A5012432236- Protein Kinase Regulation and GTPase Signaling
- Enzyme Structure and Function
- Protein Structure and Dynamics
- Biochemical and Molecular Research
- Synthesis and Reactivity of Heterocycles
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Metal complexes synthesis and properties
- Cancer, Hypoxia, and Metabolism
- Ubiquitin and proteasome pathways
- Glycogen Storage Diseases and Myoclonus
- HER2/EGFR in Cancer Research
- Autophagy in Disease and Therapy
- Carbohydrate Chemistry and Synthesis
- Enzyme function and inhibition
- Monoclonal and Polyclonal Antibodies Research
- Synthesis and biological activity
- Organometallic Complex Synthesis and Catalysis
- Click Chemistry and Applications
- PI3K/AKT/mTOR signaling in cancer
- Ferrocene Chemistry and Applications
- Chronic Lymphocytic Leukemia Research
- BIM and Construction Integration
University of Cologne
2014-2021
Fischer (Germany)
2015
A new series of TBB-derivatives was synthesized and characterized as CK2 inhibitors. Crystallographic analysis docking studies were used to understand the mode binding.
Human protein kinase CK2 is an emerging target for neoplastic diseases. Potent lead structures human inhibitors are derived from dibenzofuranones. Two new derivatives, 7,9-dichloro-1,2-dihydro-8-hydroxy-4-[(4-methoxyphenylamino)-methylene]dibenzo[b,d]furan-3(2H)-one (4a) and (E)-1,3-dichloro-6-[(4-methoxyphenylimino)-methyl]dibenzo[b,d]furan-2,7-diol (5) were tested inhibition of induction apoptosis in LNCaP cells. Both turned out to be tight binding inhibitors, with IC50 values 7 nM 5...
Zusammenfassung Im Vergleich zu anderen produzierenden Industrien stagniert im Bauwesen die Arbeitsproduktivität je Erwerbstätigem seit Jahren. Trotz der in Praxis zunehmenden digitalen Planung mithilfe von Building Information Modeling (BIM), liegen Gründe unter anderem unzureichenden Standardisierung und damit einhergehenden fehlenden Automatisierung Prozessen Berechnungen. Resultat dessen sind weiterhin punktuelle deterministische Baukostenberechnungen, welche meist auch erst späten...