A5049587711- Estrogen and related hormone effects
- Protein Kinase Regulation and GTPase Signaling
- Synthesis and Reactions of Organic Compounds
- Steroid Chemistry and Biochemistry
- Molecular Sensors and Ion Detection
- Synthesis and biological activity
- Bioactive Compounds and Antitumor Agents
- Fungal Biology and Applications
- Advanced biosensing and bioanalysis techniques
- Cancer therapeutics and mechanisms
- Antifungal resistance and susceptibility
- Click Chemistry and Applications
- Polysaccharides and Plant Cell Walls
- Synthesis and Characterization of Heterocyclic Compounds
- Fungal and yeast genetics research
- Enzyme function and inhibition
- Fungal Infections and Studies
- Biochemical and Molecular Research
- Synthesis and Biological Evaluation
- Monoclonal and Polyclonal Antibodies Research
- Quinazolinone synthesis and applications
- Phenothiazines and Benzothiazines Synthesis and Activities
- Peptidase Inhibition and Analysis
- Luminescence and Fluorescent Materials
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
John Paul II Catholic University of Lublin
2016-2025
Universidad San Pablo CEU
2010-2015
Universidad San Pablo
2015
A new series of coumarin-1,2,3-triazole conjugates with varied alkyl, phenyl and heterocycle moieties at C-4 the triazole nucleus were synthesized using a copper(I)-catalysed Huisgen 1,3-dipolar cycloaddition reaction corresponding O-propargylated coumarin (3) or N-propargylated (6) alkyl aryl azides. Based on their minimal inhibitory concentrations (MICs) against selected microorganisms, six out twenty-six compounds showed significant antibacterial activity towards Enterococcus faecalis...
A new naphthoquinone-based chemosensor 2-((3-hydroxyphenyl)amino)-3-(phenylthio)naphthalene-1,4-dione (2HPN) was successfully synthesized for the selective detection of Fe2+. The sensing property 2HPN evaluated in aqueous acetonitrile (CH3CN) medium by a fluorescence emission method. metal-binding studies ligand showed "turn-on" responses Fe2+ (Ka = 1.0 × 106 M–1). limit to calculated be 0.272 μM, which is lower than World Health Organization recommendation (0.3 mg/L) drinking water. most...
An easily accessible colorimetric and fluorescence probe 4-((3-chloro-1,4-dioxo-1,4-dihydronaphthalen-2-yl)amino)benzenesulfonamide (4CBS) was successfully developed for the selective sensitive detection of Sn2+ in an aqueous solution. The sensing mechanism involves reduction −C═O into −C–OH groups 4CBS upon addition Sn2+, which initiates turn-on mode. A better linear relationship achieved between intensity concentration range 0–62.5 μM, with a limit (LOD) 0.115 μM. binding confirmed by...
Abstract Emodin (1,3,8‐trihydroxy‐6‐methyl‐anthraquinone) is a natural secondary plant product, originally isolated from the rhizomes of Rheum palmatum . Many reports show its diuretic, vasorelaxant, antibacterial, antiviral, anti‐ulcerogenic, immunosuppressive, hepatoprotective, anti‐inflammatory and anticancer potential. pleiotropic molecule capable interacting with several major molecular targets, e.g. NF‐ κ B, AKT/mTOR STAT3. The compound can also act as an inhibitor some protein...
1,4-Naphthoquinones are an important class of compounds present in a number natural products. In this study, new series 1,4-naphthoquinone derivatives were synthesized. All the synthesized tested for vitro antimicrobial activity. investigation, two Gram-positive and five Gram-negative bacterial strains one pathogenic yeast strain used to determine antibacterial Naphthoquinones its potencies, among seven them displayed better activity against Staphylococcus aureus (S. aureus; 30-70 μg/mL)....
Abstract Aquatic plants are a rich source of health-beneficial substances. One such organisms is the submerged macrophyte Ceratophyllum demersum , which has not been sufficiently studied in this aspect so far. In work, we have environmental conditions prevailing subsidence mining reservoir Eastern Poland and shown that C. can be harvested for further analysis even from artificial anthropogenic reservoirs. The phytochemical ethanolic extract using LC–MS revealed high content phenolic...
The huge health-beneficial potential of polysaccharides encourages the search for novel sources and applications these compounds. One poorly explored source is rose. content biological activity in rose organs an almost completely unaddressed topic, therefore, polysaccharide-rich extracts (crude polysaccharides, CPLs) from petals, leaves, hips, achenes Rosa rugosa Thunb. were studied their composition influence on various cellular processes involved development cancer other civilization...
A new type of silver nanoparticles (AgNPs) was prepared and comprehensively studied. Scanning electron microscopy (SEM) dynamic light scattering (DLS) analyses indicated that 24 nm AgNPs with narrow size distribution were obtained while Z-potential confirms their good stability. The composites the nontoxic-nature-inspired hydrogel formed upon cooling aqueous solution C12Ala. thermal gravimetric analysis (TGA) differential scanning calorimetry (DSC) do not show significant shifts in...
The design of multitarget drugs (MTDs) has become an innovative approach for the search effective treatments in complex diseases such as cancer. In this work, we communicate our efforts multi-targeting histone deacetylase (HDAC) and protein kinase CK2 inhibitors a novel therapeutic strategy against Using tetrabromobenzotriazole (TBB) 2-dimethylamino-4,5,6,7-tetrabromo-benzimidazole (DMAT) scaffolds inhibition, hydroxamate to coordinate zinc atom present active site HDAC (zinc binding group,...
A simple naphthoquinone–dopamine hybrid (2CND) was designed and fabricated as a colorimetric fluorescence chemosensor for the selective recognition of Sn2+ in aqueous medium. This simply accessible prepared by connecting naphthoquinone acceptor dopamine donor moieties via Michael-like addition reaction. The 2CND showed turn-on response which operated through inhibited photoinduced electron transfer effect. sensor probe shows remarkable performance, such high selectivity, sensitivity,...
Infections caused by Candida species have increased significantly in the past decades and are among leading causes of morbidity mortality worldwide, resulting serious public health problems. Currently, conventional antifungals often ineffective as spp. developed growing resistance to systemic drugs. Since inorganic metallacarboranes known affect cellular events, new derivatives these abiotic compounds were tested against albicans. Compounds based on cobalt bis-dicarbollide [COSAN] studied...
Armillaria mellea is a commonly harvested and consumed mushroom in Poland. Several activities of polysaccharides from this species have already been reported. However, A. growing the wild Poland not yet investigated. This study was conducted to obtain crude polysaccharide fraction (AmPS) investigate its chemical composition biological properties. Our research suggests that valuable source polysaccharides, including β-glucans. 1H NMR high-performance capillary electrophoresis analysis AmPS...
A new series of TBB-derivatives was synthesized and characterized as CK2 inhibitors. Crystallographic analysis docking studies were used to understand the mode binding.
Benzimidazole derivatives of 5,6-dichlorobenzimidazole 1-β-d-ribofuranoside (DRB) comprise the important class protein kinase CK2 inhibitors. Depending on structure, benzimidazoles inhibit with different selectivity and potency. Besides CK2, compounds can inhibit, similar activity, other classical eukaryotic kinases (e.g. PIM, DYRK, PKD). The present results show that a majority most common inhibitors affect atypical Rio1 in nanomolar range. Kinetic data confirmed mode action as typical...