A5005572477- Genetic Neurodegenerative Diseases
- Asthma and respiratory diseases
- Mitochondrial Function and Pathology
- Metabolism and Genetic Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Dementia and Cognitive Impairment Research
- Immunodeficiency and Autoimmune Disorders
- Alzheimer's disease research and treatments
- Psoriasis: Treatment and Pathogenesis
Universitätsklinikum Erlangen
2020
Friedrich-Alexander-Universität Erlangen-Nürnberg
2020
University of Würzburg
2013-2014
The hallmarks of sporadic Alzheimer's disease (AD) are extracellular amyloid deposits, intracellular neurofibrillary tangles (NFTs), and neuronal death. Hyperphosphorylation tau is a key factor in the generation NFTs. Mitogen activated protein kinase 1 (MAPK1) C beta (PRKCB) thought to play role hyperphosphorylation, PRCKB be involved hypoxic stress vascular dysfunction, trigger MAPK phosphorylation pathways. We performed single-cell analyses neurons with different vulnerabilities AD-related...