Tea (Camellia sinensis) has been consumed for centuries as traditional medicine various diseases, including diabetes. The mechanism of action many medicines, tea, often requires elucidation. Purple tea is a natural mutant Camellia sinensis, grown in China and Kenya, rich anthocyanins ellagitannins. Here we aimed to determine whether commercial green purple teas are source ellagitannins teas, their metabolites urolithins have antidiabetic activity. Targeted UPLC-MS/MS was employed quantify...

Antibacterial activity of honey is due to the presence methylglyoxal (MGO), H2O2, bee defensin as well polyphenols. High MGO levels in manuka are main source antibacterial activity. Manuka has been reported reduce swarming and swimming motility Pseudomonas aeruginosa de-flagellation. Due complexity it unknown if this effect directly MGO. In ultrastructural investigation effects on morphology bacteria specifically structure fimbriae flagella were investigated. effectively inhibited Gram...

C-terminal amidation of antimicrobial peptides (AMPs) is a frequent minor modification used to improve antibacterial potency, commonly ascribed increased positive charge, protection from proteases, and stabilized secondary structure. Although the activity AMPs primarily associated with ability penetrate bacterial membranes, hitherto effect on this interaction has not been understood in detail. Here, we show that scorpion-derived membranolytic peptide AamAP1-Lys produces potent analog faster...

The rise in antimicrobial resistance has led to an increased desire understand how peptides (AMPs) can be better engineered kill antibiotic-resistant bacteria. Previously, we showed that C-terminal amidation of a peptide, identified scorpion Androctonus amoreuxi venom, its activity against both Gram-positive and -negative Here, incorporate all-atom molecular dynamics (MD) simulations rational design strategy create analogues A3a with greater therapeutic potential. We discover two novel AMPs...

This study investigated the potential health‐promoting properties of new sources natural food colorants, namely pigmented flower extracts from Geraniaceae ( Pelargonium grandiflorum, × hortorum, zonale hybrid) and Lamiaceae Salvia aurea dolomitica, dolomitica Plectranthus zuluensis ). In family, main phenolic acids identified were hydrolysable tannins, while flavonoids rutinosides kaempferol quercetin. caffeic acid its derivatives, naringin neohesperidin. The total polyphenol content (TPC)...

<italic>Ilex guayusa</italic>teas are a good source of dietary phenolic compounds with cellular antioxidant and anti-inflammatory properties comparable to green black<italic>Camellia sinensis</italic>teas.

Water contamination with metals due to anthropogenic activity is increasing and subsequent exposure increases the risk of associated toxicity. Exposure not limited a single metal but usually involves mixtures different at concentrations. Little known about contribution this type exposure, in humans, development non-communicable diseases such as cardiovascular disease, an increased thrombosis. The World Health Organization has established limits for levels drinking water includes copper (Cu),...

African green leafy vegetables (ALVs) are rich sources of nutrients and health-promoting bioactive metabolites that possess antioxidant, anti-inflammatory anticancer properties will assist in reducing the development noncommunicable diseases. Irrespective their reported properties, ALVs face challenges use food systems particularly mainstream markets/urban consumers due to poor insights lack knowledge on health benefits. Therefore, review aims at providing information promotes increased...

The metastatic behavior of melanoma has accentuated the need for specific therapy targets. Compounds, namely l-kynurenine ( l-kyn), quinolinic acid (Quin), and kynurenic (KA) previously displayed antiproliferative cytotoxic effects in vitro against cancer cells. Despite growing interest these compounds there are limited studies examining on melanoma. In B16 F10 cells, RAW 264.7 macrophage HaCat keratinocyte postexposure to compounds, crystal violet staining was used determine half-maximal...

Abstract Melanoma is an aggressive malignancy and remains a major cause of skin cancer mortality, highlighting the need for new treatment strategies. Recent findings revealed that L ‐kynurenine quinolinic acid induce cytotoxicity morphological changes in B16 F10 melanoma cells vitro. This paper highlights effects at previously determined half‐maximal inhibitory concentrations on cell cycle progression, death extracellular signal‐regulated protein kinase inhibition. Melanoma, murine...

Tick defensins may serve as templates for the development of multifunctional peptides. The purpose this study was to evaluate shorter peptides derived from tick defensin isoform 2 (OsDef2) in terms their antibacterial, antioxidant, and cytotoxic activities. We compared structural functional properties a synthetic peptide carboxy‐terminal parent (Os) that an analogue which three cysteine residues were omitted (Os–C). Here, we report both bactericidal (MBC values ranging 0.94–15 µg/ml)...

Antimicrobial peptides are small cationic that possess a large spectrum of bioactivities, including antimicrobial, anti‐inflammatory and antioxidant activities. Several antimicrobial known to inhibit lipopolysaccharide (LPS)‐induced inflammation in vitro protect animals from sepsis. In this study, the cellular anti‐endotoxin activities Os Os‐C, derived carboxy‐terminal tick defensin, were investigated. Both Os‐C found bind LPS , albeit lesser extent than polymyxin B melittin,...

Polyphenols are inversely associated with the incidence of chronic diseases, but therapeutic use is limited by poor stability and bioaccessibility. Encapsulation has been shown to overcome some these limitations. A selection polyphenols (catechin, gallic acid, epigallocatechin gallate) their combinations were encapsulated in beta-cyclodextrin (βCD). was characterized thermal storage evaluated using 2,2-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assay. The samples then subjected...

Heavy metals are natural elements characterized by their relatively large atomic mass as well high density. It can be introduced into the ecosystem mining of heavy from deep within earth's crust, thereby exposing air and water systems. Cigarette smoke is another source metal exposure has been shown to have carcinogenic, toxic genotoxic properties. Cadmium, lead, chromium most abundant found in cigarette smoke. In response tobacco exposure, endothelial cells release inflammatory...

Food-to-food fortification (FtFF) is gaining traction as a strategy to enhance nutritional value of cereal-based foods. Sorghum, major food crop for millions in the semi-arid tropics lends itself such FtFF efforts. Such food-to-food fortified (FtF fortified) foods also contain bioactive phenolics with health-promoting properties relation potential protection against diet-related non-communicable diseases (NCDs) whose prevalence increasing sub-Saharan Africa. In this study, effects extrusion...