropriate material internal However, not much attention been paid use Nb area implants. Yet its role mechanism promoting healing remain unclear. Hence, this study...
Abstract Background With the development of medical technology, credible options for defect reconstructions after resection benign bone tumors lower extremities have become a high priority. As current reconstructive methods commonly used in clinical practice some flaws, new reconstruction need to be explored. We aimed prepare kind bioactive scaffold repair defects through stem cell rapid screening–enrichment–composite technology system developed by our team. Furthermore, we investigate...
<title>Abstract</title> <bold>Background:</bold> Three-dimensional (3D)-printed osteotomy guides and personalized 3D-printed prostheses have been used in pelvic tumor resection reconstruction, achieved good results. However, there is a lack of methods to evaluate its precision. This study aimed establish novel method the precision prosthesis installation using our 3D printing-based system surgeries. <bold>Methods:</bold> A retrospective analysis was conducted on 24 patients with malignant...
Abstract Cathepsin B is a cysteine protease that implicated in multiple aspects of Alzheimer’s disease pathogenesis. The endogenous inhibitor this enzyme, cystatin ( CSTB) encoded on chromosome 21. Thus, individuals who have Down syndrome, genetic condition caused by having an additional copy 21, extra the enzyme. Individuals syndrome are also at significantly increased risk developing early-onset (EOAD). impact development people not well understood. Here we compared biology cathepsin and...
Sarcomas are rare malignant tumors that may arise from anywhere of the body, such as bone, adipose, muscle and vascular. However, conventional pathogenesis sarcomas has not been found. Therefore, there is an urgent need to identify novel therapeutic strategies improve prognosis effects for sarcomas. Methylation N6 adenosine (m6A) regulation a proposed regulatory pattern works in post-transcription level, which was also most widely distributed methylation modification eukaryotic mRNA. Growing...
Abstract Background: With the development of medical technology, credible options for defect reconstructions after resection benign bone tumors lower extremities has become a high priority. As current reconstructive methods commonly used in clinical practice have some flaws, new reconstruction need to be explored. We aimed prepare kind bioactive scaffold repair defects through stem cell rapid screening–enrichment–composite technology system developed by our team. Furthermore, we investigate...
Abstract Purpose The blood vessel gives key information for pathological changes in a variety of diseases. In view the crucial role structure, present study aims to establish digital human standard model diagnosing vessel-related Methods recruited eight healthy volunteers, and reconstructed their bilateral upper extremity arteries according CTA. vessels were segmented, registered, merged into bunch. After being cut by continuous planes, dispersion bunches on each plane calculated. Results...