A5041662283- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Blood properties and coagulation
- Heavy Metal Exposure and Toxicity
- Trace Elements in Health
- SARS-CoV-2 and COVID-19 Research
- Inflammasome and immune disorders
- Venous Thromboembolism Diagnosis and Management
- Chromium effects and bioremediation
- Nanoparticles: synthesis and applications
- Dermatological and COVID-19 studies
- Mercury impact and mitigation studies
- Adipokines, Inflammation, and Metabolic Diseases
- Therapeutic Uses of Natural Elements
- COVID-19 epidemiological studies
- Rheumatoid Arthritis Research and Therapies
- Botulinum Toxin and Related Neurological Disorders
- Pharmaceutical and Antibiotic Environmental Impacts
- Antibiotic Resistance in Bacteria
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Bacterial biofilms and quorum sensing
- SARS-CoV-2 detection and testing
- Heavy metals in environment
- Vibrio bacteria research studies
- Arsenic contamination and mitigation
Stellenbosch University
2020-2025
University of Liverpool
2020-2023
Manchester University
2023
Weatherford College
2023
University of Pretoria
2013-2020
Department of Physiological Sciences
2020
Severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2)-induced infection, the cause of disease 2019 (COVID-19), is characterized by clinical pathologies, including various coagulopathies that may be accompanied hypercoagulation and platelet hyperactivation. Recently, a new COVID-19 phenotype has been noted in patients after they have ostensibly recovered from symptoms. This commonly termed Long COVID/Post-Acute Sequelae (PASC). Here we refer to it as COVID/PASC. Lingering symptoms...
Fibrin(ogen) amyloid microclots and platelet hyperactivation previously reported as a novel finding in South African patients with the coronavirus 2019 disease (COVID-19) Long COVID/Post-Acute Sequelae of COVID-19 (PASC), might form suitable set foci for clinical treatment symptoms COVID/PASC. A COVID/PASC Registry was subsequently established an online platform where can report previous comorbidities.
Severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2)-induced infection, the cause of disease 2019 (COVID-19), is characterized by unprecedented clinical pathologies. One most important pathologies, hypercoagulation and microclots in lungs patients. Here we study effect isolated SARS-CoV-2 spike protein S1 subunit as potential inflammagen sui generis. Using scanning electron fluorescence microscopy well mass spectrometry, investigate this to interact with platelets fibrin(ogen)...
Post-acute sequelae of COVID-19 (PASC), also now known as long COVID, has become a major global health and economic burden. Previously, we provided evidence that there is significant insoluble fibrin amyloid microclot load in the circulation individuals with these microclots entrap substantial number inflammatory molecules, including those might prevent clot breakdown. Scientifically, most challenging aspect this debilitating condition traditional pathology tests such serum CRP (C-reactive...
Progressive respiratory failure is seen as a major cause of death in severe acute syndrome coronavirus 2 (SARS-Cov-2)-induced infection. Relatively little known about the associated morphologic and molecular changes circulation these patients. In particular, platelet erythrocyte pathology might result vascular issues, manifestations may include thrombotic complications. These pathologies be both extrapulmonary intrapulmonary central to failure. Previously, we reported presence amyloid...
Type 2 Diabetes Mellitus (T2DM) is a well-known comorbidity to COVID-19 and coagulopathies are common accompaniment both T2DM COVID-19. In addition, patients with known develop micro-clots within the lungs. The rapid detection of uses genotypic testing for presence SARS-Cov-2 virus in nasopharyngeal swabs, but it can have poor sensitivity. A rapid, host-based physiological test that indicated clotting severity extent pathologies individual who was infected or not would be highly desirable.
Abstract Background: Fibrin(ogen) amyloid microclots and platelet hyperactivation are key pathological findings in patients with acute COVID-19 infection also those Long COVID/Post-Acute Sequelae of (PASC). These pathologies may represent a suitable target for pharmacological treatment COVID. Methods: Here we report on the symptoms displayed by cohort 91 South African COVID at baseline after clinician-initiated anticoagulant regime was completed. For laboratory analysis, provided blood...
<title>Abstract</title> BACKGROUND: The persistence of vasculo-thrombotic complications has been put forward as a possible contributing factor in the long COVID (LC) syndrome. OBJECTIVES: Given recently reported separate demonstration association LC with elevated levels fibrin amyloid microclots (FAM) and those neutrophil extracellular traps (NETs), markers that are linked to thromboinflammation, this study considers FAM NETs. RESULTS: results show NETs quantitatively structurally associated...
Introduction Rapid advances in personalized medicine and direct-to-consumer genomic applications could increase the risk that physicians will apply results inappropriately. To address a persistent lack of understanding genomics, we implemented pathology-supported genetic testing (PSGT) approach, guided by insights from clinician needs assessment conducted 2010. Methods Findings previous survey were used to develop new patient screening tool integrates non-communicable disease (NCD)...
