A5038118825- Neural dynamics and brain function
- EEG and Brain-Computer Interfaces
- Neuroscience and Neural Engineering
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Neuroscience and Neuropharmacology Research
- Anesthesia and Sedative Agents
- Advanced MRI Techniques and Applications
- Photoreceptor and optogenetics research
- Sleep and Wakefulness Research
- Lipid Membrane Structure and Behavior
- Ion channel regulation and function
- Dementia and Cognitive Impairment Research
- Hemodynamic Monitoring and Therapy
- Nicotinic Acetylcholine Receptors Study
- Animal Vocal Communication and Behavior
- MRI in cancer diagnosis
- Sleep and related disorders
- Radiomics and Machine Learning in Medical Imaging
- Cholinesterase and Neurodegenerative Diseases
- Quantum and Classical Electrodynamics
- Cellular transport and secretion
- bioluminescence and chemiluminescence research
- Quantum Information and Cryptography
- Circadian rhythm and melatonin
Cognizant (United States)
2020-2023
Boston University
2014
Harvard University
2010-2014
Pain and Rehabilitation Medicine
2013
Massachusetts General Hospital
2009-2011
National Postdoctoral Association
2011
Northwestern University
2011
Williams & Associates
2011
Massachusetts Institute of Technology
2010
Columbia University
2001-2007
Unconsciousness is a fundamental component of general anesthesia (GA), but anesthesiologists have no reliable ways to be certain that patient unconscious. To develop EEG signatures track loss and recovery consciousness under GA, we recorded high-density EEGs in humans during gradual induction emergence from unconsciousness with propofol. The subjects executed an auditory task at 4-s intervals consisting interleaved verbal click stimuli identify consciousness. During induction, lost...
Recent data reveal that the general anesthetic propofol gives rise to a frontal α-rhythm at dose levels sufficient induce loss of consciousness. In this work, computational model is developed suggests network mechanisms responsible for such rhythm. It shown can alter dynamics in thalamocortical loops, leading persistent and synchronous α-activity. The synchrony forms cortex by virtue involvement thalamus may impede responsiveness external stimuli, thus providing correlate unconscious state.
Time and frequency domain analyses of scalp EEG recordings are widely used to track changes in brain states under general anesthesia. Although these have suggested that different spatial patterns associated with the state anesthesia, extent which spatially coordinated has not been systematically characterized. Global coherence, ratio largest eigenvalue sum eigenvalues cross-spectral matrix at a given time, analyze spatiotemporal dynamics multivariate time-series. Using 64-lead recorded from...
Although accumulating evidence suggests that arousal pathways in the brain play important roles emergence from general anesthesia, of monoaminergic circuits are unclear. In this study, authors tested hypothesis methylphenidate (an inhibitor dopamine and norepinephrine transporters) induces isoflurane anesthesia.Using adult rats, effect intravenous on time to anesthesia. They then performed experiments test separately for methylphenidate-induced changes minute ventilation. A dose-response...
Pathological proteins contributing to Alzheimer’s disease (AD) are known disrupt normal neuronal functions in the brain, leading unbalanced excitatory-inhibitory tone, distorted synchrony, and network oscillations. However, it has been proposed that abnormalities activity directly contribute pathogenesis of disease, fact demonstrated induction synchronized 40 Hz gamma oscillation networks by sensory stimulation reverses AD-related pathological markers transgenic mice carrying human genes....
Patients with Alzheimer's disease (AD) demonstrate progressive white matter atrophy and myelin loss. Restoring content or preventing demyelination has been suggested as a therapeutic approach for AD.
Accurate quantification of loss response to external stimuli is essential for understanding the mechanisms consciousness under general anesthesia. We present a new approach quantifying three possible outcomes that are encountered in behavioral experiments during anesthesia: correct responses, incorrect responses and no response. use state-space model with two state variables representing probability conditional show applications this an example auditory at varying levels propofol anesthesia...
To evaluate the safety, tolerability, adherence, and efficacy of 40Hz sensory stimulation therapy in subjects with Alzheimer's disease (AD).
We examine the effects of short-term synaptic depression on orientation tuning LGN input to simple cells in cat primary visual cortex (V1). The total has an untuned component as well a tuned component, both which grow with stimulus contrast. is not visible firing rate responses cells. suppression contribution key establishing selectivity and its invariance It been argued that inputs could contribute selective thus observed this using model fit at thalamocortical synapses in-vivo, compare...
