A5018731729- Silicon Carbide Semiconductor Technologies
- Chemical Synthesis and Analysis
- Asymmetric Hydrogenation and Catalysis
- Oxidative Organic Chemistry Reactions
- Chemical Synthesis and Reactions
- Multilevel Inverters and Converters
- Advanced DC-DC Converters
- Induction Heating and Inverter Technology
- Electric Motor Design and Analysis
- Phenothiazines and Benzothiazines Synthesis and Activities
- Nanomaterials for catalytic reactions
- Coordination Chemistry and Organometallics
- Catalytic Cross-Coupling Reactions
- Asymmetric Synthesis and Catalysis
- Synthetic Organic Chemistry Methods
- Carbohydrate Chemistry and Synthesis
- Magnetic Properties and Applications
- Catalytic C–H Functionalization Methods
- Stock Market Forecasting Methods
- Immune cells in cancer
- Energy Load and Power Forecasting
- Synthesis of heterocyclic compounds
- Histone Deacetylase Inhibitors Research
- Carbon dioxide utilization in catalysis
- Advancements in Semiconductor Devices and Circuit Design
Shanghai Jiao Tong University
2020-2025
Shaoxing People's Hospital
2023
General Hospital of Shenyang Military Region
2023
Jiangsu University
2019-2020
Rutgers, The State University of New Jersey
2020
Tris Pharma (United States)
2012
Novartis (United States)
2001-2006
Novartis (Switzerland)
1999
University of Alabama
1992
Abstract Reduction of nitroarenes to anilines using activated iron generated by Fe/HCl or Zn/FeSO 4 is described. A variety functional groups such as alkyne, ketone, enone, nitrile, lactone, and aromatic halide are well tolerated under these conditions.
Silicon carbide (SiC) metal oxide semiconductor field-effect transistors (MOSFETs) are a future trend in traction inverters electric vehicles (EVs), and their thermal safety is crucial. Temperature-sensitive electrical parameters’ (TSEPs) indirect detection normally requires additional circuits, which can interfere with the system increase costs, thereby limiting applications. Therefore, there still lack of cost-effective sensorless monitoring techniques. This paper proposes high-efficiency...
Kilogram-scale syntheses of fragments C1-6 (6) and C9-14 (4) (+)-discodermolide from common precursor 3 are described. Improved procedures for each step both were developed by minimizing or eliminating the formation byproducts that isolated characterized in Smith's synthesis.
ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTThe First Enantioselective Synthesis of (2R,2'R)-threo-(+)-Methylphenidate HydrochlorideMahavir Prashad, Hong-Yong Kim, Yansong Lu, Yugang Liu, Denis Har, Oljan Repic, Thomas J. Blacklock, and Peter GiannousisView Author Information Process Research & Development, Chemical Analytical Novartis Institute for Biomedical Research, 59 Route 10, East Hanover, New Jersey 07936 Cite this: Org. Chem. 1999, 64, 5, 1750–1753Publication Date (Web):January 28,...
ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTβ-Hydrogen-Containing Sodium Alkoxides as Suitable Bases in Palladium-Catalyzed Aminations of Aryl HalidesMahavir Prashad, Bin Hu, Yansong Lu, Robert Draper, Denis Har, Oljan Repič, and Thomas J. BlacklockView Author Information Process Research & Development, Chemical Analytical Novartis Institute for Biomedical Research, 59 Route 10, East Hanover, New Jersey 07936 Cite this: Org. Chem. 2000, 65, 8, 2612–2614Publication Date (Web):March 29,...
Total syntheses of the cytotoxic marine natural products bengamides B and E are described. Both prepared via amide coupling a protected polyhydroxylated lactone intermediate 9 with suitably substituted aminocaprolactam intermediate. Lactone is in five steps from commercially available alpha-D-glucoheptonic gamma-lactone. The key reactions selective deprotection 1,2-acetonide presence 1,3-acetonide an (E)-selective olefination unstable aldehyde using gem-dichromium reagent. bengamide lactam...
To report a case of afatinib-induced toxic epidermal necrosis (TEN), in patient with metastatic non-small cell lung cancer (NSCLC) and compare these findings that evaluate similarities differences to other cases reported the literature. With use algorithm drug causality for necrolysis (ALDEN), effects afatinib were evaluated NSCLC who developed TEN. In addition, previous reports on this topic included provide review patients' clinical characteristics, treatment regimens therapy outcomes...
Glioblastoma (GBM) is a primary malignant tumour with high intracranial morbidity, malignancy and poor prognosis. Abnormal changes in histone acetylation are closely related to the occurrence development of cancer. However, there still lack systematic research on GBM.Whole-transcriptome sequencing data clinical GBM patients were obtained through TCGA database. Single-cell RNA-sequencing (scRNA-seq) from GSE146711 Gene Expression Omnibus Cell descending fractionation was first performed for...
