A5006173875- Pharmacogenetics and Drug Metabolism
- Health Systems, Economic Evaluations, Quality of Life
- Biosimilars and Bioanalytical Methods
- Drug Transport and Resistance Mechanisms
- Phytochemicals and Antioxidant Activities
- Mass Spectrometry Techniques and Applications
- Metabolomics and Mass Spectrometry Studies
- Microencapsulation and Drying Processes
- Tea Polyphenols and Effects
- Analytical Chemistry and Chromatography
- Lipoproteins and Cardiovascular Health
- Antibiotics Pharmacokinetics and Efficacy
- Pharmacological Effects and Toxicity Studies
- Healthcare Policy and Management
- Food Security and Health in Diverse Populations
- Diabetes, Cardiovascular Risks, and Lipoproteins
University of Pretoria
2022-2024
Polyphenols are inversely associated with the incidence of chronic diseases, but therapeutic use is limited by poor stability and bioaccessibility. Encapsulation has been shown to overcome some these limitations. A selection polyphenols (catechin, gallic acid, epigallocatechin gallate) their combinations were encapsulated in beta-cyclodextrin (βCD). was characterized thermal storage evaluated using 2,2-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assay. The samples then subjected...
Abstract The physicochemical diversity of the structurally related aromatic probe drugs, used together in a drug cocktail to assess metabolic and transport phenotypes, require optimized analytical procedures for simultaneous quantification. conditions can greatly influence analyte selectivity, retention, stability, ultimately robustness method. aim this study was selectivity ionizable analytes between commonly C18 column chemistry an alternative biphenyl as well changes on method using...
Poor therapeutic outcomes have been attributed to inter-individual and interethnic variability in cytochrome P450 (CYP450)-dependent metabolism altered drug retention associated with P-glycoprotein (P-gp). An individualized pharmacotherapeutic approach would benefit the genetically diverse South African population. The study aim was develop a validated, targeted, analytical method quantify seven probe drugs their metabolites dried blood spots (DBS) using Mitra™ volumetric absorptive...
The recent substantial price reductions in insulin therapy by major manufacturers prompt an examination of their impact on South Africa (SA)'s healthcare. While Eli Lilly, Novo Nordisk, and Sanofi cut prices long-acting basal insulin, among others, significantly, these insulins are not SA's Essential Medicines List (EML) for primary With a high prevalence diabetes, especially pre-diabetes, the country, EML's neglect newer treatments hampers effective disease management. Despite efforts...