A5044414106- Ocular Diseases and Behçet’s Syndrome
- Avian ecology and behavior
- Adipose Tissue and Metabolism
- Physiological and biochemical adaptations
- Species Distribution and Climate Change
- Bat Biology and Ecology Studies
- Animal Behavior and Reproduction
- Infectious Diseases and Tuberculosis
- Retinal and Optic Conditions
- Animal Nutrition and Physiology
- Epigenetics and DNA Methylation
- Retinal Diseases and Treatments
- Birth, Development, and Health
- Systemic Lupus Erythematosus Research
- Genetics, Aging, and Longevity in Model Organisms
- Autoimmune and Inflammatory Disorders
- Neuroendocrine regulation and behavior
- Isotope Analysis in Ecology
- Fish Ecology and Management Studies
- Sinusitis and nasal conditions
- Ocular Infections and Treatments
- Plant and animal studies
- Animal Ecology and Behavior Studies
- Bartonella species infections research
- Dermatological diseases and infestations
University of Chile
2010-2025
Pontificia Universidad Católica de Chile
2005-2023
Center of Applied Ecology & Sustainability
2021-2023
Clínica Las Condes
2019-2020
Hospital del Salvador
2010-2019
Developmental effects of exposure to endocrine disruptors can influence adult characters in mammals, but could also have evolutionary consequences. The aim this study was simulate an environmental experimental population mice high amounts nutritional phytoestrogens and evaluate parameters relevance for change the offspring. effect a continuous pre- post-natal levels dietary isoflavones evaluated on sexual maturity, morphometric DNA methylation status mice. Adult male/female couples were fed...
Abstract Purpose To evaluate clinical outcomes of first‐line immunomodulatory therapy ( IMT ) and prednisone alone or late in V ogt‐ K oyanagi‐ H arada disease. Methods Retrospective cohort study 152 patients with disease evaluated a referral uveitis clinic C hile from 1985 to 2011. Medical records these were reviewed. Demographic data, evaluation, type treatment, functional outcomes, glucocorticoid GC dose complications recorded. Multivariate logistic regression was used identify prognostic...
Lactation is the most energetically demanding period in life cycle of female mammals, and its effects on digestive flexibility size internal organs have been extensively studied laboratory mice rats since early 1900s. However, there only two studies this topic for wild rodent species. Here, we analyzed flexibility--that is, changes gut content, activity enzymes, morphology--during lactation caviomorph Octodon degus. In addition, evaluated other their relationship with resting metabolic rate....
Animal personalities are interindividual behavioral differences that consistent across time or contexts. Increasing research is revealing the adaptive significance of personalities, although mechanisms driving this variation remain largely unknown. A possible source in personality traits interpopulational strength selection acting upon them. The response to can be measured indirectly via behavior's repeatability, as repeatability generally sets an upper limit trait heritability. However, no...
Abstract To cope with life in the mountains, populations of same species can exhibit substantial variability their altitudinal migration patterns and phenotypes response to local weather conditions. Studying such provide valuable insights into how respond environmental challenges, this information be useful for conservation efforts mountain ecosystems. Here, we used δ 2 H values feathers blood evaluate latitudinal variation its possible links body size, oxidative status, exploratory behavior...
Increasing research has attempted to clarify the links between animal personality and physiology. However, mechanisms driving this association remain largely unknown, knowledge of how ecological factors may affect its direction strength is scant. In study, we quantified variation in exploratory behavior, basal metabolic rate (BMR), total evaporative water loss (TEWL) rufous-collared sparrows (Zonotrichia capensis) inhabiting desert, Mediterranean, cold-temperate climates. We found that...
The climatic variability hypothesis (CVH) states that species are geographically more widespread at higher latitudes because individuals have a broader range of physiological tolerance or phenotypic flexibility as latitude and increase. However, it remains unclear to what extent latitude, acting on the phenotype, account for any observed geographical gradient in mean size. In this study, we analyzed within CVH framework by using an intraspecific population experimental approach. We tested...
Purpose: To characterize the clinical features in patients with presumed ocular tuberculosis (TB) and determine prognostic factors of visual outcomes complications this disease.Material methods: Retrospective case series 35 (29 females, 6 males) TB from referral centers Chile Spain between 2002 2012. Medical records were reviewed, data regarding features, complications, best-corrected acuity (BCVA), duration disease, extraocular manifestations, therapy retrieved. Prognostic for low vision...
