A5012494344- Adipose Tissue and Metabolism
- Neurogenesis and neuroplasticity mechanisms
- Neuroscience and Neuropharmacology Research
- Sirtuins and Resveratrol in Medicine
- Exercise and Physiological Responses
- Cancer, Hypoxia, and Metabolism
- Endoplasmic Reticulum Stress and Disease
- Anesthesia and Neurotoxicity Research
- Mesenchymal stem cell research
- High Altitude and Hypoxia
- Diet and metabolism studies
- Spine and Intervertebral Disc Pathology
- Musculoskeletal pain and rehabilitation
- Neuroinflammation and Neurodegeneration Mechanisms
- Mitochondrial Function and Pathology
- Neurological Disease Mechanisms and Treatments
- Stress Responses and Cortisol
- Estrogen and related hormone effects
- Apelin-related biomedical research
- Hormonal Regulation and Hypertension
- Menopause: Health Impacts and Treatments
- Neurological Disorders and Treatments
- Biochemical effects in animals
- Autophagy in Disease and Therapy
- Circadian rhythm and melatonin
Shanghai University of Sport
2016-2025
Second Military Medical University
1998-2003
The initiation and progression of neurodegenerative diseases (NDs), distinguished by compromised nervous system integrity, profoundly disrupt the quality life patients, concurrently exerting a considerable strain on both economy social healthcare infrastructure. Exercise has demonstrated its potential as an effective preventive intervention rehabilitation approach among emerging therapeutics targeting NDs. As largest secretory organ, skeletal muscle possesses capacity to secrete myokines,...
We investigated the effects of aerobic exercise on expression hippocampal synaptic plasticity-associated proteins in rats with type 2 diabetes and their possible mechanisms. A rat model was established 8 weeks high-fat diet combined a single intraperitoneal injection streptozotocin (STZ). Then, 4-week intervention conducted. Memory performance measured Y maze tests. The activity involved PI3K/Akt/mTOR, AMPK/Sirt1, NF κ B/NLRP3/IL-1 β signaling pathways were evaluated by western blot. Our...
High-intensity interval training (HIIT) is reported to be beneficial brain-derived neurotrophic factor (BDNF) biosynthesis. A key element in this may the existence of lactate, most obvious metabolic product exercise. In vivo , study investigated effects a 6-week HIIT on peripheral and central lactate changes, mitochondrial quality control system, function BDNF expression mouse hippocampus. vitro primary cultured mice hippocampal cells were used investigate role underlying mechanisms...
To explore the effects of methane-rich saline (CH4 saline) on capability one-time exhaustive exercise in male SD rats.Thirty rats were equally divided into to three groups at random: control group (C), placebo (P) and methane (M). Rats M underwent intraperitoneal injection CH4 saline, other two simultaneously normal saline. Then, was tested through treadmill except C group. Exercise time body weight recorded before after exercise. After exercise, blood gastrocnemius samples collected from...
Purpose To investigate the effects of hypoxic conditioned media from rat cerebral cortical cells on proliferation and differentiation neural stem (NSCs) in vitro, to study roles PI3-K/Akt JNK signal transduction pathways these processes. Methods Cerebral neonatal Sprague–Dawley were cultured under normoxic conditions; supernatant was collected named 'hypoxic medium' (HCM) 'normoxic (NCM), respectively. We detected protein levels (by ELISA) VEGF BDNF mRNA RT-PCR) cells. The (number size...
Lipotoxicity of palmitic acid (PA) or high-fat diets has been reported to increase endoplasmic reticulum (ER) stress and autophagy in peripheral tissue as well apoptotic cell death. It also can lead an AD-like pathological pattern. However, it unknown that PA-induced ER are involved the regulation neuroplastic abnormalities. Here, we investigated roles apoptosis neuroplasticity-related protein expression PA-treated prefrontal cells. Prefrontal cells dissected from newborn Sprague-Dawley rats...
BACKGROUND The cognitive impact of estradiol (E2), a sex steroid hormone, particularly its unique characteristics mediated through different estrogen receptors (ERs), is garnering research interest to optimize replacement therapy (ERT) and mitigate adverse effects. However, systematic bibliometric investigation elucidating the connection between E2/ERs cognition lacking. This study examines 3502 Web Science Core Collection publications using CiteSpace unveil trends in this field. MATERIAL...
To investigate the effects of supplement corn peptides plus aerobic exercise on fat loss and blood lipid profile in obese rats resulted from high diet mechanism:the role adipose triglyceride lipase (ATGL) lipoprotein (LPL).One hundred fifty male SD (4 weeks age) were randomly divided into control group (C, n=15) fed with ordinary model (M, n=135) for 8 weeks. Forty whose body weight increased by 20% mean value con-trol selected 5 groups(n=8):obesity group, casein exercise+corn group. The...