A5101490183- Superconducting Materials and Applications
- Particle accelerators and beam dynamics
- Particle Accelerators and Free-Electron Lasers
- Spacecraft and Cryogenic Technologies
- Physics of Superconductivity and Magnetism
- Muon and positron interactions and applications
- Advanced Thermodynamic Systems and Engines
- Superconductivity in MgB2 and Alloys
- Particle physics theoretical and experimental studies
- Particle Detector Development and Performance
- Magnetic confinement fusion research
- Frequency Control in Power Systems
- Refrigeration and Air Conditioning Technologies
- Heat Transfer and Optimization
- Neutrino Physics Research
- Peptidase Inhibition and Analysis
- Methane Hydrates and Related Phenomena
- Heat Transfer and Numerical Methods
- Pluripotent Stem Cells Research
- Protein Degradation and Inhibitors
- CRISPR and Genetic Engineering
- Advanced X-ray Imaging Techniques
- HVDC Systems and Fault Protection
- Histone Deacetylase Inhibitors Research
- Ubiquitin and proteasome pathways
University of Washington
2024
Lawrence Berkeley National Laboratory
2011-2023
Michigan State University
2015-2017
Oregon State University
2016
City University of New York
2016
City College
2016
City College of New York
2016
Lexicon Pharmaceuticals (United States)
2014
University of Kentucky
1989-2010
Markey Cancer Center
2009
Magnetic resonance elastography (MRE) is a non-invasive imaging technique used to visualise and quantify mechanical properties of tissue, providing information beyond what can be currently achieved with standard MR sequences could, for instance, provide new insight into pathological processes in the brain. This study uses MRE at 3 T extract complex shear modulus vivo brain tissue utilizing full three-dimensional approach reconstruction, removing contributions dilatational wave by application...
The status of the research on muon colliders is discussed and plans are outlined for future theoretical experimental studies. Besides continued work parameters a 3-4 0.5 TeV center-of-mass (CoM) energy collider, many studies now concentrating machine near 0.1 that could be factory s-channel production Higgs particles. We discuss various components in such colliders, starting from proton accelerator needed to generate pions heavy-Z target proceeding through phase rotation decay ($\pi \to \mu...
We describe the status of our effort to realize a first neutrino factory and progress made in understanding problems associated with collection cooling muons towards that end. summarize physics can be done factories as well intense cold beams muons. The potential muon colliders is reviewed, both Higgs Factories compact high energy lepton colliders. timescale research development reviewed latest designs channels including promise ring coolers achieving longitudinal transverse simultaneously....
A series of N-hydroxy-3-phenyl-2-propenamides were prepared as novel inhibitors human histone deacetylase (HDAC). These compounds potent enzyme inhibitors, having IC(50)s < 400 nM in a partially purified assay. However, potency cell growth inhibition assays ranged over 2 orders magnitude two carcinoma lines. Selected cellular IC(50) 750 tested for maximum tolerated dose (MTD) and efficacy the HCT116 colon tumor xenograft Four an MTD > or = 100 mg/kg selected dose-response studies model. One...
The elk prion protein gene (PRNP) encodes either methionine (M) or leucine (L) at codon 132, the L132 allele apparently affording protection against chronic wasting disease (CWD). corresponding human 129 polymorphism influences host range of bovine spongiform encephalopathy (BSE) prions. To fully address influence this cervid on CWD pathogenesis, we created transgenic (Tg) mice expressing PrPC with L residue referred to as CerPrPC-L132, and compared transmissibility prions from defined PRNP...
Inhibitors of histone deacetylase (HDAC) have been shown to induce terminal differentiation human tumor cell lines and antitumor effects in vivo. We prepared analogues suberoylanilide hydroxamic acid (SAHA) trichostatin A evaluated them a HDAC enzyme inhibition assay, p21waf1 (p21) promoter monolayer growth assays. One compound, 4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]-benzamide, was found affect the panel eight differentially.
We describe a novel device that can be used for the transcervical transfer of embryos into pseudopregnant female mice. This nonsurgical embryo (NSET) is as efficient standard surgical in production transgenic mice, and also embryonic stem cell-containing chimeric blastocysts cryopreserved embryos. In addition to elimination surgery, recipient females do not have anesthetized. The NSET eliminates painful procedure well potential complications associated with anesthesia/post-operative care,...
This paper discusses the magnetic measurements of residual field in superconducting dipole and quadrupole magnets. The technique used to measure fields is described herein. results measurement are presented compared with a simplified theory, which predicts basic nature fields. theory experiment agree reasonably well despite simplifying assumptions made theory. generated magnet do affect uniformity such magnet. effects worst at low field, precisely where one wants most synchrotron. suggests...
