A5044573364- Transcranial Magnetic Stimulation Studies
- Stroke Rehabilitation and Recovery
- Neuroscience and Neural Engineering
- EEG and Brain-Computer Interfaces
- Muscle activation and electromyography studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Advanced Neuroimaging Techniques and Applications
- Neurogenesis and neuroplasticity mechanisms
- Mitochondrial Function and Pathology
- Advanced MRI Techniques and Applications
- Spinal Cord Injury Research
- Traumatic Brain Injury Research
- Acute Ischemic Stroke Management
- Motor Control and Adaptation
- Functional Brain Connectivity Studies
- Botulinum Toxin and Related Neurological Disorders
- Neurological Disorders and Treatments
- Bone and Joint Diseases
- Neurological Disease Mechanisms and Treatments
- Nerve injury and regeneration
- Cerebral Palsy and Movement Disorders
- Pain Management and Treatment
- Thermal properties of materials
Medical University of South Carolina
2012-2021
Ralph H. Johnson VA Medical Center
2017-2021
National Institute of Neurological Disorders and Stroke
2020
University of Charleston
2019
Center for Neurosciences
2018
Queen Mary Hospital
2015
University of Hong Kong
2015
Illinois Wesleyan University
2013
The University of Texas at Austin
2003-2010
Malcom Randall VA Medical Center
2006-2008
The organization of forelimb representation areas the monkey, cat, and rat motor cortices has been studied in depth, but its characterization mouse lags far behind. We used intracortical microstimulation (ICMS) cytoarchitectonics to characterize general C57BL/6 cortex, more detail. found that region spans a large area frontal bordered primarily by vibrissa, neck, shoulder, hindlimb representations. It included caudal area, dominated digit representation, small rostral containing elbow wrist...
This study assessed the behavioral and dendritic structural effects of combining subdural motor cortical electrical stimulation with skills training following unilateral sensorimotor cortex lesions in adult male rats. Rats were pre-operatively trained on a skilled forelimb reaching task, Montoya staircase test, then received endothelin-1 induced ischemic cortex. Ten to 14 days later, electrodes implanted over peri-lesion surface. subsequently began 10 rehabilitative task 1 3 conditions: 1....
The complement system is implicated in promoting acute secondary injury after traumatic brain (TBI), but its role chronic post-traumatic neuropathology remains unclear. Using various injury-site targeted inhibitors that block different pathways and activation products, we investigated how involved neurodegeneration neuroinflammation TBI a clinically relevant setting of inhibition. current paradigm propagates post-TBI predominantly through the terminal membrane attack complex (MAC), focus has...
Diffusion MRI is a promising, clinically feasible imaging technique commonly used to describe white matter changes after stroke. We investigated the sensitivity of diffusion detect microstructural alterations in gray sensorimotor cortex stroke adult male rats.The mean diffusivity (MD) and kurtosis perilesional motor were compared with measures contralesional forelimb area at 2 hours, 24 72 or 25 days surgery. MD correlated surface densities glia, dendrites, axons.Perilesional was increased...
Cognitive deficits following traumatic brain injury (TBI) remain a major cause of disability and early-onset dementia, there is increasing evidence that chronic neuroinflammation occurring after TBI plays an important role in this process. However, little known about the molecular mechanisms responsible for triggering maintaining inflammation TBI. Here, we identify complement, specifically complement-mediated microglial phagocytosis synapses, as pathophysiological link between acute insult...
Behavioral experience can drive brain plasticity, but we lack sufficient knowledge to optimize its therapeutic use after stroke.We outline recent findings from rodent models of cortical stroke how experiences interact with postinjury events influence synaptic connectivity and functional outcome. We focus on upper extremity function.After unilateral infarcts, behavioral shape neuronal structure activity in both hemispheres. Experiences that matter include interventions such as skill training...
Background. The incidence of stroke in adulthood increases with advancing age, but there is little understanding how poststroke treatment should be tailored by age. Objective. goal this study was to determine if age and task specificity rehabilitative training affect behavioral improvement motor cortical organization after stroke. Methods. Young aged mice were trained proficiency on the Pasta Matrix Reaching Task prior lesion induction primary cortex endothelin-1. After a short recovery...
Following unilateral stroke, the contralateral (paretic) body side is often severely impaired, and individuals naturally learn to rely more on nonparetic side, which involves learning new skills with it. Such compensatory hyper-reliance “good” however, can limit functional improvements of paretic side. In rats, motor skill training forelimb (NPT) following a infarct lessens efficacy rehabilitative training, reduces neuronal activation in perilesion cortex. However, underlying mechanisms...
Motor rehabilitation after cerebral ischemia can enhance motor performance and induce map reorganization. Electrical stimulation of the cortex (CS) during rehabilitative training (CS/RT) augments plasticity confers gains in function beyond those observed with alone. However, it is unclear how distribution electrical across accomplishes these changes. This study examined behavioral neurophysiological effects delivering CS/RT through a distributed versus focal arrangement contacts.Adult male...
Background. Neuroplasticity and neurorehabilitation have been extensively studied in animal models of stroke to guide clinical rehabilitation patients. Similar studies focused on traumatic brain injury (TBI) are lacking. Objective. The current study was designed examine the effects individual combined rehabilitative approaches, previously shown be beneficial following stroke, an model moderate/severe TBI, controlled cortical impact (CCI). Methods. Rats received a unilateral CCI, followed by...
Because complement activation in the subacute or chronic phase after stroke was recently shown to stimulate neural plasticity, we investigated how and inhibition acute murine interacts with subsequent rehabilitation therapy modulate neuroinflammation remodeling. We additionally tissue plasminogen activator (tPA), other standard of care for stroke, a U.S. Food Drug Administration preclinical requirement translation an experimental therapy. CR2fH, injury site-targeted inhibitor alternative...