A5016078623- Blood Coagulation and Thrombosis Mechanisms
- Platelet Disorders and Treatments
- Venous Thromboembolism Diagnosis and Management
- Hemophilia Treatment and Research
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Blood properties and coagulation
- Trauma and Emergency Care Studies
- Heparin-Induced Thrombocytopenia and Thrombosis
- Cardiovascular Issues in Pregnancy
- Blood groups and transfusion
- Antiplatelet Therapy and Cardiovascular Diseases
- Hemostasis and retained surgical items
- Intramuscular injections and effects
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Blood disorders and treatments
- Healthcare Systems and Practices
- Renal Diseases and Glomerulopathies
- Cardiac Arrest and Resuscitation
- Atrial Fibrillation Management and Outcomes
- Vitamin K Research Studies
- Acute Myocardial Infarction Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Blood transfusion and management
- Uterine Myomas and Treatments
- Diagnosis and Treatment of Venous Diseases
Hospices Civils de Lyon
2015-2024
Lille’s Cardiology Hospital
1999-2024
Hôpital Louis Pradel
2015-2023
Université Claude Bernard Lyon 1
2008-2022
Hôpital Femme Mère Enfant
2021-2022
B2 (Slovenia)
2016
Hôpital Albert Michallon
2016
Mayo Clinic in Arizona
2016
Hôpital Edouard Herriot
2005-2015
Clinique Ambroise Paré
2015
Summary Patients with thrombophilia and/or a history of venous thromboembolism (VTE) exhibit high risk thrombosis during pregnancy. The present multicentre study prospectively assessed prophylaxis strategy, based on score, in pregnancies increased VTE. Among 286 patients included the study, 183 had personal VTE (63·98%) and 191 (66·8%) marker. Eighty nine (46·6%) thrombophilic women were assigned to one three strategies according scoring system. In postpartum, all received low molecular...
Factor XI (FXI) deficiency is a rare bleeding disorder. Most patients with FXI are mild bleeders but certain similar activity exhibit different phenotype. Routine laboratory assays do not help physicians to estimate the individual risk in these patients. Thrombin generation test (TGT) more comprehensive, global function of clotting system. We investigated whether or tendency correlated features TGT. Twenty-four were divided two groups: (i) severe (n = 9) and (ii) non-bleeders 15). All had...
In pregnant women with antecedents of autoimmune thrombocytopenia (AITP), no predictive factor for severe fetal has been identified. We evaluated the relationships between course maternal disease before and during pregnancy risk thrombocytopenia, in 64 known chronic AITP antecedents, over a 12‐year period. 28 had undergone splenectomy 17 experienced (< 50 × 10 9 /l) (monthly determination). Eight infants presented at birth (12.5%), four following days (6.25%). No haemorrhage was observed....
Summary. The pathophysiology of acquired von Willebrand syndrome (AVWS), a rare bleeding disorder, is not fully understood. Circulating antibodies to Von factor (VWF) are found in patients with AVWS associated lymphoproliferative disorders but these autoantibodies difficult detect routine laboratory tests and neutralisation assays. We have developed simple enzyme‐linked immunosorbent assay (ELISA) serum antibody binding VWF protein immobilized on polystyrene plates. Ten were studied, eight...
Background and Objectives on Willebrand's disease (VWD) is the most common hereditary bleeding disorder. Its severity can be classified basis of von Willebrand factor (VWF) VIII (FVIII) plasma levels according to clinical relevance episodes. However, patients with very low VWF activity may exhibit a mild tendency. The for this heterogeneous expression deficit still poorly understood. We investigated relationship between thrombin generation VIII, tendency.Design Methods Thrombin was measured...
Antithrombin (AT) is a major physiological inhibitor of hemostasis. We report 22 novel antithrombin gene (SERPINC1) mutations associated with deficiency in 17 French and five German families. They were all present at the heterozygous state. Nine missense accounted for type I deficiency, defined by equally low activity antigen level. Most them (7/9) affected highly conserved serpin residues venous thrombosis occurring young age (before 32). One splice site, one nonsense mutation, three small...
Thromboelastometry (ROTEM, Pentapharm GmbH, Munich, Germany) is increasingly being used to make a diagnosis of coagulopathy and guide hemostatic therapy (HT). Although ROTEM parameters standard laboratory test (SLT) correlated well before administration HT, it not known if this correlation persists after resuscitation.A retrospective analysis prospectively collected data from trauma registry (2011-2014) was performed. All patients having were included. (clotting time clot amplitude at 5...
BACKGROUND: Rapid and accurate determination of prothrombin time in trauma patients may help to faster control bleeding induced coagulopathy. The goal this prospective observational study was investigate the accuracy bedside measurements by mean a point-of-care device (INRatio) patients. METHODS: Fifty blood samples were drawn at admission during acute care phase for standard coagulation assays (prothrombin time, International Normalized Ratio [INR], fibrinogen) INRatio testing (INRA) from...
Abnormal plasma concentrations of von Willebrand factor (vWF), a marker prothrombotic risk, have been found in atrial fibrillation (AF) patients, but the extent this variation is not clear. This study aimed to investigate effect different clinical forms AF on vWF at levels circulatory tree, both intracardiac and extracardiac.Peripheral (Pf), left (LA), coronary sinus (CS) blood samples were obtained during cardiac catheterization from 52 patients with paroxysmal (PAF), 36 persistent (PsAF),...
Introduction:During the treatment of Hemophilia A patients without inhibitors using factor VIII (FVIII) activity-mimicking bispecific antibody Emicizumab (Hemlibra) bleeding episodes can occur, which require administration FVIII concentrates to restore hemostasis.Because Emicizumab's specificity for human coagulation factors, levels in presence be measured by a chromogenic activity assay based on bovine reagents.However, novel agents could lack this and thus not allow successfully follow...
Background —Basic fibroblast growth factor (bFGF) promotes vascular repair and angiogenesis can induce in vitro tissue (TF), a potent agent initiating thrombogenesis, which probably plays role angiogenesis. We investigated whether bFGF administration induced TF expression by monocytes cells. Methods Results —We studied normally fed (n=16) cholesterol-fed (2% for 6 weeks, n=16) rabbits. Animals were then randomized to receive intravenous (2.5 μg twice weekly 3 weeks) or saline injections. was...
Summary Introduction Recently, rapid immunoassays have been developed to allow the detection of antibodies anti‐ PF 4/heparin. In this prospective study, we evaluated performances a automatized immunoassay (Hemos IL HIT ‐Ab) in comparison with an ELISA (Zymutest HIA IgG) used for diagnosis heparin‐induced thrombocytopenia ( ) association 4T's score. Methods According score, samples score ≤3 had no further analysis. Two immunological assays Zymutest IgG and Hemos ‐Ab were performed ≥4....