A5069251395- Viral Infectious Diseases and Gene Expression in Insects
- Bone Tissue Engineering Materials
- Orthopaedic implants and arthroplasty
- Insect Resistance and Genetics
- Virus-based gene therapy research
- Dental Implant Techniques and Outcomes
- CAR-T cell therapy research
- Plant Virus Research Studies
- Bone fractures and treatments
National Yang Ming Chiao Tung University
2010-2011
Institute of Molecular Biology, Academia Sinica
2009
In recent years, baculovirus has emerged as a tool for high-efficiency gene transfer into mammalian cells. However, the level of expression is often limited by strength promoter used. Here, we show that RING protein IE2 strong, promiscuous trans-activator in cells, dramatically upregulating cytomegalovirus (CMV) both Vero E6 and U-2OS Further study cellular mechanism activation led to discovery novel nuclear body structure which contains high concentration G-actin closely associates with RNA...
Sufficient early implant stability is critical to prevent excessive micromovement of the during peri-implant healing and ensure success osseointegration. Implants placed in osteoporotic bones are often associated with low stability. The purpose this study determine effects intramarrow bone morphogenetic protein 4 (BMP4) gene delivery on healing.Adenoviruses encoding human BMP4 or LacZ were introduced into femoral osteotomy sites immediately before placement ovariectomized rabbits. was...
Background: Poor bone quality at implant recipient site is a major risk factor for failure. The purpose of this study to examine the potential intramarrow morphogenetic protein 4 (BMP4) gene delivery local improvement. Methods: Adenoviral vector encoding human BMP4 (Ad‐BMP4) was constructed. Adenovirus β‐galactosidase (Ad‐LacZ) used as control virus. Ad‐BMP4 and Ad‐LacZ were injected into femurs ovariectomized rabbits. temporal changes in mineral density areas determined by repeated...