A5100679307- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Advanced biosensing and bioanalysis techniques
- Biosensors and Analytical Detection
- DNA and Nucleic Acid Chemistry
- Electrochemical Analysis and Applications
- Molecular Sensors and Ion Detection
- Crystallography and molecular interactions
- Advanced Chemical Sensor Technologies
- Electrochemical sensors and biosensors
- Nanocomposite Films for Food Packaging
- Supramolecular Self-Assembly in Materials
- Genomic variations and chromosomal abnormalities
- Collagen: Extraction and Characterization
- Nanocluster Synthesis and Applications
- Molecular Junctions and Nanostructures
- Advanced Biosensing Techniques and Applications
- Boron and Carbon Nanomaterials Research
- Manufacturing Process and Optimization
- Graphene research and applications
- Advanced Nanomaterials in Catalysis
- Microtubule and mitosis dynamics
- Hydrogels: synthesis, properties, applications
- Diamond and Carbon-based Materials Research
- Dermatology and Skin Diseases
Fourth Hospital of Changsha
2025
Hunan Normal University
2025
Chongqing University
2024
Chongqing Cancer Hospital
2024
Xiangtan University
2019-2023
Shandong University of Technology
2023
Xiangya Hospital Central South University
2023
Hunan Children's Hospital
2019-2023
Central South University
2023
University of South China
2023
Because of the intrinsic importance nucleic acids as biotargets, simple and sensitive detection is very essential for biological studies medical diagnostics. In this work, a novel, simple, selective electrochemical DNA biosensor target (T-DNA) has been developed based on dual-signaling ratiometric method exonuclease III (Exo III)-assisted recycling amplification strategy. The assay strategy includes both "signal-on" "signal-off" elements. stem-loop (hairpin) capture probe (HP), which was...
Abstract Killer cell lectin-like receptor G1 (KLRG1) is an immune checkpoint expressed predominantly in NK and T-cell subsets that downregulates the activation proliferation of cells participates cell-mediated responses. Accumulating evidence has demonstrated importance KLRG1 as a noteworthy disease marker therapeutic target can influence onset, progression, prognosis. Blocking been shown to effectively mitigate effects downregulation various mouse tumor models, including solid tumors...
Traditional aqueous self-assembly of tubular structures (as well as other aggregates) usually relies on the hydrophobic effect, a relatively weak and nondirectional interaction. The resultant aggregates are inherently soft, fluid, less-ordered. Alternatively, we report novel kind nonamphiphilic microtubes in solutions cyclodextrin/ionic surfactant (CD/IS) complexes. This is driven exclusively by H-bonds, strong, directional interactions. CD/IS feature an unbundling nature, ultralong...
A simple and label-free electrochemical biosensor based on a dopamine DNA aptamer was developed for the sensitive selective detection of dopamine.
Abstract A novel competitive host-guest strategy regulated by protein biogate was developed for sensitive and selective analysis of prion protein. The methylene blue (MB)-tagged aptamer (MB-Apt) introduced to the multiwalled carbon nanotubes-β-cyclodextrins (MWCNTs-β-CD) composites-modified glassy (GC) electrode through interaction between β-CD MB. In absence prion, MB-Apt could be displaced ferrocenecarboxylic acid (FCA) due its stronger binding affinity β-CD, resulting in a large oxidation...
A label-free strategy for evaluation of DNA methyltransferase activity was developed based on electrocatalytic oxidation ascorbic acid by graphene.
An electrochemical biosensor for Hg<sup>2+</sup> detection was developed based on Exo III-assisted target recycling and hybridization chain reaction amplification strategies.
A simple, low-cost technique has been developed for the rapid fabrication of single-layered paper-based microfluidic devices (μPADs). This technique, first time, made use deposition patterned adhesive tape into filter paper to construct hydrophobic barriers, with help toluene. Unlike other reported multi-layered μPADs that merely as a separate layer sealing or fluid flow controlling, was simultaneously dissolved and penetrated paper, which resulted in successful transfer pattern from paper....
The concentrations of nitrite and thiocyanate in saliva can be used as the biomarkers progression periodontitis disease environmental tobacco smoke exposure, respectively. Therefore, it is particularly necessary to detect these two indicators saliva. Herein, three-dimensional single-layered paper-based microfluidic analytical devices (3D sl-μPADs) were, for first time, fabricated by spraying technique colorimetric detection at same time. conditions 3D sl-μPADs fabrication were optimized...
Objectives Autism is a severe neurodevelopmental disorder. Many susceptible or causative genes have been identified, and most of them are related to synaptogenesis. The THBS1 gene encodes thrombospondin 1, which plays critical role in synaptogenesis the central nervous system developing brain. However, no study has carried out revealing that an autism risk gene. Methods We analyzed whole coding region 5′-untranslated 313 autistic patients by Sanger sequencing, was also used analyze...
A novel, simple, and low-cost spray painting technique has been developed for the fabrication of microfluidic paper-based devices. The devices that we utilize aerosol paint to build hydrophobic barriers employ a hole puncher obtain patterned layers paper dots without using any specialized instruments (e.g., laser cutter). entire manufacturing process is extremely inexpensive, rapid, which means it can be applied broadly. Furthermore, application device iron detection was demonstrated. linear...
In this study, we report a novel three-component luminescent hydrogel, which is composed of amino acid derivatives (N,N'-di valine-3,4,9,10-perylenetetracarboxylic acid, NVPD), riboflavin (RF), and melamine (MM). The hydrogel attributed to multiple hydrogen bonds the strong π-π stacking interaction between these molecules. Based on bonding gelator, when reversible process gel solution take places it changes pH system from 6.1 10.6. addition, green fluorescence could be emissive under 498 nm...
In this study, we report on mosaic variegated aneuploidy (MVA) syndrome with tetraploidy and predisposition to infertility in a family. Sequencing analysis identified that the CEP192 biallelic variants (c.1912C>T, p.His638Tyr c.5750A>G, p.Asn1917Ser) segregated microcephaly, short stature, limb-extremity dysplasia, reduced testicular size, while monoallelic and/or size 1,264 unrelated patients, variant screening for same (c.5750A>G, other significantly associated infertility. Two lines of...
A traditional external standard method using HPLC coupled with evaporative light scattering detection has been developed for fast and accurate determination of seven platycosides in Platycodi Radix. However, inevitable difficulties reference standards preparation process, which are quite costly time consuming, have made its application limited. To avoid this inconvenience, a simultaneous multiple components single strategy, could be realized by calibrating the curve internal response...
A maskless fabrication method was developed to produce silver electrodes on paper substrates capable of detecting 16 nM Pb<sup>2+</sup>.
Fish gelatin (FG) film has received an increasing attention in the last decades due to its biodegradability and environmental friendliness, which is a prospective replacer of petroleum-based plastics. This work for first time investigated effect chloride salt type on properties FG film. films incorporated with three kinds salts (CaCl2, KCl, NaCl) various concentrations were prepared by casting. The light barrier property, mechanical swelling behaviour, color scanning electron microscopic...