Parinaud's oculo-glandular syndrome (POGS) is the most frequent manifestation of ocular bartonellosis, and usually presents with local lymphadenopathies systemic symptoms. We present a case isolated conjunctival granuloma as sole bartonellosis.A 67-year-old female presented to authors' eye clinic complaints 2-week history unilateral red chemosis. Slit lamp examination revealed an bulbar granuloma. The remainder was unremarkable. Topical treatment gatifloxacin prednisolone acetate started....
Purpose: To determine the performance of T-SPOT.TB, an interferon gamma release assay test, in patients with ocular tuberculosis (TB) a BCG-vaccinated, non-endemic population.Methods: We employed nested case–control design. In total, 45 subjects were enrolled (23 and 22 other causes uveitis). A blood sample was collected from each subject, T-SPOT.TB executed. Laboratory professionals blinded to disease status subject.Results: Five excluded because indeterminate results. The calculated...
Abstract In order to maintain the energy balance, animals often exhibit several physiological adjustments when subjected a decrease in resource availability. Specifically, some rodents show increases behavioral activity response food restriction; regarded as paradox because it would imply an investment locomotor activity, despite lack of trophic resources. Here, we aim explore possible existence trade-offs between metabolic variables and responses are faced stochastic deprivation caloric...
Tracing how free-ranging organisms interact with their environment to maintain water balance is a difficult topic study for logistical and methodological reasons. We use novel combination of triple-oxygen stable isotope analyses extracted from plasma (δ 16 O, δ 17 18 O) bulk tissue carbon 13 C) nitrogen 15 N) isotopes feathers blood estimate the proportional contribution marine resources, seawater, metabolic used by two species unique songbirds (genus Cinclodes ) in seasonal coastal...
Purpose To describe clinical features of patients with diabetes mellitus-associated uveitis (DMAU).Methods Retrospective analysis records and mellitus (DM) presented in an referral centre Chile.Demographic data, comorbidities, complete ophthalmic examination, treatments were analyzed.Results We found 72 DM: 16 DMAU poorly regulated DM (22%), 15 well-controlled (21%), 41 due to established other causes than (57%).Patients diabetes, inflammation 3–4+ cells 33%, a fibrinous reaction 28%,...
Understanding physiological traits and ecological conditions that influence a species reliance on metabolic water is critical to creating accurate models can assess their ability adapt environmental perturbations (e.g., drought) impact availability. However, relatively few studies have examined variation in the sources of animals use maintain balance, even fewer focused role water. A key reason methodological limitations. Here, we applied new method measures triple oxygen isotopic...
We studied the putative effect of early experience on physiological flexibility metabolic and osmoregulatory traits in leaf-eared mouse Phyllotis darwini, an altricial rodent inhabiting seasonal mediterranean environments. Adult individuals were collected central Chile maintained breeding pairs. Pups isolated after weaning acclimated to different temperature (cold or warm) water availability (unrestricted restricted) until adulthood. Subsequently, re-acclimated opposite treatment. Rodents...
La Enfermedad Inflamatoria Intestinal (EII) se considera una enfermedad sistémica por su alta prevalencia de manifestaciones en otros órganos. Hasta el 50% los pacientes pueden llegar a tener compromiso extraintestinal, principalmente articulaciones, piel y ojos, causando un significativo deterioro la calidad vida. posibilidad algún extraintestinal aumenta mayor tiempo evolución enfermedad, aunque muchas veces estas no tienen relación con actividad inflamatoria intestino. El órganos puede...
Both the mean and variation in environmental temperature are increasing globally. Indeed, predicted increases range from 2 to 4°C next 50 years. Ectotherms control body by means of behavior selecting microsites with different temperatures, which makes them more susceptible changes climate. Nevertheless, lizards living high mountain environments have developed several mechanisms inhabit colonize variable extreme temperatures. These include a metabolism be active at lower temperatures...
Variations in the availability of nutritional resources animals can trigger reversible adjustments, which short term are manifested as behavioral and physiological changes. Several these responses mediated by Sirt1, acts an energy status sensor governing a global genetic program to cope with changes status. Growing evidence suggests key role response perinatal environment caloric restriction setup adulthood. The existence adaptive predictive has been proposed, that early nutrition could...