A5070918468- Synthesis and Characterization of Heterocyclic Compounds
- Chemical Reaction Mechanisms
- Synthesis and biological activity
- Synthesis of heterocyclic compounds
- Synthesis and Biological Evaluation
- Synthesis and Reactivity of Heterocycles
- Synthesis and Reactions of Organic Compounds
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Phenothiazines and Benzothiazines Synthesis and Activities
- Multicomponent Synthesis of Heterocycles
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Synthesis of Organic Compounds
- Cancer therapeutics and mechanisms
- Bioactive Compounds and Antitumor Agents
- Chemical Synthesis and Analysis
- Enzyme Catalysis and Immobilization
- Electrochemical Analysis and Applications
- Quinazolinone synthesis and applications
- Cyclopropane Reaction Mechanisms
- DNA and Nucleic Acid Chemistry
- Inorganic and Organometallic Chemistry
- Neuroscience and Neuropharmacology Research
- Crystallography and molecular interactions
- Analytical Chemistry and Chromatography
Latvijas Organiskās Sintēzes Institūts
2014-2023
Institute of Organic Synthesis
2007-2022
Institute of Molecular Biology and Pathology
2018
Universidade Nova de Lisboa
2018
Google (United States)
2018
Tulane University
2018
Instituto de Biologia Experimental e Tecnológica
2018
Sapienza University of Rome
2018
Latvian Academy of Sciences
1986-2010
Slovak Academy of Sciences
2009
This review surveys the l a t e s developments pertaining o preparation of 1.4-dihydropyridines using Hantzsch synthesis and other cyclocondensation reactions.The chemistry f dihydropyridines (DHP) up year 1980 had been reviewed i n several literature1-3.Among different isomers, 1.4-DHP merits special attention, r these compounds increasing progressively.Investigations along include model NAD(P)H-analogues 1.4-dihydronicotinamideand h involvement hydrogen transfer reactions.Recently, papers...
Recent studies o f chemical r e a c t i v y of 1.4-dihydropyridines surveyed 1The chemistry dihydropyridines (DHP) up the year 1980 was treated n d l .Recently acquired data g synthesis condensation reactions have been sumnarized too2.The present review analyses 1,4-dihydropyridines cover-
Oxidative stress has been implicated in pathophysiology of different human stress- and age-associated disorders, including osteoporosis for which antioxidants could be considered as therapeutic remedies was suggested recently. The 1,4-dihydropyridine (DHP) derivatives are known their pleiotropic activity, with some also acting antioxidants. To find compounds potential antioxidative a group 27 structurally diverse DHPs, well one pyridine compound, were studied. A 11 DHPs 10-fold higher than...
Abstract Diabetes mellitus (DM) is an important cardiovascular risk factor and associated with abnormalities in endothelial vascular smooth muscle cell function, evoked by chronic hyperglycemia hyperlipidemia. Chronic insulin deficiency or resistance marked decreases the intensity of glucose transport, phosphorylation, oxidation, plus ATP levels cardiac myocytes. It to search for new agents that promote consumption heart partially inhibit extensive fatty acid beta‐oxidation observed...
Abstract The synthesis of cationic amphiphilic 1,4-dihydropyridine derivative, potential gene delivery agent is achieved via an efficient multi-step sequence. key step this approach a two-component Hantzsch type cyclisation 3-oxo-2-[1-phenylmethylidene]-butyric acid dodecyl ester and 3-amino-but-2-enoic utilising bis(2-hydroxyethyl)ether as solvent 1-butyl-4-methylpyridinium chloride catalyst. derivative with long alkyl chains at positions 3 5 the 1,4-DHP ring —...
Seventeen 1,4-dihydropyridine (1,4-DHP) amphiphiles including differently substituted pyridinium, pyrazinium, N-methyl piperidinium or morpholinium moieties as the cationic head-group of molecule have been designed and synthesised. 1,4-DHP earlier proposed a promising tool for plasmid DNA (pDNA) delivery in vitro. In this work ability to self-assemble, bind pDNA transfer it into cells well cytotoxicity amphiphiles–pDNA complexes was studied. Furthermore, antiradical activity (ARA)...
The diastereotopy of the methylene protons at positions 2 and 6 in 1,4-dihydropiridine derivatives with various substituents has been investigated. NMR spectroscopy quantum chemistry calculations show that CH···O intramolecular hydrogen bond is one factors amplifying chemical shift differences 1H-NMR spectra.
Since 2,6-dimethyl-4-aryl-1,4-dihydropyridine 3,5-diesters themselves are not hydrolyzed by commercially available hydrolases, derivatives with spacers containing a hydrolyzable group were prepared. Seven acyloxymethyl esters of 5-methyl- and 5-(2-propoxyethyl) 4-[2-(difluoromethoxy)phenyl]-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylate synthesized subjected to Candida rugosa lipase (CRL) catalyzed hydrolysis in wet diisopropyl ether. A methyl ester at the 5-position long or branched...
Sirtuin 6 (SIRT6), a member of sirtuin family (SIRT1-7), regulates variety cellular processes involved in aging, metabolism, and cancer. Dysregulation SIRT6 is widely observed different breast cancer subtypes; however, the role function development remain largely unexplored. The aim this study was to identify novel compounds targeting which may provide new approach anti-cancer therapy for Virtual screening utilized discover potential vitro screening. In addition, 1,4-dihydropyridine...
Endopolyploidy and genomic instability are shared features of both stress-induced cellular senescence malignant growth. Here, we examined these facets in the widely used normal human fibroblast model senescence, IMR90. At presenescence stage, a small (2–7%) proportion cells overcome 4n-G1 checkpoint, simultaneously inducing self-renewal (NANOG-positivity), DNA damage response (DDR; γ-H2AX-positive foci), (p16inka4a- p21CIP1-positivity) signalling, some reach octoploid content divide. All...