A5009446651- Electrospun Nanofibers in Biomedical Applications
- Supramolecular Self-Assembly in Materials
- Bone and Dental Protein Studies
- Antimicrobial Peptides and Activities
- Drug Solubulity and Delivery Systems
- Bone Metabolism and Diseases
- Supercapacitor Materials and Fabrication
- RNA Interference and Gene Delivery
- Proteoglycans and glycosaminoglycans research
- Hydrogels: synthesis, properties, applications
- Intestinal and Peritoneal Adhesions
- Wnt/β-catenin signaling in development and cancer
- Intestinal Malrotation and Obstruction Disorders
- Cell Adhesion Molecules Research
- Mesenchymal stem cell research
- Helicobacter pylori-related gastroenterology studies
- Nanoplatforms for cancer theranostics
- Dental Trauma and Treatments
- Bone health and treatments
- Blood Coagulation and Thrombosis Mechanisms
- Aerogels and thermal insulation
- Wound Healing and Treatments
Shanghai Stomatological Hospital
2021-2025
Fudan University
2008-2025
Tongji University
2018-2021
Wuhan University of Science and Technology
2014
Abstract Background Unresolved inflammation and tissue destruction are considered to underlie the failure of dental pulp repair. As key mediators injury response, stem cells (DPSCs) play a critical role in repair regeneration. Resolvin E1 (RvE1), major dietary omega-3 polyunsaturated fatty-acid metabolite, is effective resolving activating wound healing. However, whether RvE1 facilitates injured pulp-tissue regeneration through timely resolution rapid mobilization DPSCs unknown. Therefore,...
Introduction: Cell-based tissue engineering is a promising method for dentin-pulp complex (DPC) regeneration. The challenges associated with DPC regeneration include the generation of suitable microenvironment that facilitates complete odontogenic differentiation dental pulp stem cells (DPSCs) and rapid induction angiogenesis. Thus, survival subsequent DPSCs are limited. Extracellular matrix (ECM)-like biomimetic hydrogels composed self-assembling peptides (SAPs) were developed to provide an...
Nanoporous activated carbon material was produced from the waste rice husks (RHs) by precarbonizing RHs and activating with KOH. The morphology, structure, specific surface area were investigated. nanoporous has average pore size of 2.2 nm high 2523.4 m 2 g −1 . capacitance is calculated to be 250 F at current density 1 A remains 80% for 198 20 electrode exhibits long‐term cycle life could keep stable till 10,000 cycles. consistently capacitance, rate capacity, ability makes it a potential...
Abstract Oral mucosal injuries are commonly caused by factors such as trauma, infection, or inflammation, especially in diabetic patients where healing is difficult and significantly affects quality of life. In this study, a nanocarrier system based on DNA tetrahedrons (TDN) developed, which serve ideal vectors due to their excellent intracellular uptake drug delivery capabilities. By efficiently delivering miR132 into cells, the proliferation migration human oral fibroblasts (HOMFs)...
The in situ gelation of injectable precursors is desirable the field tissue regeneration, especially context irregular defect filling. current driving forces for fast include phase-transition thermally sensitive copolymers, click chemical reactions with components, and metal coordination effect. However, rapid formation tough hydrogels remains a challenge. Inspired by aerobic metabolism, we herein propose tissue-fluid-triggered cascade enzymatic polymerization process catalyzed glucose...
The potential of guar gum as a film coating material for colon-specific delivery 5-fluorouracil is evaluated in this study. gum-based multi-unit pellet system prepared by and pH-sensitive polymer Eudragit FS30D sequentially around drug-loaded non-pareil cores fluid-bed coater. outer FS protects the against gastrointestinal environment dissolves rapidly distal small intestine, where lumen pH over 7 triggers dissolution enteric polymer. inner works time-controlled retardant offers additional...
Activation of the Wnt/β-catenin signalling pathway has been widely investigated in bone biology and shown to promote formation. However, its specific effects on osteoclast differentiation have not fully elucidated. Our study aimed identify role β-catenin osteoclastogenesis homeostasis.In present study, exon 3 gene (Ctnnb1) allele encoding phosphorylation target serine/threonine residues was flanked by floxP sequences. We generated mice exhibiting conditional activation...
Abstract The in situ gelation of injectable precursors is desirable the field tissue regeneration, especially context irregular defect filling. current driving forces for fast include phase‐transition thermally sensitive copolymers, click chemical reactions with components, and metal coordination effect. However, rapid formation tough hydrogels remains a challenge. Inspired by aerobic metabolism, we herein propose tissue‐fluid‐triggered cascade enzymatic polymerization process catalyzed...