A5050268239- Clinical Nutrition and Gastroenterology
- Metabolism and Genetic Disorders
- Infant Nutrition and Health
- Folate and B Vitamins Research
- Diet and metabolism studies
- Muscle metabolism and nutrition
- Animal Nutrition and Physiology
- Nutrition, Genetics, and Disease
- Neonatal Respiratory Health Research
- Birth, Development, and Health
- Amino Acid Enzymes and Metabolism
- Body Composition Measurement Techniques
- Drug Transport and Resistance Mechanisms
- Nutrition and Health in Aging
- Breastfeeding Practices and Influences
- Aluminum toxicity and tolerance in plants and animals
- Childhood Cancer Survivors' Quality of Life
- Child Nutrition and Water Access
- Congenital Diaphragmatic Hernia Studies
- Intestinal Malrotation and Obstruction Disorders
- Pharmacological Effects and Toxicity Studies
- Boron Compounds in Chemistry
- Infant Development and Preterm Care
- Pneumonia and Respiratory Infections
- Pediatric Pain Management Techniques
Memorial University of Newfoundland
2014-2024
Sanofi (France)
2021
Université Paris Cité
2021
University of Guelph
2019
Queen's University
2013
Washburn University
2013
University of Toronto
1990-2009
University of Alberta
1999-2007
Food & Nutrition
1999-2003
McMaster University
1993-1998
ABSTRACT The vitamin D receptor (VDR) is expressed in human adipocytes and transiently induced during early adipogenesis mesenchymal progenitor cell models. VDR null mice exhibit enhanced energy expenditure reduced adiposity even when fed high fat diets. Adipocyte‐specific transgenic‐expression of enhances adipose tissue mass, indicating that activation lipid storage vivo. In these studies, we conducted genomic profiling differentiation assays primary cultures adipose‐derived cells to define...
Creatine (Cr) is an important high-energy phosphate buffer in tissues with a high energy demand such as muscle and brain consequently highly consumed nutritional supplement. synthesized via the S-adenosylmethionine (SAM) dependent methylation of guanidinoacetate (GAA) which not regulated by feedback mechanism. The first objective this study was to determine effectiveness GAA at increasing tissue Cr stores. Because SAM required for other reactions, we also wanted whether increased creatine...
The indispensability of arginine has not been conclusively established in newborns. Because parenteral feeding bypasses the gut (where de novo synthesis occurs from proline), a dietary supply that is sufficient to maintain urea cycle function may be greater importance during intravenous compared with enteral feeding. Two-day-old piglets ( n = 12) were fed nutritionally complete diets for 5 days via either central vein catheter (IV pigs, 6) or gastric (IG 6). Subsequently, each piglet...
We have previously shown that arginine deficiency is exacerbated by the removal of dietary proline in orally, but not parenterally, fed piglets. Therefore, we hypothesized net interconversions proline, ornithine, and primarily occur small intestine neonatal Ten intragastrically piglets received either intraportal (IP) or intragastric (IG) primed, constant infusions [guanido-(14)C]arginine [U-(14)C]ornithine + [2,3-(3)H]proline. By infusing amino acid isotopes via stomach compared with portal...
Empiric antibiotic therapy is often prescribed prior to the availability of bacterial culture results. In some cases, organism isolated may not be susceptible initial empiric (inadequate or IET). solid-organ transplant recipients, overall incidence and clinical importance IET unknown. We performed a retrospective cohort study patients admitted from 2002 2004. Multiple logistic regression analyses were conducted determine associations between potential determinants mortality. was administered...
Cytomegalovirus (CMV) retinitis is the most common cause of blindness in AIDS. Twenty patients were treated with a 21-day course foscarnet therapy by continuous infusion. Response to was good eight (47%) 17 evaluable patients; partial arrest progression observed (47%); and no response obtained one (6%). Foscarnet did not lead suppression urinary excretion CMV four 12 who nonetheless had improvement retinal lesions. Toxic effects, especially reversible renal failure, common, blood creatinine...
Arginine is conditionally indispensable in the neonate, and its synthesis intestine not sufficient to meet requirements. It known how neonatal endogenous arginine regulated degree which proline glutamate are used as precursors. Primed, constant intraportal intragastric infusions of L-[U-14C]proline L-[3,4-3H]glutamate, L-[guanido-14C]arginine were measure whole body first-pass intestinal 10 piglets fed generous (1.80 g.kg(-1).day(-1)) or deficient (0.20 quantities for 5 days. Glutamate...
Background : Successful small intestinal (SI) adaptation following surgical resection is essential for optimizing newborn growth and development, but the potential unknown. The authors developed an SI model in neonatal piglets supported by intravenous enteral nutrition. Methods Piglets (n = 33, 12–13 days old) were randomized to 80% with parenteral nutrition feeding (R‐PN), PN + (R‐EN), or sham transection (sham‐EN). In resected pigs, distal 100 cm of ileum (residual SI) 30 proximal left...
Creatine plays a significant role in energy metabolism and positively impacts anaerobic capacity, muscle mass, physical performance. Endogenous creatine synthesis requires guanidinoacetic acid (GAA) methionine. GAA can be an alternative to supplements has been tested as beneficial feed additive the animal industry. When pigs are fed with excess methionine, is synthesized without feedback regulation. In contrast, when dietary methionine limited, yet, does not accumulate plasma, urine, or...