A5063610407- Photodynamic Therapy Research Studies
- Mitochondrial Function and Pathology
- Endoplasmic Reticulum Stress and Disease
- Adipose Tissue and Metabolism
- Ubiquitin and proteasome pathways
- Crystallization and Solubility Studies
- Animal Genetics and Reproduction
- Autophagy in Disease and Therapy
- Cancer therapeutics and mechanisms
- Nanoplatforms for cancer theranostics
- DNA Repair Mechanisms
- Heat shock proteins research
- X-ray Diffraction in Crystallography
- Reproductive Biology and Fertility
- Crystallography and molecular interactions
- Marriage and Sexual Relationships
- Free Radicals and Antioxidants
- Pluripotent Stem Cells Research
- Cardiovascular Effects of Exercise
- Attachment and Relationship Dynamics
- Synthesis of heterocyclic compounds
- Maternal Mental Health During Pregnancy and Postpartum
- Substance Abuse Treatment and Outcomes
- Renal and related cancers
- Cancer-related molecular mechanisms research
Institute of Biochemistry and Biophysics, Polish Academy of Sciences
2020-2024
University of Tehran
2020-2023
Polish Academy of Sciences
2023
University of Warsaw
2016-2021
Islamic Azad University, Isfahan
2012-2014
Isfahan University of Medical Sciences
2014
Razi University
2011
Photodynamic therapy (PDT) is a clinically approved cancer of low invasiveness. The therapeutic procedure involves administering photosensitizing drug (PS), which then activated with monochromatic light specific wavelength. photochemical reaction produces highly toxic oxygen species. development resistance to PDT in some cells its main limitation. Several mechanisms are known be involved the cellular defense against cytotoxic effects PDT, including activation antioxidant enzymes, efflux...
Photodynamic therapy (PDT) is a valuable treatment method for vulvar intraepithelial neoplasia (VIN). It allows the of multifocal disease with minimal tissue destruction. 5-Aminolevulinic acid (5-ALA) most commonly used prodrug, which converted in heme pathway to protoporphyrin IX (PpIX), an actual photosensitizer (PS). Unfortunately, not all patients treated PDT undergo complete remission. The main cause their failure resistance anticancer therapy. In many cancers, various treatments...
Background: Angiotensin converting enzyme (ACE) is an important gene, which associated with the successful physical activity. The ACE gene has a major polymorphism (I/D) in intron 16 that determines its plasma and tissue levels. In this study, we aimed to determine whether there association between sports performance our studied population including elite athletes of different disciplines. We investigated allele frequency genotype distribution 156 Iranian compared 163 healthy individuals....
Abstract Background Prefoldin is an evolutionarily conserved co-chaperone of the tailless complex polypeptide 1 ring (TRiC)/chaperonin containing (CCT). The prefoldin consists six subunits that are known to transfer newly produced cytoskeletal proteins TRiC/CCT for folding polypeptides. function was recently linked maintenance protein homeostasis, suggesting a more general during cellular stress conditions. acts in adenosine triphosphate (ATP)-independent manner, making it suitable candidate...
Translation is a core process of cellular protein homeostasis and, thus, needs to be tightly regulated. The production newly synthesized proteins adapts the current cell, including response conditions oxidative stress. Overall synthesis decreases upon However, selective initiated help neutralize stress conditions. In contrast higher eukaryotes, fungi require three translation elongation factors, eEF1, eEF2, and eEF3, for synthesis. eEF1 eEF2 are evolutionarily conserved, but they alone...
Abstract The prefoldin complex is a heterohexameric, evolutionarily conserved co-chaperone that assists in the folding of polypeptides downstream protein translation machinery. Loss function leads to impaired solubility cellular proteins. degradation proteins by proteasome an integral part homeostasis. Failure regulated can lead accumulation misfolded and defective We show subunit 5 required for activity contributing assembly 26S proteasome. In particular, we found absence impairs formation...
Abstract Glioblastoma is the most aggressive primary brain tumor. Treatment regimens for glioblastoma tumors, such as surgery, radiotherapy, and chemotherapy, are very invasive can only prolong median patient life to several months. It was shown that 5-aminolevulinic acid (5-ALA)-based photodynamic therapy (PDT) a promising less adjuvant modality diagnosis treatment of glioblastoma. Limiting point PDT outcome appearing cells with intrinsic or acquired resistance finally results in...