A5059462837- Epilepsy research and treatment
- Genetic diversity and population structure
- Amino Acid Enzymes and Metabolism
- Identification and Quantification in Food
- Neuroscience and Neuropharmacology Research
- Nanoplatforms for cancer theranostics
- Genetic and phenotypic traits in livestock
- Peptidase Inhibition and Analysis
- Molecular Biology Techniques and Applications
- Antenna Design and Optimization
- Ion channel regulation and function
- Hand Gesture Recognition Systems
- Plant and animal studies
- Environmental DNA in Biodiversity Studies
- Radiopharmaceutical Chemistry and Applications
- Enzyme Structure and Function
- Cancer Research and Treatments
- Bird parasitology and diseases
- Metabolism and Genetic Disorders
- Plant and fungal interactions
- Advanced Antenna and Metasurface Technologies
- Microbial Metabolic Engineering and Bioproduction
- Coccidia and coccidiosis research
- Antenna Design and Analysis
- Enzyme Catalysis and Immobilization
University of Freiburg
2023
Leibniz-Institute for New Materials
2023
Colorado College
2023
University of New Haven
2021
University of Oslo
2021
Yale University
2019-2020
Florida International University
2016-2019
To test the hypothesis that glutamate and GABA are linked to formation of epilepsy networks triggering spontaneous seizures, we examined seizure initiation/propagation characteristics neurotransmitter levels during epileptogenesis in a translationally relevant rodent model mesial temporal lobe epilepsy.The glutamine synthetase (GS) inhibitor methionine sulfoximine was infused into one hippocampi laboratory rats create focus. Long-term video-intracranial EEG recordings brain microdialysis...
Background: Glutamine synthetase (GS) is the only enzyme known to synthesize significant amounts of glutamine in mammals, and loss GS hippocampus has been implicated pathophysiology medication refractory mesial temporal lobe epilepsy (MTLE). Moreover, loss-of-function mutations gene causes severe epileptic encephalopathy, supplementation with shown normalize EEG possibly improve outcome these patients. Here we examined whether oral an effective treatment for MTLE by assessing frequency...
Abstract Topoisomerase inhibitors are potent DNA damaging agents with great potential as anti-cancer drugs for a wide range of solid tumors. However, dose-limiting toxicities such myelosuppression and gastric toxicity have prevented them from reaching their full clinical potential. Targeting topoisomerase antibodies (i.e. antibody-drug conjugates; ADCs) may enhance the therapeutic window these agents, but this approach typically limits applicability to small subset patients tumors expressing...
Feral horses roaming North America are distinct not only because of their acclimatization to the wild but also diversified ancestry. The inhabiting Ochoco National Forest near Prineville, Oregon, one remaining mustang herds and protected by Wild Horse Burro Acts 1971 1978. With deterioration rangeland, drought, vegetation conditions, human encroachment, fencing off grazing lands, competition with wildlife, other livestock on public a critical balance between conserving natural ecology...
Communication is the process of exchanging information, views and expressions between two or more person. The types communication are verbal nonverbal. Hand gestures nonverbal method communication. A organized form hand known as sign. physically disabled person uses these to communicate with everyone. To design a system that can recognize sign language accurately so impaired have normal people main aim for this paper. System follows general steps like capturing image from webcam, compare...
Abstract Cofactor regeneration systems are of major importance for the applicability oxidoreductases in biocatalysis. Previously, geranylgeranyl reductases have been investigated enzymatic reduction isolated C=C bonds. However, an cofactor‐regeneration system vitro use is lacking. In this work, we report a ferredoxin from archaea Archaeoglobus fulgidus that regenerates flavin corresponding reductase. The proteins were heterologously produced, and was coupled to reductase Escherichia coli...
Abstract Maytansines and their derived maytansinoid DMx compounds are high potency microtubule targeting that have an extremely narrow therapeutic window. Unacceptable dose limiting systemic toxicity has limited the potential of these potent anti-oncogenic compounds. Targeting maytansinoids to tumor is only feasible method unlocking clinical such toxic molecules. To date Trastuzumab-DM1 (Kadcyla®) remains approved antibody-maytansinoid conjugate on market. Most preclinical conjugates face...
The plan of microstrip Antenna with conservative size is recommended for remote correspondence. the recieving wire a minimized variety customary radio wire. electromagnetically coupled feed from lower layer utilized to energize proposed full recurrence than that same actual size. addition can be expanded by utilizing parasitic component over fundamental radiator and fixed spacer ideal level. reenactment investigation different boundaries planned finished in Advance Design System...