A5066538734- Anesthesia and Sedative Agents
- Anesthesia and Pain Management
- Anesthesia and Neurotoxicity Research
- Cardiac, Anesthesia and Surgical Outcomes
- Intensive Care Unit Cognitive Disorders
- Nausea and vomiting management
- Neuroscience and Neuropharmacology Research
- Pain Management and Opioid Use
- Pain Mechanisms and Treatments
- EEG and Brain-Computer Interfaces
- Pain Management and Placebo Effect
- Ion channel regulation and function
- Musculoskeletal pain and rehabilitation
- Enhanced Recovery After Surgery
- Transcranial Magnetic Stimulation Studies
- Pediatric Pain Management Techniques
- Lipid Membrane Structure and Behavior
- Health, Medicine and Society
- Intraoperative Neuromonitoring and Anesthetic Effects
- Neural dynamics and brain function
- Heart Rate Variability and Autonomic Control
- Innovations in Medical Education
- Trigeminal Neuralgia and Treatments
- Hemodynamic Monitoring and Therapy
- Neuroscience and Neural Engineering
University Hospital of Geneva
2013-2024
University of Geneva
2014-2024
Hôpital Beau-Séjour
2011-2024
Charité - Universitätsmedizin Berlin
2004-2017
Geneva College
2017
Praxis
2014
MSB Medical School Berlin
2010
Emory University
2010
Centre Virchow-Villermé
2010
Humboldt State University
2005
Background Approximate entropy, a measure of signal complexity and regularity, quantifies electroencephalogram changes during anesthesia. With increasing doses anesthetics, burst-suppression patterns occur. Because the high-frequency bursts, spectrally based parameters such as median frequency spectral edge 95 do not decrease, incorrectly suggesting lightening The authors investigated whether approximate entropy algorithm correctly classifies occurrence burst suppression deepening Methods...
Although voltage-dependent sodium channels have been proposed as possible molecular sites of anesthetic action, they generally are considered too insensitive to be likely targets. However, most previous studies used peripheral models. To examine the interactions volatile anesthetics with mammalian central nervous system voltage-gated channels, rat brain IIA were expressed in a stably transfected Chinese hamster ovary cell line, and their modification by was examined.Sodium currents measured...
Objectives: Previous studies have indicated that preoperative pain sensitivity correlates with postoperative intensity, and thus may be used to predict severe pain. Self-rating of using the “Pain Sensitivity Questionnaire (PSQ)” an adjunct these measures. Methods: We tested predictive ability PSQ as well experimental parameters other known risk factors for acute in 198 patients scheduled breast cancer surgery. A multivariable logistic regression model was created binary outcome “maximum...
Background Previous studies have provided evidence that clinical levels of propofol alter the functions voltage-dependent sodium channels, thereby inhibiting synaptic release glutamate. However, most these experiments were conducted in presence sodium-channel activators, which channel inactivation. This study electrophysiologically characterized interactions with unmodified channels. Methods Sodium currents measured using whole-cell patch-clamp recordings rat brain IIa channels expressed a...
Summary Movement and haemodynamic responses to noxious stimuli during general anaesthesia are regarded as signs of nociception. We compared the Nociceptive Flexion Reflex Threshold (NFRT), Bispectral Index (BIS), Composite Variability (CVI), Noxious Stimulation Response (NSRI) calculated propofol/remifentanil effect‐compartment concentrations (Ce) predictors for such in 50 female subjects at laryngeal mask airway insertion skin incision. The following prediction probabilities (PK‐values)...
BACKGROUND: The endogenous modulation of pain can be assessed through conditioned (CPM), which quantified using subjective ratings or nociceptive flexion reflexes. However, to date, the test‐retest reliability has only been investigated for ratings. OBJECTIVE: To compare CPM‐induced changes, measured and reflexes, provide a reliable scoring parameter future studies. METHOD: A total 40 healthy volunteers each received painful electrical stimuli sural nerve elicit Reflex sizes were recorded...
<sec> <title>BACKGROUND</title> Chronic pain affects approximately 19% of the European population and poses significant challenges, both in terms individual suffering financial burden on healthcare systems worldwide. While provider expertise is critical, empowering patients with self-management tools has become increasingly important for addressing long-term effectively. </sec> <title>OBJECTIVE</title> This report details development implementation Dolodoc, a mobile application designed by...