General anesthesia is currently defined in the context of its use clinical care [1]. The mechanism by which anesthetic drugs induce general not well understood. There therefore a need to incorporate neurophysiological characterizations into definition and understanding anesthesia. Distinct patterns electroencephalogram have been associated with anesthesia-induced loss consciousness [2-4] are used as part protocols monitor integrity brain function [5]. However, transition unconsciousness...
Proper functioning of the nervous system requires precise control neurotransmitter release. Synaptotagmin, a synaptic vesicle protein, is crucial for temporal The mechanism synaptotagmin function still under debate. To investigate by which controls release, we injected an antibody rat I into crayfish motor axon. We found that enhanced transmission at neuromuscular junctions increasing amplitude evoked response. This effect was antibody-dose dependent. also reduced rise time potentials. These...
Objective To examine the impact of 40Hz gamma stimulation on preservation corpus callosum, a critical structure for interhemispheric connectivity, in people with mild cognitive impairment or Alzheimer's disease. Methods OVERTURE (NCT03556280) participants were randomized 2:1 (Active:Sham) to receive daily, 1-h, sensory sham treatment 6 months. Structural magnetic resonance imaging data analyzed assess changes callosum area ( N = 50; 33 active, 17 sham). Bayesian linear mixed-effects modeling...
Abstract Background Recent research by Da et al. (2023) has demonstrated that non‐invasive gamma sensory stimulation can reduce brain white matter atrophy and myelin content loss. The impact on the Corpus Callosum (CC), brain's largest commissural tract essential for hemispheric connectivity, remains unexplored. Diffusion Tensor Imaging (DTI) studies (Delvenne 2023), have identified variations alterations in CC's bundles Alzheimer's disease (AD). We conducted an analysis of CC changes...
Abstract Background The OVERTURE (NCT03556280) randomized controlled trial (RCT) evaluated evoked gamma oscillation therapy using Cognito’s medical device (CogTx‐001) in mild‐moderate Alzheimer’s disease (AD). Brain atrophy, as measured by whole brain volume (WBV), is a key indicator of neurodegeneration AD 1 and may be influenced baseline covariates such age 2 , stage 3 APOE4 carrier status 4 PET amyloid levels 5 well treatment 6 . We analyzed MRI outcomes across these subgroups. Method...
The speed and reliability of neuronal reactions are important factors for proper functioning the nervous system. To understand how organisms use protein molecules to carry out very fast biological actions, we quantified single-molecule reaction time its variability in synaptic transmission. From delay crayfish neuromuscular synapses a few Ca(2+) ions bind with their sensors evoked neurotransmitter release was estimated. In standard saline at room temperature, average binding 0.12 ms first...
Abstract Background Non‐invasive, visual and auditory gamma (40 Hz) sensory stimulation demonstrates clearance of β‐amyloid plaques tau tangles, cognition improvement in preclinical AD models (Iaccarino, 2016, Martorell, 2019). A home‐use device (Cognito Therapeutics, Inc., Cambridge, MA) was developed to evoke oscillations humans. The long‐term safety feasibility this approach has not been previously evaluated subjects. Method Overture is a prospective 6‐month treatment study...
Abstract Background As a potential neurophysiology‐based biomarker of cortical neuronal network integrity, visually evoked steady‐state oscillations (SSVEPs) are investigated in healthy young and elderly subjects, mild cognitive impaired (MCI) Alzheimer’s disease (AD) patients. Based on recent findings from the Li‐Huei Tsai Laboratory (Picower Institute, MIT) showing that 40 Hz audio/visual stimulation reverses AD‐related pathologies transgenic mice, we evaluating effects brain...
Abstract Background Alzheimer’s disease (AD) patients exhibit distorted excitatory‐inhibitory balance of neuronal activity, leading to accelerated worsening functional and cognitive abilities. Improving abnormal synchrony by long‐term non‐invasive, gamma sensory stimulation at 40 Hz in transgenic mice carrying pathological AD human genes has been shown beneficially affect neural activity improve learning memory. In the present translational clinical trial, effects on cognition global...
Abstract Background Previous work has shown that sleep abnormalities are associated with Alzheimer’s Disease (AD) in multiple ways, including the observation disruptions precede onset of cognitive symptoms AD subjects, and there is a strong association between disrupted development progression (Ju et al, Nat Rev Neurol. 2014 Feb; 10(2): 115‐119, Lim Neurodegener Dis Manag. 2014; 4(5):351‐362). These associations, along fact disturbances can have broad behavioral effects, led to suggestion...
This study of anesthetic malpractice claims found that autopsy findings are more often helpful than harmful in the defense anesthesia care.Autopsies should be encouraged for unexpected deaths or death with ambiguous causes.