A5041178058- HIV Research and Treatment
- HIV, TB, and STIs Epidemiology
- Immunodeficiency and Autoimmune Disorders
- HIV/AIDS Research and Interventions
- Pneumocystis jirovecii pneumonia detection and treatment
- Pediatric health and respiratory diseases
- HIV/AIDS drug development and treatment
- HIV, Drug Use, Sexual Risk
- Cytomegalovirus and herpesvirus research
- Syphilis Diagnosis and Treatment
- Parvovirus B19 Infection Studies
- Tuberculosis Research and Epidemiology
- Bacterial Infections and Vaccines
- Eosinophilic Esophagitis
- Viral-associated cancers and disorders
- Hepatitis C virus research
- Blood groups and transfusion
- Pneumonia and Respiratory Infections
- Respiratory viral infections research
- Viral Infections and Immunology Research
- Infectious Encephalopathies and Encephalitis
- Psychiatric care and mental health services
- Infant Health and Development
- Diphtheria, Corynebacterium, and Tetanus
- Immune responses and vaccinations
Rostov State Medical University
2010-2024
Ministry of Health of the Russian Federation
2021-2023
Centre for Prevention and Control of AIDS and Infectious Diseases
2010
The heavy burden of meningococcal infection is associated not only with life-threatening complications in the acute period and high mortality invasive forms disease, but also severe consequences survivors, who are recorded our country.The aim study: to analyze clinical manifestations, outcomes disease children various regions Russian Federation.Materials methods: an analysis data from 1327 inpatient medical records 14 regional centers Federation for 2012-2021 was carried out (28.3% cases...
Widespread, severe course, frequent development of chronic forms, adverse effects the Epstein-Barr virus infection to health children, difficulties diagnosis and therapy dictate need improve diagnostic treatment programs in this disease. A total 286 patients with acute infection. It was established, that for timely disease requires a comprehensive analysis anamnesis, clinical symptoms, including symptoms mononucleosis syndrome combination multiorgan pathology, results laboratory examination...
The sporadic incidence of tetanus, the identity symptoms with clinical picture a number common neuroinfections, high frequency various background pathologies create difficulties in disease diagnosing children. On case history example 3 years 9 months old child two diseases (tetanus, enterovirus infection) that developed against active form herpesvirus infection, an algorithm diagnostic and therapeutic measures is presented. A differential diagnosis was made between generalized tetanus...
Objective : the study of molecular epidemiological and clinical aspects EVI in Rostov region for period 2006-2020. to improve disease surveillance system. Research methods: epidemiological, virological, biological (PCR, sequencing, phylogenetic analysis), microbiological, statistical. Materials methods analysis medical records 139 patients with was carried out. Samples biomaterial (feces, throat swab) from 17293 people, samples environmental objects (2710 samples), strains enteroviruses (EV)...
Эффективность комплексного использования инозина пранобекса и рекомбинантного интерферона-2b при хронической Эпштейна-Барр вирусной инфекции у часто болеющих детей Э. Н. СИМОВАНЬЯН, В. Б
The purpose of research — improvement CNS pathology diagnostic in children with enterovirus-71 infection during epidemic and interepidemic periods. study involved 64 patients at the age from 6 months to 14 years pathology, including 52 period 12 period. disease is characterized by appearance first two days fever, murrian-like, catarrhal, lymphoproliferative syndromes. On third day illness joined symptoms meningitis, meningoencephalitis, encephalomyelopoliradiculoneuropathy neuropathy. often...
The purpose is to characterize the features of clinical picture, interferon and immune system status in shigellosis associated with herpesvirus infections children, justify inclusion recombinant interferon-a2b (VIFERON®) complex treatment program disease. Clinical immunological examination 136 patients at age from 1 3 years was carried out. In 65 children active form infection diagnosed, 20 it absent. Active developed a burdened premorbid background. These showed violation response...