We investigate several quantifiers of the electroencephalogram (EEG) signal with respect to their ability indicate depth anesthesia. For 17 patients anesthetized Sevoflurane, three established measures (two spectral and one based on bispectrum), as well a phase space nonlinear correlation index were computed from consecutive EEG epochs. In absence an independent way determine anesthesia depth, standard was derived measured blood plasma concentrations anesthetic via...
Background Anesthesiologists routinely increase the delivered anesthetic concentration before surgical stimulation in anticipation of increased requirement to achieve certain goals (e.g., amnesia, unconsciousness, and immobility). Electroencephalographic monitoring is one method determining indirectly effect on brain. The present study investigated stimuli concentration-response relation desflurane-induced electroencephalographic changes. Methods activity was recorded from 24 female patients...
Background The most common measure to compare potencies of volatile anesthetics is minimum alveolar concentration (MAC), although this value describes only a single point on quantal concentration-response curve and likely reflects more the effects spinal cord rather than brain. To obtain complete curves for cerebral isoflurane, sevoflurane, desflurane, authors used spectral edge frequency at 95th percentile power spectrum (SEF95) as effect. Methods Thirty-nine patients were randomized or...
Immediate postoperative pain could be prevented by the administration of long-lasting analgesics before end anaesthesia. However, to prevent over or underdosing under anaesthesia, tools are required estimate analgesia-nociception balance.We investigated whether pupillary dilation reflex (PDR) and nociceptive flexion (NFR) at general anaesthesia correlate with immediate pain, as a sign analgesic underdosing, delayed tracheal extubation overdosing.Prospective observational study.Klinikum im...
Background The spinal H-reflex has been shown to correlate with surgical immobility, i.e., the absence of motor responses noxious stimulation, during isoflurane anesthesia. Here, authors established individual concentration-response functions for amplitude and tested predictive power movement sevoflurane anesthesia in comparison electroencephalographic parameters. In addition, they investigated effect stimulation on itself. Methods studied 12 female patients before surgery. concentration was...
Background Animal experiments in recent years have shown that attenuation of motor responses by general anesthetics is mediated at least partly spinal mechanisms. Less known about the relative potency anesthetic drugs suppressing cortical and electrophysiological vivo humans, particularly those, but not only connected with responses. Therefore, we studied effects sevoflurane propofol humans using multimodal assessment. Methods We nine healthy volunteers two sessions during steady state...
Abstract Background Pain assessment and proper evaluation of pain are prerequisites for treatment acute chronic pain. Until now, most evaluations have used only resting intensity a unidimensional scale, although multidimensional especially functional impact on activities recommended. The Defense Veterans Rating Scale (DVPRS) permits this assessment, but no validated French translation exists. Objectives To validate the DVPRS, called Functional (FPS), in multiple settings Study design...
The predominant target of anesthetics to suppress movement responses noxious stimuli is located in the spinal cord. Although volatile appear produce immobility by actions on ventral rather than dorsal horn, site action propofol remains unclear.In a crossover design, authors compared 13 volunteers effects sevoflurane and amplitudes H reflex, which mediated exclusively horn withdrawal reflex (RIII Reflex), integrates function. concentrations were adjusted according Dixon up-and-down approach,...
BACKGROUND Intrathecal morphine (ITM) is a widely used technique for postcaesarean section analgesia but entails high risk of postoperative nausea and vomiting (PONV). The transversus abdominis plane (TAP) block an alternative. OBJECTIVE We tested the hypothesis that TAP including clonidine reduces incidence PONV after caesarean when compared with ITM. DESIGN A randomised, controlled, double-blinded study. SETTING Geneva University Hospitals, Switzerland, from October 2013 to February 2017....
Background Molecular theories of general anesthesia often are divided into two categories: (1) Anesthetics may bind specifically to proteins, such as ionic channels, and alter their function directly, (2) anesthetics the functions integral membrane proteins indirectly through modification physical properties membrane. Recent studies have provided evidence that can modify bringing question role in anesthetic interactions. To reexamine lipids interactions, an experimental approach was used...