A5055780911- Antifungal resistance and susceptibility
- Cystic Fibrosis Research Advances
- Nematode management and characterization studies
- Plant Pathogens and Fungal Diseases
- Fungal Infections and Studies
- Single-cell and spatial transcriptomics
- Infectious Diseases and Mycology
- Gene Regulatory Network Analysis
- Infections and bacterial resistance
- RNA Research and Splicing
- Cytokine Signaling Pathways and Interactions
- Cell Image Analysis Techniques
- Plant Pathogenic Bacteria Studies
- Plant Disease Resistance and Genetics
- Bacterial Identification and Susceptibility Testing
- Chromatin Remodeling and Cancer
- PARP inhibition in cancer therapy
- Antibiotic Resistance in Bacteria
- Enzyme-mediated dye degradation
- Toxin Mechanisms and Immunotoxins
- Invertebrate Immune Response Mechanisms
- Genomics and Chromatin Dynamics
- Ovarian cancer diagnosis and treatment
- Mycobacterium research and diagnosis
- Insect and Pesticide Research
Inserm
2002-2024
Université d'Angers
2012-2024
Université de Bretagne Occidentale
2021-2024
Ischémie Reperfusion, Métabolisme et Inflammation Stérile en Transplantation
2024
Centre Hospitalier Universitaire d'Angers
2004-2024
Hospices Civils de Lyon
2020-2022
Université Claude Bernard Lyon 1
2004-2022
École Normale Supérieure de Lyon
2017-2022
Centre National de la Recherche Scientifique
2008-2022
Interaction Hôtes Agents Pathogènes
2013-2022
Signal transducer and activator of transcription 3 (STAT3) factors are cytoplasmic proteins that induce gene activation in response to cytokine receptor stimulation. Following tyrosine phosphorylation, STAT3 dimerize, translocate the nucleus, activate specific target genes. This transcriptional by has been shown require recruitment coactivators such as CREB-binding protein (CBP)/p300. In present study, we show steroid coactivator 1, NcoA/SRC1a, originally identified a nuclear coactivator,...
ABSTRACT We report eight cases of airway colonization by Geosmithia argillacea in patients with cystic fibrosis. This filamentous fungus, resembling members the genera Penicillium and Paecilomyces , was identified molecular analysis. All carried a mutation on each CFTR (cystic fibrosis transmembrane conductance regulator) allele, at least one copy F508del mutation. The first isolation this fungus occurred from F508del-homozygous younger age than F508del-heterozygous patients. Before recovery...
Species of the Pseudallescheria boydii/Scedosporium apiospermum complex (PSC) are emerging fungal pathogens able to chronically colonize airways patients with cystic fibrosis (CF). As P. boydii was found more frequently colonizing lungs CF in France than other European countries a previous report, present study conducted order clarify distribution PSC species and characterize their natural habitat. The highest densities isolates were human-impacted areas, i.e. agricultural fluids obtained...
As various new sibling species within the Pseudallescheria boydii/Scedosporium apiospermum complex have been described recently with differences in their susceptibility to antifungals, this study was conducted order determine respective frequency cystic fibrosis. Results indicated that P. boydii largely predominated (62%), followed by S. (24%), Scedosporium aurantiacum (10%) and minutispora (4%). dehoogii not recovered study. The multiple correspondence factor analysis highlighted...
ABSTRACT In recent years, Geosmithia argillacea has been increasingly reported in humans and animals can be considered an emerging pathogen. The taxonomy of was recently studied, related species were transferred to the new genus Rasamsonia . diversity among a set strains, including 28 clinical antifungal susceptibility profiles generated. Data obtained from morphological studies phylogenetic analyses internal transcribed spacer (ITS) partial β-tubulin calmodulin sequences revealed presence...
To better understand the mechanisms behind cells decision-making to differentiate, we assessed influence of stochastic gene expression (SGE) modulation on erythroid differentiation process. It has been suggested that a role in cell fate which is revealed by single-cell analyses but studies dedicated demonstrate consistency this link are still lacking. Recent observations showed SGE significantly increased during and few an increase level accompanied However, consistent relation both...
