Endochondral ossification is initiated by the differentiation of mesenchymal precursor cells to chondrocytes (chondrogenesis). This process characterized a strong interdependence cell shape, cytoskeletal organization, and onset chondrogenic gene expression, but molecular mechanisms mediating these interactions are not known. Here we investigated role RhoA/ROCK pathway, well regulator in chondrogenesis. We show that pharmacological inhibition ROCK signaling Y27632 resulted increased...

The molecular mechanisms controlling differentiation of mesenchymal precursor cells into chondrocytes (chondrogenesis) are not completely understood. We have recently shown that the small GTPase RhoA inhibits this process. Here we demonstrate a different Rho family member, Rac1, promotes chondrogenesis. Pharmacological inhibition Rac1 expression in micromass culture resulted reduced mRNA levels chondrogenic markers collagen II and aggrecan, decreased accumulation glycosaminoglycans....

Abstract The intracellular signaling pathways controlling chondrocyte physiology are largely unknown. Here we show that the small GTPases, Rac1 and Cdc42, accelerate rate of differentiation apoptosis, thereby antagonizing activity RhoA. These results identify Cdc42 as novel regulators cartilage development. Introduction: Proliferation, hypertrophic differentiation, ultimate apoptosis chondrocytes regulate endochondral bone growth development, but biology incompletely understood. In this...

The COVID-19 pandemic threatens global food security and has created an urgent need for conservation. This article presents a review of clean plate campaigns around the world. It aims to fight waste reveal factors that may influence waste. Clean Plate Club in US developed during wartime relied heavily on political power compliance, whereas movement South Korea was based religion. China’s Your Campaign (CYPC) gone through two stages: CYPC I II. latter occurred unstable period pandemic....

To investigate the effect of continuous renal replacement therapy (CRRT) in patients with severe acute kidney injury (AKI) by using Nafamostat Mesilate (NM). Methods. Eighty AKI who underwent CRRT from March 2022 to January were divided into control group (n = 40, treated unfractionated heparin) and Observation NM). The duration first filter use, number filters used 72 hours after treatment, coagulation functions, adverse reactions, bleeding events, length stay intensive care unit (ICU)...

Gene editing contributes to enhancing food security through the creation of novel foods. However, public perception gene-edited (GE) foods is crucial their acceptance and adoption. This study expanded knowledge–attitude–practice model constructed an integrated framework comprising four dimensions: demographic factors, scientific literacy beliefs, social trust, perceptions gene technology, aimed at explaining public’s attitudes toward GE A questionnaire survey was conducted (N = 649),...

Elucidating the signalling pathways that regulate chondrocyte differentiation, such as actin cytoskeleton and Rho GTPases, during development is essential for understanding of pathological conditions cartilage, chondrodysplasias osteoarthritis.Manipulation dynamics in tibia organ cultures isolated from E15.5 mice results pronounced enhancement endochondral bone growth specific changes plate architecture.Global gene expression were examined primary chondrocytes embryonic tibia, treated with...

Abstract The use of empty space (ES) is ubiquitous in Asian art. authors a computational method to quantitatively assess the amount ES Chinese landscape painting (CLP). data show that 56.8% ancient CLPs contain mostly ES, while only 9.4% from modern times do. reached its peak during Yuan dynasty (1271–-1368) and lowest point 1960s. Chan culture, literati ink play, “exhibition hall effect,” Maoist politics, as well other social factors, may have had an impact on this shift. This empirical...

The adverse effects of deepfakes are becoming apparent; however, less is known about what affects individuals’ credibility judgments concerning deepfakes. This article conducted two randomized controlled 2 × experiments ( N = 518) to explore the influence heuristic cues (including number followers, popularity, and description as variables) generated by system video characteristics definition, duration, editing variables). results suggest that source’s followers video’s popularity positively...

Abstract Background In the era of evidence-based policy-making (EBPM), scientific outputs and public policy should engage with each other in a more interactive coherent way. Notably, this is becoming increasingly critical preparing for health emergencies. Methods To explore coevolution dynamics between science (SAP), study explored changes in, development of, COVID-19 research early period outbreak China, from 30 December 2019 to 26 June 2020. study, VOSviewer was adopted calculate link...

Our statistical analysis of research publications in the prestigious scientific journals Nature, Science and Cell reveals that papers represented by an image on journal’s cover gain many more citations academic literature than those same are not cover. Meanwhile, number images used high-prestige is much higher general, which indicates both emergence a new aesthetic prestige publication, also this relevant to journals’ impact. Furthermore, there significant differences use different countries...

Controversies around genetically modified (GM) food have become particularly prevalent in China. To understand the situation, 257 GM cartoons were collected from various Chinese online sources. We found that China’s peaked during controversial social events end of 2012 to 2016, which is consistent with Baidu Media Index on headline news. About 85% involve and more than half share scary information. The mainstream media neutral not only presents dilemma choice but also promotes organisms...

Abstract: The one-child era, which lasted thirty-five years (1980–2015), was a unique period in Chinese (and even world) history. With the introduction of universal two-child policy 2016, China put an end to age policy. Since change has come into effect, China's rural areas, contain approximately 800 million people, have experienced very particular historical phenomenon. Due changes family planning policy, slogans painted on walls evolved terms messages they carry grassroots areas. Once...