Total syntheses of the cytotoxic marine natural products bengamides B and E are described. Both prepared via amide coupling a protected polyhydroxylated lactone intermediate 9 with suitably substituted aminocaprolactam intermediate. Lactone is in five steps from commercially available alpha-D-glucoheptonic gamma-lactone. The key reactions selective deprotection 1,2-acetonide presence 1,3-acetonide an (E)-selective olefination unstable aldehyde using gem-dichromium reagent. bengamide lactam...
A perfect varistor is a constant voltage resistor as function of current through the resistor. can't exist, because its resistance would be infinite at zero current. In electronic devices, varistors are often used surge protectors. can in place an ordinary discharge across superconducting coil sections. When this way, integral I <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> dt during reduced by almost one third. for quench protection...
The order of the toxicity proteins investigated is as follows: protamine > histone globin. Globin was found to be devoid appreciable when injected into animals or tested on tissues and monocellular organisms in vitro. Protamine were highly toxic trypanosomes. Factors which may contribute these discussed.
The purpose of the MICE spectrometer solenoid is to provide a uniform field for scintillating fiber tracker. produced by long center coil and two short end coils. Together, they produce 4T with uniformity better than 1% over detector region 1000 mm 300 in diameter. Throughout most region, 0.3%. In addition coils, we have match These coils can be independently adjusted focusing field. package length 2544 mm. We present cold mass design, powering quench protection circuits, cryogenic cooling...
The need for cryogenic cooling has been a critical issue that kept superconducting electronic devices from reaching the market place. Even though performance of many circuits is superior to silicon electronics, requirement put at serious disadvantage. This paper discusses process refrigerating with liquids and small cryocoolers. Three types cryocoolers are compared vibration, efficiency reliability. connection cryocooler load discussed. A comparison using flexible copper straps carry heat...
Quench protection is the elephant in room, when it comes to high temperature superconducting (HTS) magnets. For many HTS magnets, quench has not been much of a problem, because stored energies magnets have low compared The principles are same regardless type superconductor used. In general, problem if adiabatic hot spot at end less than that damages conductor or its insulation and magnet voltages enough breach insulation. It long understood propagation along an slower for Nb-Ti. reason this...
The Muon Ionization Cooling Experiment (MICE) will demonstrate ionization cooling in a short section of realistic channel using muon beam at Rutherford Appleton Laboratory the UK. coupling magnet is superconducting solenoid mounted around four 201 MHz RF cavities, which produces magnetic field up to 2.6 T on centerline keep muons within iris cavities windows. coil with inner radius 750 mm, length 285 mm and thickness 102.5 be cooled by pair 1.5 W 4.2 K small coolers. This paper introduce...
The cyclotron gas-stopper magnet (CGSM) at Michigan State University (MSU) was used as model for a study whether HTS conductor is feasible use in cyclotrons. outside diameter of the CGSM split warm iron yoke 4 m, with pole radius 1.1 m. desired field shape obtained by shaping profile. Each superconducting coil separate cryostat. two coils are connected series through electrical connection. wound and potted within an 80 mm × cross section mounted 304 stainless steel helium vessel that...
This report describes the MICE spectrometer solenoids as built. Each magnet consists of five superconducting coils. Two coils are used to tune beam going from or rest cooling channel. Three (two end and a long center coil) create uniform 4 T field (to plusmn0.3 percent) over length 1.0 m within diameter 0.3 m. The three-coil set is connected in series. two use small power supplies region where scintillating fiber tracker located. paper will present results preliminary testing first solenoid.
A number of papers have been written suggesting that superconducting magnets could be cooled by using supercritical helium (helium at pressures above the critical pressure 2.2 atm). Nearly all schemes for involve circulating inside fully stabilized hollow superconductors. This paper describes a helium-cooled magnet which is quite different. magnet, built LRL, utilizes an intrinsically stable, low-ac-loss superconductor. The heat generated with coil conducted to cooling tubes are adjacent...
The Michigan State University cyclotron gas-stopper magnet generates a strong focusing magnetic field that permits an ion beam of up to 100 MeV/u enter the and have most its energy reduced by low-pressure helium gas. has two superconducting coil cryostats mounted within warm iron poles split return yoke. coils are connected in series using room temperature cables. peak stored is 3.5 MJ. been tested full operating current 180 A. During tests, discharged inadvertently three times. Two...