Chronic myelogenous leukemia arises from the transformation of hematopoietic stem cells by BCR-ABL oncogene. Though transformed are predominantly BCR-ABL-dependent and sensitive to tyrosine kinase inhibitor treatment, some BMPR1B+ leukemic treatment-insensitive rely, among others, on bone morphogenetic protein (BMP) pathway for their survival via a BMP4 autocrine loop. Here, we further studied involvement BMP signaling in favoring residual cell persistence marrow patients having achieved...
Besides its function as a cell cycle regulator, cyclin D1 interacts with transcription factors to regulate gene activation. In this study, we show that is recruited the p21waf1 promoter by STAT3-NcoA complex. The association of DNA prevented recruitment CBP histone acetylase and RNA polymerase II, leading an inhibition gene. Confirming transcriptional protein, expression was enhanced in D1–/– fibroblasts or upon siRNA-mediated down-regulation cyclin. Moreover, STAT3-mediated activation also...
Scedosporium species are opportunistic pathogens causing various infections, including disseminated infections in severely immunocompromised patients. Preventive measures aiming to reduce the risk of exposure these fungi require a better knowledge on their ecology and sources contamination In this context, 99 soil samples from Rabat-Sale-Kenitra Fez-Meknes regions Morocco were analyzed. Samples inoculated highly selective Scedo-Select III culture medium, seven chemical parameters soils...
Scedosporium species are common fungal pathogens in patients with cystic fibrosis (CF). To colonize the CF lungs, fungi must cope host immune response, especially reactive oxygen (ROS) released by phagocytic cells. this aim, have developed various antioxidant systems, including superoxide dismutases (SODs) which constitute first-line protection against oxidative stress. Interestingly, one of S. apiospermum SOD-encoding genes (SODD gene) exhibits a glycosylphosphatidylinositol (GPI)...
Cystic fibrosis (CF) patients are at high risk of colonization the airways by a number fungi, including emerging opportunistic fungus Geosmithia argillacea. We report eradication respiratory G. argillacea associated with clinical resolution severe symptoms high-dose and prolonged micafungin therapy in young CF patient.
ABSTRACT The aim of this work was to document molecular epidemiology Rasamsonia argillacea species complex isolates from cystic fibrosis (CF) patients. In work, 116 belonging and collected 26 CF patients one patient with chronic granulomatous disease were characterized using PCR amplification assays repetitive DNA sequences electrophoretic separation amplicons (rep-PCR). Data revealed a clustering consistent identification. A single recovered most aegroticola the common species, followed by...
Abstract. Objectives : Stem cell antigen 2 (SCA2), also known as TSA1 and LY6E, is a glycosylphosphatidylinositol‐anchored molecule that belongs to the Ly‐6 family whose function remains largely unknown. We have previously shown SCA2 overexpressed in self‐renewing avian erythroid progenitors (T2ECs) opposed differentiating T2ECs. The aim of this study was define role switch between self‐renewal differentiation progenitors. Materials methods investigated cellular processes controlled by T2ECs...
Purpose: The Scedosporium apiospermum species complex usually ranks second among the filamentous fungi colonizing airways of patients with cystic fibrosis (CF), but little is known about molecular epidemiology airway colonization. Methods: Polymerase chain reaction (PCR) amplification repetitive sequences (rep-PCR) was applied to retrospective analysis a panel isolates already studied by random polymorphic DNA (RAPD) and comprising 63 recovered from sputa 9 CF patients. Results were compared...
Epidemiology of fungaemia and fungal meningitis in Sweden : a nationwide retrospective observational survey from sept 2015-aug 2016
Scedosporium species are usually soil saprophytes but some members of the genus such as S. apiospermum and aurantiacum have been regularly reported causing human respiratory infections, particularly in patients with cystic fibrosis (CF). Because their low sensitivity to almost all available antifungal drugs, a better understanding pathogenic mechanisms these fungi is mandatory. Likewise, identification origin contamination CF may be helpful propose prophylactic measures. In this aim,...