The objective — to characterize the effectiveness of different schemes antiretroviral therapy in children with HIV infection and on basis obtained data improve disease treatment. Patients Methods: A clinical, immunological virological examination 45 were carried. received abacavire lamivudine combination lopinavir/ritonavir (24 patients) or nevirapine (21 children). Results: Using both leads suppression replication, improvement clinical parameters. However, treatment revealed a significant...
Modern features of purulent meningoencephalitis is the frequent development disease at adverse premorbid background, formation a mixed infection, which leads to severe prolonged duration, occurrence complications. For example medical history two years old child with acute etiology (Str. Pneumoniae, H. influenzae type b), developed on background chronic herpes virus rezudual-organic CNS pathology, submitted algorithm diagnostic and therapeutic measures in these cohort patients.
Clinical, immunological and virologic examination of 67 HIV infected children receiving highly activity antiretroviral therapy (HAART) within 12—60 months is conducted. HAART promoted suppression replication, increase T-helpers count, reduction clinical symptoms frequency its expressiveness. At long application the considerable part patients needs correction because loss efficiency starting scheme or development side effects. For it necessary lopinavir/ritonavir to include in schemes, also...
The purpose is to clarify the immunopathogenetic significance of immunocompetent cells activation and apoptosis in children with HIV-infection. Materials methods . A clinical immunological examination 92 aged 1 5 years old HIVinfection latent stage 3 (25), secondary diseases 4A (21), 4B (22) 4V (24) was conducted. Results. During examination, consistent appearance HIV-associated symptoms, opportunistic infections, tumors noted. Changes immune status included abnormalities T-cell component –...
The purpose of the study is to improve diagnosis and prognosis opportunistic infections in children infected with HIV by vertical parenteral routes, taking into account dynamics clinical immunological parameters.Research methods. Clinical laboratory examinations were carried out 192 route (91; group I), infancy (44; II) over age one year (57; III).Research results. In I, a rapid development immunosuppression was observed: mild immunodeficiency diagnosed at Me 4 (IQI 2—10) months, advanced —...
The purpose is to characterize the clinical picture, immune status and natural history of HIV infection in stage secondary diseases vertical parenteral infected children. Materials methods. A clinical, laboratory, instrumental, immunological examination 132 children with a way (90; I group) infancy (42; II was carried. Results. picture included various combinations HIV-associated symptoms, opportunistic infections, tumors, which determines symptomatology particular stage. use Cox regression...
The purpose of the research – to characterize factors that influence effectiveness starting highly activе antiretroviral therapy in children with HIV infection. Materials and methods. A total 67 infection at age from 24 36 months who have not received antiretroviral treatment. Patients received highly activе antiretroviral therapy on clinical, immunological laboratory indications. Regimen consisted two nucleoside reverse transcriptase inhibitors (zidovudine lamivudine) in combination a...
научный биометрический журнал, который знакомит читателя с клиническими рекомендациями и особенностями применения лекарственных вакцинных средств у детей, предоставляет исчерпывающую информацию о воздействии на плод, проводимых в
91 children vertically infected with HIV were examined. 26% of the patients, developed infection rapidly its subsequent development into AIDS in first two years life. Multifactorial logistic regression model demonstrated that independent predictors rapid HIV-infection progression blood viral load 300 000 cop./ml and CD4+-lymphocytes count 20% age six months. The use level as a prognostic test is preferred because higher sensitivity (91,3%) specificity (97,1%).
The goal is to improve the prediction of immune status state dynamics in children with HIV infection, taking into account results clinical and laboratory examination. Materials methods. Clinical, immunological molecular genetic examination was carried 81 infection at age median Me 22 months (interquartile interval IQI 13—42 months). duration observation patients 10 ( 4—12 time before development severe immunosuppression according WHO classification determined. criterion for a decrease...
Objective. To determine the clinical and microbiological features of duration respiratory infections in children with different vaccination history. Patients methods. Children (106 people) inflammatory diseases tract were examined, 64 them vaccinated accordance, 42 people deviations from National schedule vaccinations. The oropharyngeal discharge saliva examined PCR to detect RNA DNA viral bacterial pathogens. We used test systems produced by Federal State Budgetary Institution...