Di-isopropylphosphino-substituted pincer-ligated iridium catalysts are found to be significantly more effective for the dehydrogenation of simple tertiary amines give enamines than previously reported di-t-butylphosphino-substituted species. It is also that di-isopropylphosphino-substituted complexes catalyze several β-functionalized corresponding 1,2-difunctionalized olefins. The species ineffective such substrates; presumably, marked difference attributable lesser crowding catalysts....
Abstract An improved and practical procedure for the oxidation of primary alcohols to carboxylic acids under Sharpless's conditions (NaIO4/RuCl3.H2O/water/acetonitrile) using ethyl acetate as solvent, in place toxic ecologically undesirable carbon tetrachloride, is described.
An efficient synthesis of 9H-xanthene-9-carboxaldehyde (3a), 9H-thioxanthene-9-carboxaldehyde (3b), and 9,10-dihydro-10-methyl-9-acridinecarboxaldehyde (3c) by a novel two-carbon homologation xanthydrol (1a), thioxanthydrol (1b), 9,10-dihydro-10-methyl-9-acridinol (1c), respectively, using N-vinylacetamides (2a,b) or ethyl vinyl ether (2c) as acetaldehyde anion equivalents, is described.
The synthesis of C2 symmetric, optically active diols 6 and 7 from α-pinene is described. preparation involves the osmium tetroxide oxidation alkene 5, prepared in good yield by a McMurry coupling aldehyde 4.
Hotspots in traction motors of electric vehicles are normally considered to locate end windings due the loose packaging and no access iron cores for heat dissipation. To ensure safety, winding temperatures typically monitored by thermocouples thermal management systems real‐time cooling control. However, authors’ study finds that slot will exceed under high‐speed operations much higher additional loss caused alternating flux. Hence, thermocouple would underestimate actual peak temperature...
A linear 7-step synthesis of vildagliptin-β-O-glucuronide (2) starting from commercially available D-glucurono-6, 3-lactone (3) was herein achieved with 11.3% overall yield. Efficient preparation compound 6 in pure α form obtained, which proved critical to achieve high anomeric selectivity β-O-glycosylation later. The direct vildagliptin (1) containing both a tertiary alcohol and secondary amine studied good deprotection step afford product delicately executed avoid hydrolysis nitrile group....
Silicon carbide metal-oxide-semiconductor field-effect transistors (SiC MOSFETs) are widely used in high-performance power converters due to their superior switching characteristic. The increase of the speed improves efficiency system, whereas this also brings undesirable problems, such as voltage spikes and crosstalks. Most existing gate driver methods cannot flexibly regulate device speeds match system requirements. To facilitate devices operating desired state, paper proposes a...
Monitoring the critical temperature of stator windings and power semiconductors is crucial for thermal safety electric vehicles. Embedding sensors most common monitoring method used in industry, yet are constrained by their lifetime. Temperature-sensitive electrical parameters (TSEPs) detection a promising characterization approach to condition single target. However, due parameter coupling, there still lack cost-effective strategies with homogenous multi-components. And TSEPs limited...
Abstract magnified image Lithiation of N ‐protected‐2,3‐dihydro‐1,4‐benzoxazines is described. ‐( tert ‐butoxycarbonyl)‐2,3‐dihydro‐1,4‐benzoxazine ( 1 ) with BuLi/TMEDA occurred in the α‐position to nitrogen on heterocyclic ring, leading unexpected ring‐opened product 3 . On other hand, lithiation ‐methyl‐2,3‐dihydro‐1,4‐benzoxazine 4 took place at oxygen‐adjacent ortho ‐position aromatic ring.
For ensuring the electric motor safety of vehicles (EVs), temperature sensors are embedded in stator windings for diagnosis and monitoring, but constrained by their lifetime vulnerability. To solve this issue, a sensorless initial estimation method winding is proposed. The innovation lies that based on combination thermal models traction inverter. Through sequential current pulse injection, electrical characteristics system circuit were extracted state was identified according to designed...
The phase current of the permanent magnet synchronous motors (PMSM) commonly contains nonnegligible sideband harmonics due to working characteristic and pulse-width-modulation (PWM) power electronics for supply, especially at high speed operation. These will degenerate output performance machine, generate additional losses, threaten thermal safety. Therefore, are eager be accurately obtained analyzed in real-time achieve better status monitoring diagnosis. This paper proposes a high-accuracy...
With the development of electrified aircraft research, operation power converters at cryogenic temperature is increasing. Developing an effective method to analyze performance SiC MOSFET (Metal Oxide Semiconductor Field Effect Transistor) temperatures crucial. However, existing data sheets can only provide curves around -50°C, and more tedious tests are required obtain parameters lower temperatures. This paper proposes a physics-based compact model MOSFETs which directly predict temperature....