Abstract Background: Early identification of high-risk patients presenting with ST-segment elevation myocardial infarction (STEMI) helps prevent complications. The shock index (SI) is a bedside risk-stratification tool used in emergency departments. In this study, we aimed to assess the SI’s predictive value for prognosticating in-hospital and one-year mortality, as well major cardiovascular events (MACEs). As secondary endpoints, assessed age performance influence prehospital transport...

Background: The present research is a case-control study to analyze the influence of pre-miRNA-146a rs2910164 and pre-miRNA-499 rs3746444 polymorphisms as candidate susceptibility factors for both rheumatoid arthritis (RA) systemic lupus erythematosus (SLE). Methods: Polymorphism in miR146 miR499 using ARMS-PCR was genotyped on 139 autoimmune disease (AD) patients (89 RA 50 SLE) referred Educational Hospitals Khorramabad, Lorestan Province, west Iran 2018–2019 237 healthy control subjects....

To investigate the association between polymorphism of miR-146a and The ubiquitin-like with PHD ring-finger domains 1 (UHRF1) expression in patients gastric cancer.MiR-146a rs2910164 was genotyped 130 cancer cancer-free individuals using polymerase chain reaction (PCR)-restriction fragment length polymorphism. UHRF1 analyzed 22 tissues their adjacent normal quantitative real-time PCR.No significant differences genotype distributions were found cases controls, but we observed that grade II...

A growing body of literature has revealed the effective role miR-34a, as a tumor suppressor and regulator expression multiple targets in tumorigenesis cancer progression. This study aimed at evaluating potential effects miR-34a alone or combination with paclitaxel on breast cells.After transduction by lentiviral vectors two MCF-7 MDA-MB-231 cell lines cancer, elevated viability proliferation were determined using MTT assay treated untreated cells paclitaxel. The mRNA level CCND1 (Cyclin...

Experimental myocardial infarction triggers secretion of Stromal cell-derived factor1 and lead to increase in the expression its receptor "CXCR4" on surface various cells. The aim this study was evaluate pattern CXCR4 peripheral blood cells following time-course permanent temporary ischemia rats.Fourteen male Wistar rats were divided into two groups seven placed under transient ischemia. Peripheral mononuclear isolated at different time points, RNAs extracted applied qRT-PCR analysis...

Heart failure (HF) is considered the leading cause of cardiac-related morbidity and mortality during pregnancy. Peripartum cardiomyopathy (PPCM) presents diagnostic challenges, often mirroring dilated (DCM). The aim study to evaluate echocardiographic features, including global segmental longitudinal strain values, in pregnant women with a history newly diagnosed left ventricular systolic dysfunction (LVSD) third trimester

Vesicoureteral reflux (VUR) disease is the most common type of urinary tract anomalies in children. Genetic risk factors may be associated with etiology VUR. The role Glutathione S-transferases (GSTs) as multifunctional enzymes cellular oxidative stress handling. This first study aimed at evaluating relative GSTP1, GSTM1, and GSTT1 polymorphisms VUR susceptibility children provides new important insights into genetics affected children.The was done 2013 Sistan Baluchestan University, eastern...

Background: Mortality of ST-elevation myocardial infarction (STEMI) patients is increasing in world. This study defines predictors mortality who have STEMI. Materials and Methods: was a part the ST-elevated cohort Isfahan conducted on 876 acute (MI) followed for 2 years that 781 patient entered. The effect includes demographic, physiological, clinical characterizes compared two groups alive died patients. MACE defined as nonfatal MI, stroke, atherosclerosis cardiovascular disease-related...

Abstract Background: Survivors of acute myocardial infarction(AMI) struggle with stressful consequences. Sense coherence(SOC) seems to be associated a person's capacity face life incidents. The current study aims evaluate SOC's correlation the major adverse cardiac events(MACE) among AMI survivors. was designed and reported following STROBE guidelines checklist. Methods: This part ST-elevated infarction cohort in Isfahan(SEMI-CI) conducted on 724 survivors followed for two years. patients'...

Ventricular septal rupture (VSR) is an ominous mechanical complication of acute myocardial infarction (MI) accompanied with a poor prognosis. Transcatheter closure (TCC) VSR has been proposed as alternative approach for surgery. This study presents 79-year-old man diabetes mellitus, hypertension, dyslipidemia, and chronic stable angina 3-vessel coronary artery disease, who had refused bypass graft. He complained orthopnea dyspnea New York Heart Association (NYHA) function class III after the...

Stroke is one of the primary causes morbidity and mortality worldwide, including a large proportion cryptogenic strokes. Long-term electrocardiographic monitoring beneficial in prospective studies for detecting atrial fibrillation patients with stroke. This review aimed to evaluate advanced echocardiographic parameters their roles assessing left (LA) function incidence ischemic Main resources, PubMed, Scopus, ISI Web Science databases, were evaluated articles published English from 2010...