A5030270407- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Malaria Research and Control
- Viral Infections and Outbreaks Research
- Metaheuristic Optimization Algorithms Research
- Evolutionary Algorithms and Applications
- Insect symbiosis and bacterial influences
- Vector-Borne Animal Diseases
- SARS-CoV-2 and COVID-19 Research
- Vector-borne infectious diseases
- Bacillus and Francisella bacterial research
- Vibrio bacteria research studies
- Bacterial Genetics and Biotechnology
- Plant Virus Research Studies
- Hepatitis B Virus Studies
- interferon and immune responses
- Influenza Virus Research Studies
- Virology and Viral Diseases
- Viral gastroenteritis research and epidemiology
- Advanced Multi-Objective Optimization Algorithms
- Zoonotic diseases and public health
- Vaccine Coverage and Hesitancy
- Infectious Encephalopathies and Encephalitis
- vaccines and immunoinformatics approaches
- Phosphodiesterase function and regulation
The University of Texas Medical Branch at Galveston
2015-2025
Human BioMolecular Research Institute
2023
Morriston Hospital
2021
Collegium Carolinum
2020
Bob Jones University
2020
Clinical Research Services
2001-2014
Bipar
2009
Institute of Infection and Immunity
2009
The University of Texas at Austin
2009
Galveston College
2003-2007
A technique is described that allows unimodal function optimization methods to be extended locate all optima of multimodal problems efficiently. We describe an algorithm based on a traditional genetic (GA). This involves iterating the GA but uses knowledge gained during one iteration avoid re-searching, subsequent iterations, regions problem space where solutions have already been found. gain achieved by applying fitness derating raw function, so values are depressed in Consequently,...
Abstract Dengue is a major health threat and the number of symptomatic infections caused by four dengue serotypes estimated to be 96 million 1 with annually around 10,000 deaths 2 . However, no antiviral drugs are available for treatment or prophylaxis dengue. We recently described interaction between non-structural proteins NS3 NS4B as promising target development pan-serotype virus (DENV) inhibitors 3 Here we present JNJ-1802—a highly potent DENV inhibitor that blocks NS3–NS4B within viral...
The introduction of West Nile virus (WNV) into North America has been associated with relatively high rates neurological disease and death in humans, birds, horses, some other animals. Previous studies identified strains both genetic lineage 1 2, including American isolates 1, that were highly virulent a mouse neuroinvasion model, while avirulent or significantly attenuated (D. W. C. Beasley, L. Li, M. T. Suderman, A. D. Barrett, Virology 296:17-23, 2002). To begin to elucidate the basis for...
Using a panel of neutralizing monoclonal antibodies, we have mapped epitopes in domain III the envelope protein New York strain West Nile virus. The ability antibodies that recognize these to neutralize virus appeared differ between lineage I and II strains, were located on upper surface at residues E307, E330, E332.
West Nile virus (WNV) RNA was demonstrated in 5 (20%) of 25 urine samples collected from convalescent patients 573-2452 days (1.6-6.7 years) after WNV infection. Four the amplicons sequenced showed >99% homology to NY99 strain. These findings show that individuals with chronic symptoms infection may have persistent renal over several years.
Abstract West Nile virus (WNV) antibodies were detected in horses from five Mexican states, and WNV was isolated a Common Raven the state of Tabasco. Phylogenetic studies indicate that this isolate, first Mexico, is related to strains central United States but has relatively high degree sequence divergence.
The solution structure of domain III from the New York West Nile virus strain 385-99 (WN-rED3) has been determined by NMR methods. is a β-barrel formed seven anti-parallel β-strands in two β-sheets. One β-sheet consists β1 (Phe299-Asp307), β2 (Val313-Tyr319), β4 (Arg354-Leu355), and β5 (Lys370-Glu376) arranged so that flanked on either side β5. short flanks end remaining strands β3 (Ile340-Val343), β6 (Gly380-Arg388), β7 (Gln391-Lys399) with at center. Residues implicated antigenic...
Since the 1990s West Nile virus (WNV) has become an increasingly important public health problem and cause of outbreaks neurological disease. Genetic analyses have identified multiple lineages with many studies focusing on lineage 1 due to its emergence in New York 1999 neuroinvasive phenotype. Until recently, viruses 2 were not thought be importance few disease being associated this lineage. However, recent epidemics Europe (Greece Italy) Russia shown increasing There are very genetic...
Chikungunya virus (CHIKV) is an arthritogenic alphavirus that during the last decade has significantly expanded its geographical range and caused large outbreaks of human disease around world. Although mortality rates associated with CHIKV are low, acute chronic illnesses by represent a significant burden largely affecting low middle income countries. This report summarizes current status vaccine development for CHIKV.
In December of 2013, chikungunya virus (CHIKV), an alphavirus in the family Togaviridae, was introduced to island Saint Martin Caribbean, resulting first autochthonous cases reported Americas. As January 2015, local and imported CHIKV has been 50 American countries with over 1.1 million suspected cases. causes a severe arthralgic disease for which there are no approved vaccines or therapeutics. Furthermore, lack commercially available, sensitive, affordable diagnostic assay limits...
Cross-neutralization is generally a prerequisite for cross-protection of vaccines against diseases caused by heterologous viruses. Using sera obtained from randomized clinical phase 3 trial in adults, we investigated the cross-neutralization activity VLA1553, vaccine recently approved to prevent chikungunya disease. Analysed plaque reduction neutralization test, three major virus (CHIKV) lineages, namely East Central South African, West and Asian lineage, were inhibited CHIKV-specific...