A5016599557- Chemical synthesis and alkaloids
- Ethnobotanical and Medicinal Plants Studies
- Medicinal Plants and Neuroprotection
- Alkaloids: synthesis and pharmacology
- Cholinesterase and Neurodegenerative Diseases
- Essential Oils and Antimicrobial Activity
- Complementary and Alternative Medicine Studies
- Phytochemistry and Biological Activities
- Natural product bioactivities and synthesis
- Plant Diversity and Evolution
- Phytochemicals and Antioxidant Activities
- Pharmacological Effects of Medicinal Plants
- Phytochemistry and Bioactive Compounds
- African Botany and Ecology Studies
- Food Science and Nutritional Studies
- Seed and Plant Biochemistry
- Neuroscience and Neuropharmacology Research
- Psychedelics and Drug Studies
- Biochemical Analysis and Sensing Techniques
- Pharmacological Effects of Natural Compounds
- Phytochemical and Pharmacological Studies
- Piperaceae Chemical and Biological Studies
- Plant chemical constituents analysis
- Biological Activity of Diterpenoids and Biflavonoids
- Botanical Research and Applications
University of Pretoria
2018-2024
Stellenbosch University
2016-2018
University of Zurich
2017
University of Copenhagen
2010-2016
Natural History Museum Aarhus
2011-2016
University of KwaZulu-Natal
2004-2013
Natural History Museum of Denmark
2011-2012
During evolution, plants and other organisms have developed a diversity of chemical defences, leading to the evolution various groups specialized metabolites selected for their endogenous biological function. A correlation between phylogeny biosynthetic pathways could offer predictive approach enabling more efficient selection development traditional medicine lead discovery. However, this relationship has rarely been rigorously tested potential power is consequently unknown. We produced...
The review focuses on acetylcholinesterase (AChE) inhibition of extracts and compounds from southern African plants. We provide a detailed inventory plants used in the treatment central nervous system (CNS) memory-related disorders that are potential candidates for novel AChE inhibitors. This was achieved through literature search using web-based database searches including Google Scholar, Scopus Web Science (WoS) as well ethnobotanical medicinal Bibliometric analysis performed data mined...
The genus Podocarpus sensu latissimo (s.l.) was initially subdivided into eight sections. However, based on new information from different morphological and anatomical studies, these sections were recognised as genera. This change in nomenclature sometimes is problematic when consulting ethnobotanical data especially selecting plants for pharmacological screening, thus there a need to clear any ambiguity with the nomenclature. Species of s.l. are important timber trees their native areas....
The modern trend in traditional medicines reflects an increase the sale of complex herbal mixtures rather than those prepared from single plants. This is well documented Traditional Chinese Medicine (TCM) and can be seen recent developments African medicine. An prevalence locally produced preparations, especially containing several medicinal plants, sold numerous retail outlets, including supermarkets pharmacies has been observed. appearance these preparations not surprising rapidly...
Traditional health care is utilized by a large majority of the population in southern Africa. This particularly true treatment for mental problems. A part regimes used traditional healers involve numerous herbal preparations. Twenty plants traditionally were screened MAO inhibition and specific MAO-B activity. inhibitors are currently employed neurodegenerative related illnesses such as Parkinson's Alzheimer's disease. photometric peroxidase linked assay was to determine oxidative...
This study investigated the potential health‐promoting properties of new sources natural food colorants, namely pigmented flower extracts from Geraniaceae ( Pelargonium grandiflorum, × hortorum, zonale hybrid) and Lamiaceae Salvia aurea dolomitica, dolomitica Plectranthus zuluensis ). In family, main phenolic acids identified were hydrolysable tannins, while flavonoids rutinosides kaempferol quercetin. caffeic acid its derivatives, naringin neohesperidin. The total polyphenol content (TPC)...
Boophone disticha L. Herb (Amaryllidaceae) is used in traditional medicine for treatment of painful wounds, headaches, skin disorders, inflammatory conditions, rheumatic pains and anxiety. At least eight alkaloids have been characterized reported the literature. Of these buphanidrine buphanamine affinity to serotonin transporter (SERT). Alkaloids from other Amaryllidaceae species also shown SERT. In this study, an ethanol extract was prepared dry bulbs. Through HPLC–UV separation five peaks...
Piper capense L.f. (Piperaceae) is used traditionally in South Africa as a sleep inducing remedy. Bioassay-guided fractionation of the roots P. led to isolation piperine (1) and 4,5-dihydropiperine (2), which showed moderate affinity for benzodiazepine site on GABA(A) receptor (IC(50) values 1.2 mM 1.0 mM, respectively). The present study suggests that strict structural properties amides are essential affinity. Taken together, these observations suggest carbon chain must contain not less...
We present phylogenetic analyses of 37 taxa Amaryllidaceae, tribe Haemantheae and Amaryllis belladonna L. as an outgroup, in order to provide a framework for the selection candidate plants lead discoveries relation Alzheimer's disease depression. DNA sequences from nuclear ribosomal internal transcribed spacer (ITS) plastid trnL-F regions were used. Maximum parsimony increased support sister relationship Haemanthus Scadoxus. Within Haemanthus, well supported clade (89% BS) corresponds summer...