A5054110445- Retinal Diseases and Treatments
- Retinal and Optic Conditions
- Retinal Imaging and Analysis
- Retinal Development and Disorders
- Ocular Diseases and Behçet’s Syndrome
- Biomedical Research and Pathophysiology
- Birth, Development, and Health
- Vasculitis and related conditions
- Retinopathy of Prematurity Studies
- Body Image and Dysmorphia Studies
- Female Genital Mutilation/Cutting Issues
- Ocular Oncology and Treatments
University of Lausanne
2022-2025
Fondation Asile des Aveugles
2022-2025
Moorfields Eye Hospital NHS Foundation Trust
2021-2024
Moorfields Eye Hospital
2021-2024
University College London
2021-2024
National Institute for Health Research
2021-2024
Hôpital Ophtalmique Jules-Gonin
2022
National Health Service
2021
Inherited retinal disease (IRD) is a leading cause of blindness. Recent advances in gene-directed therapies highlight the importance understanding genetic basis these disorders. This study details molecular spectrum large UK IRD patient cohort. Retrospective electronic records. Patients with who have attended Genetics Service at Moorfields Eye Hospital between 2003 and July 2020, whom diagnosis has been identified. Genetic testing was undertaken via combination single-gene testing, gene...
Quantitative volumetric measures of retinal disease in optical coherence tomography (OCT) scans are infeasible to perform owing the time required for manual grading. Expert-level deep learning systems automatic OCT segmentation have recently been developed. However, potential clinical applicability these is largely unknown.To evaluate a model whole-volume 4 clinically important pathological features and assess applicability.This diagnostic study used data from 173 patients with total 15 558...
Abstract Background This study was conducted as a retrospective, exploratory analysis to assess early anatomical and functional effects of intravitreal aflibercept 8 mg in neovascular age-related macular degeneration (nAMD) small cohort patients. Methods retrospective at the Jules Gonin Eye Hospital Lausanne, Switzerland, included treatment-naïve patients with nAMD. Patients received minimum two injections (IVT) over 3-month period. Key outcomes assessed were changes best-corrected visual...
We sought to explore whether sex imbalances are discernible in several autosomally inherited macular dystrophies.
Biallelic pathogenic variants in ABCA4 are the commonest cause of monogenic retinal disease. The full-field electroretinogram (ERG) quantifies severity dysfunction. We explored application machine learning ERG interpretation and genotype-phenotype correlations.International standard ERGs 597 cases retinopathy were classified into three functional phenotypes by human experts: macular dysfunction alone (group 1), or with additional generalized cone 2), both rod 3). Algorithms developed for...
To describe the clinical outcomes following implementation of a high-volume medical retina virtual clinic utilising diagnostic hub.Retrospective consecutive case-series all patients attending clinics at Moorfields Eye Hospital (City Road) for 6 weeks from September 21, 2020.In weeks, 1006 attended clinics, which included an appointment in hub followed by assessment asynchronously working day. The vast majority were follow-up attendances (969, 96.3%) with much fewer new patient (37, 3.7%)....
Abstract Pathogenic variants in the genes encoding serine palmitoyl transferase ( SPTLC1 or SPTLC2 ) are most common causes of rare peripheral nerve disorder Hereditary Sensory Neuropathy Type 1 (HSN1). Macular telangiectasia type 2 (MacTel), a retinal associated with disordered serine‐glycine metabolism, has been described some patients HSN1. This study aims to further investigate this association cohort people Fourteen clinically and genetically confirmed diagnosis HSN1 from National...
Het hymen, ook wel „maagdenvlies” genoemd, kan geschonden worden tijdens de eerste seksuele betrekkingen, maar op velerlei andere, niet-seksueelgerelateerde wijzen. In culturen waar veel waarde gehecht wordt aan vrouwelijke maagdelijkheid, voorhuwelijkse ontmaagding een bron van schaamte en schending eer betekenen voor betrokkene haar familie. Deze vrouwen, met inbegrip bruiden wie maagdelijkheid niet bewezen bij huwelijksnacht, lopen hierdoor het risico onder meer publieke vernedering,...
To assess the clinical efficacy of fluocinolone acetonide (FA) intravitreal implant (Iluvien, Alimera Sciences) over a 12-month period in population resistant to treatment with first-line anti-VEGF agents.This study is retrospective cohort assessing functional and anatomical outcomes 13 eyes 12 patients treated for diabetic macular oedema (DMO) single (Iluvien) under real-world conditions. The follow-up includes time first (incl or short-lasting steroids) given until months post FA...
In previous landmark studies on central retinal vein occlusion, nonperfusion assessments were obtained using 7-field (7F) angiography. The widespread current use of widefield imaging allows better visualization the peripheral retina and more comprehensive estimation total area nonperfusion. relationship between measurement 7F angiography (WFA) in occlusion has not been studied. We aim to identify correlation measured within WFA eyes with occlusion.Retinal participants was determined a Early...