A5101821401- COVID-19 and Mental Health
- Congenital heart defects research
- Genomic variations and chromosomal abnormalities
- Neural and Behavioral Psychology Studies
- Congenital Heart Disease Studies
- Circadian rhythm and melatonin
- Long-Term Effects of COVID-19
- Autism Spectrum Disorder Research
- Optical Imaging and Spectroscopy Techniques
- Neuroinflammation and Neurodegeneration Mechanisms
- Physiological and biochemical adaptations
- Genetics, Aging, and Longevity in Model Organisms
- Alzheimer's disease research and treatments
- Human-Automation Interaction and Safety
- Dementia and Cognitive Impairment Research
- Cognitive and psychological constructs research
- Sociology and Education Studies
- Health and Medical Studies
- Memory and Neural Mechanisms
- Blood Pressure and Hypertension Studies
- Psychosomatic Disorders and Their Treatments
- Neurotransmitter Receptor Influence on Behavior
- Teleoperation and Haptic Systems
- Sports Science and Education
- Patient Dignity and Privacy
University of Rostock
2020-2023
University of Würzburg
2011-2020
Memories are thought to be due lasting synaptic modifications in the brain. The search for memory traces has relied predominantly on determining regions that necessary process. However, a more informative approach is define smallest sufficient set of brain structures. rutabaga adenylyl cyclase, an enzyme ubiquitously expressed Drosophila and mediates plasticity, needed exclusively Kenyon cells mushroom bodies component olfactory short-term memory. This demonstrates plasticity small region...
Abstract An approach bias for alcohol stimuli (i.e. faster than avoidance reactions) might facilitate relapses in dependence. Neurobiological models suggest hypersensitivity the reward system [inter alia nucleus accumbens and orbitofrontal cortex ( OFC )] to cause pathologically enhanced impulses towards stimuli. At same time, dependence, these structures are only insufficiently controlled by a hypoactive dorsolateral prefrontal DLPFC ). The present study investigated cortical aspects of...
The hallmarks of sporadic Alzheimer's disease (AD) are extracellular amyloid deposits, intracellular neurofibrillary tangles (NFTs), and neuronal death. Hyperphosphorylation tau is a key factor in the generation NFTs. Mitogen activated protein kinase 1 (MAPK1) C beta (PRKCB) thought to play role hyperphosphorylation, PRCKB be involved hypoxic stress vascular dysfunction, trigger MAPK phosphorylation pathways. We performed single-cell analyses neurons with different vulnerabilities AD-related...
The COVID-19 pandemic has raised significant concerns for population mental health and the effective provision of services in light increased demands barriers to service delivery [1]. Particular attention is being directed toward possible neuropsychiatric sequelae both stringent societal mitigation steps deployed by national governments, that are informed historical increases incidence psychotic disorders following influenza pandemics [2]. However, so far there been scant paid other...
Background: Research participant feedback is rarely collected; therefore, investigators have limited understanding regarding stakeholders’ (affected individuals/caregivers) motivation to participate. Members of the Genes Mental Health Network (G2MH) surveyed stakeholders affected by copy number variants (CNVs) perceived incentives for study participation, opinions concerning research priorities, and necessity future funding. Respondents were also asked about feelings preparedness, burden,...
The 22q11.2 microduplication syndrome shows variable phenotypes with reduced penetrance compared to the deletion syndrome. We report a woman overgrowth and macrocephaly, mild mental retardation, heart defect, kidney anomalies, dysmorphic features. Array-CGH analysis revealed 246-kb duplication at region. No additional clinically significant CNVs were found. case resembles previously published also showing macrocephaly an almost identical of 252 kb.
Abstract Background The world has suffered immeasurably during the COVID‐19 pandemic. Increased distress and mental medical health concerns are collateral consequences to disease itself. Genes Mental Health (G2MH) Network consortium sought understand how individuals affected by rare copy number variations of 22q11.2 deletion duplication syndrome, associated with neurodevelopmental/neuropsychiatric conditions, were coping. article focuses on worry disruptions in care caused Methods University...
Introduction/objectives Neurotoxic effects of alcohol consumption are well-known. There is plenty literature on frontal lobe impairment the behavioral and structural brain imaging level. However, only few functional studies investigated altered neural patterns even less abstinence-related recovery. Here, we if activity tends to normalize in patients that remain successfully abstinent. Methods In a cross-sectional design three patient groups (acute withdrawal, detoxified, abstinent) healthy...
Users perceiving mechanical controls as high quality is critical in au-tomotive engineering. This study examines how 30 participants rated three air vents taken from one vehicle segment. Results indicate that the haptic sense had greatest influence on judgement of quality. Participants were even able to detect differentiation actuation path length and forces. Technical parame-ters identified promise favorable impressions. Future research should use a test-rig enable specific manipulation...