Heavy metal pollution has increased in the last decades. Water sources are contaminated and human exposure is often long term to variable amounts of different metals. In this study, male Sprague-Dawley rats were exposed via oral gavage for 28 days cadmium (Cd) chromium (Cr), alone combination at concentrations 1000 times World Health Organization's acceptable water limits. Rat equivalent dosages used. Blood markers liver kidney function measured, changes cellular morphology was determined...
Abstract We recognise that fibrin(ogen) amyloid microclots and platelet hyperactivation, we have previously observed in COVID-19 Long COVID/Post-Acute Sequelae of (PASC) patients, might form a suitable set foci for the clinical treatment symptoms long COVID/PASC. first report on comorbidities found cohort 845 South African COVID/PASC patients who filled registry, which hypertension high cholesterol levels (dyslipidaemia) were most important comorbidities. The gender balance (70% female)...
Water contamination with metals due to anthropogenic activity is increasing and subsequent exposure increases the risk of associated toxicity. Exposure not limited a single metal but usually involves mixtures different at concentrations. Little known about contribution this type exposure, in humans, development non-communicable diseases such as cardiovascular disease, an increased thrombosis. The World Health Organization has established limits for levels drinking water includes copper (Cu),...
ABSTRACT Severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2)-induced infection, the cause of disease 2019 (COVID-19), is characterized by unprecedented clinical pathologies. One most important pathologies, hypercoagulation and microclots in lungs patients. Here we study effect isolated SARS-CoV-2 spike protein S1 subunit as potential inflammagen sui generis . Using scanning electron fluorescence microscopy well mass spectrometry, investigate this to interact with platelets...
Water contamination with heavy metals may adversely affect our health. High metal levels lead to changes in blood coagulation processes, increasing the risk for cardiovascular disease. Exposure is not limited a single but usually involves mixture of metals. In this study 24 male Sprague-Dawley rats were exposed cadmium (Cd) and mercury (Hg), alone combination, 28 days at dosages equivalent 1000 times World Health Organization water limits. Scanning electron microscopy analysis revealed that...
Abstract Bacterium Acinetobacter baumannii is a leading cause of hospital infections. Over the last decade, its occurrence in natural environments outside settings has been reported. The aim was to examine survival A. water media exposed different ranges oxygen supply order predict behaviour environment. abundance five isolates monitored nutrient-depleted and nutrient-rich aerated, intermediate anaerobic conditions (oxygen saturation 96, 56 0%, respectively). survived both all tested...
Abstract Psoriasis is a chronic, immune-mediated inflammatory skin disease, affecting approximately 2% of the general population, which can be accompanied by psoriatic arthritis (PsA). The condition has been associated with an increased cardiovascular burden. Hypercoagulability potential underlying mechanism that may contribute to risk major events in individuals. Whole blood samples were collected from 20 PsA patients and healthy concentrations molecules (C-reactive protein, serum amyloid...
ABSTRACT The prevailing hypotheses for the persistent symptoms of Long COVID have been narrowed down to immune dysregulation and autoantibodies, widespread organ damage, viral persistence, fibrinaloid microclots (entrapping numerous inflammatory molecules) together with platelet hyperactivation. Here we demonstrate significantly increased concentrations Von Willebrand Factor, factor 4,serum amyloid A, α-2antiplasmin E-selectin, endothelial cell adhesion molecule-1, in soluble part blood. It...
Abstract Background : Fibrin(ogen) amyloid microclots and platelet hyperactivation previously reported as a novel finding in South African patients with the coronavirus 2019 disease (COVID-19) Long COVID/Post-Acute Sequelae of COVID-19 (PASC), might form suitable set foci for clinical treatment symptoms long COVID/PASC. A COVID/PASC Registry was subsequently established an online platform where can report previous comorbidities. Methods: In this study, we on comorbidities persistent...
The risk of cardiovascular events in patients with Rheumatoid Arthritis (RA) is disproportionately heightened as a result systemic inflammation. relative effect autoimmune-associated citrullination on the structure and thrombotic potential fibrin(ogen) remains unknown. We therefore compared indices vascular function, inflammation, coagulation fibrin clot composition RA healthy controls evaluated parameter association disease presence. Blood samples were collected from 30 age- gender-matched...
Increased anthropogenic activity and subsequent environmental exposure to heavy metals induce the production of reactive oxygen species (ROS), which increases oxidative stress risk associated diseases. The aim this study, in a subacute model toxicity, was investigate effects copper (Cu), manganese (Mn), mercury (Hg) alone combination on liver tissue male Sprague-Dawley rats, exposed orally 100 times World Health Organization's acceptable water limits each metal. General histological...