A5055813919- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Quinazolinone synthesis and applications
- Synthesis and biological activity
- Metal complexes synthesis and properties
- Computational Drug Discovery Methods
- Organometallic Complex Synthesis and Catalysis
- Ferrocene Chemistry and Applications
- Synthesis and Biological Evaluation
- Synthesis and Characterization of Heterocyclic Compounds
- N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
- Papaya Research and Applications
- Cholinesterase and Neurodegenerative Diseases
- HIV/AIDS drug development and treatment
- Chemical synthesis and alkaloids
- Click Chemistry and Applications
- Ginkgo biloba and Cashew Applications
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Synthesis and Catalytic Reactions
- Essential Oils and Antimicrobial Activity
- Synthetic Organic Chemistry Methods
- Pain Management and Opioid Use
- Carbohydrate Chemistry and Synthesis
- Cannabis and Cannabinoid Research
- Anorectal Disease Treatments and Outcomes
University of Pretoria
2012-2024
University of Cape Town
2008-2011
The reactions of potassium salts the dithiocarbamates L {where = pyrazolyldithiocarbamate (L1), 3,5-dimethylpyrazolyldithiocarbamate (L2), or indazolyldithiocarbamate (L3)} with gold precursors [AuCl(PPh3)], [Au2Cl2(dppe)], [Au2Cl2(dppp)], [Au2Cl2(dpph)] lead to new gold(I) complexes [AuL(PPh3)] (1-3), [Au2L2(dppe)] (4-6), [(Au2L2)(dppp)] (7-9), and [Au2(L)2(dpph)] (10-12) dppe 1,2-bis(diphenylphosphino)ethane, dppp 1,3-bis(diphenylphosphino)propane, dpph 1,6-bis(diphenylphosphino)hexane}....
Tea (Camellia sinensis) has been consumed for centuries as traditional medicine various diseases, including diabetes. The mechanism of action many medicines, tea, often requires elucidation. Purple tea is a natural mutant Camellia sinensis, grown in China and Kenya, rich anthocyanins ellagitannins. Here we aimed to determine whether commercial green purple teas are source ellagitannins teas, their metabolites urolithins have antidiabetic activity. Targeted UPLC-MS/MS was employed quantify...
The N-heterocyclic carbene (NHC) precursors 1-[(E)-2-butenyl]-3-(4-ferrocenylphenyl)imidazolium bromide (2) and tetrafluoroborate (3) were derived from 1-(4-ferrocenylphenyl)imidazole. Ferrocenyl complex 3 reacts with Ag2O chloro(dimethylsulfide)gold(I) in the presence of tetraethylammonium chloride to produce mixed metal species bis{1-[(E)-2-butenyl]-3-(4-ferrocenylphenyl)-2H-imidazol-2-ylidene}gold(I) (4). Single crystal X-ray structure analyses 1, 4 indicate that NCHN-hydrogen is hydrogen...
Ylideneamine functionalised heterocyclic ligands, 1,3-dimethyl-1,3-dihydro-benzimidazol-2-ylideneamine (I), 3-methyl-3H-benzothiazol-2-ylideneamine (II) or 3,4-dimethyl-3H-thiazol-2-ylideneamine (III), were employed in the preparation of a series both charged and neutral gold(I) complexes consisting either Au(C6F5) fragment (1–3), [Au(PPh3)]+ unit (4–6) [Au(NHC)]+ (7) coordinated to imine nitrogen ylideneamine ligand. These fully characterised by various techniques including X-ray...
This study investigated a unique one-pot microwave-assisted green synthesis method of gold (Au) and silver (Ag) nanoparticles (NPs) using cannabidiol (CBD) as capping reducing agent. Furthermore, Au Ag NPs were also chemically synthesized poly(vinyl pyrrolidone), which functioned reference materials when comparing the size, shape, cytotoxicity NPs. Synthesis parameters such reaction time, temperature, precursor molar ratio optimized to control size shape biosynthesized Various...
Parkinson's disease, characterised by loss of dopaminergic neurons in the substantia nigra brain, is attributed to oxidative stress and mitochondrial dysfunction. As no cure available, dopamine-replacement therapy only offers symptomatic relief, other avenues treatment are sought. Acokanthera oppositifolia, Boophone disticha Xysmalobium undulatum used ethnomedicinally for neurological disorders, however, these plants have not been assessed vitro cytoprotective activity. The aim study was...
Oxidation of the pyrazol-1-yldithiocarbamate compounds {[3,5-R 2 C 3 HN CS ] - (R = H, Me} and indazol-1-lydithiocarbamate by iodine produces sulfur-sulfur coupling {R'C(S)S-S(S)CR'} (R’ pyrazolyl, 3,5-dimethylpyrazolyl, indazolyl). All were spectroscopically characterised, and, in some cases, structurally characterised. The X-ray structures reveal that these contain a disulfide bridging pyrazolylthiocarbonyl units. Two three showed very good anticancer activities against HeLa cells at...
The design of hybrid compounds is a distinct approach for developing potent bioactive agents. Carvacrol, an essential oil, exhibits antimicrobial, antifungal, antioxidant, and anticancer activity, making it good precursor the development with biological activities. Some patents have reported carvacrol derivatives promising activities.This study aimed to prepare containing scaffold significant antibacterial activity.Esterification reactions between known pharmacophores were performed at room...
A range of unique Rh-based bidentate NHC complexes that are formed in a base-free tandem isomerization/cyclometalation process were synthesized (1–4) from imidazolium salts with an N-alkenyl tether. Cyclometalation occurred complex 1, leading to unprecedented complex, which is the first and only example literature nonaromatic C(sp2)–H activation C(sp3)–Rh cyclometalated product concomitant intramolecular/isomerization process. Dealkylation substituent form byproducts showed metal...
Abstract This research paper explores the field of nanobiotechnology, focusing on design, characterisation, and potential dermal applications metal oxide nanoparticles (MONPs). ZnO FeO NPs exhibit distinctive properties that are valuable in dermato‐cosmetic transdermal drug delivery. study investigates Cannabidiol (CBD) as a capping agent for MONPs synthesis. Employing microwave‐assisted techniques, were synthesised using either CBD or polyvinylpyrrolidone (PVP) agents. The TEM, SEM, FTIR,...
β-Secretase (BACE1) is recognised as a target for the treatment of Alzheimer's disease, and transition-state isosteres such hydroxyethylamines have shown promise when incorporated into BACE1 inhibitors.A computational investigation previously reported carbazole-based hydroxylethylamines with contradictory binding poses was undertaken using molecular dynamic simulations to rationalise ligands preferred preference.Visual inspection confirmed pocket showed unoccupied space surrounding carbazole...
Background: Successful treatment of moderate to severe acute pain often necessitates several analgesics that target different sites the nociceptive pathway. Fixed-dose combination facilitate a reduction in dose individual components, increased compliance and strong-opioid sparing. The aim this study was compare analgesic anxiolytic efficacy tolerability two widely prescribed analgesics, Stilpane® (paracetamol/codeine/meprobamate) Tramacet® (paracetamol/tramadol). Methods: A prospective...
Introduction: Teicoplanin is an effective treatment option against methicillin-resistant, Gram-positive bacteria, like Staphylococcus aureus. It a glycopeptide antibiotic, produced through microbial fermentation, process resulting in variations the N-acyl side chain. Concerns that these may affect pharmacokinetic profile and clinical efficacy of generic teicoplanin preparations have been raised.Method: To address this issue, multi-centre observational study was conducted to evaluate...