A5004918773- Asymmetric Hydrogenation and Catalysis
- Asymmetric Synthesis and Catalysis
- Nanomaterials for catalytic reactions
- Ionic liquids properties and applications
- Synthetic Organic Chemistry Methods
- Porphyrin and Phthalocyanine Chemistry
- Inorganic Fluorides and Related Compounds
- Organic Chemistry Cycloaddition Reactions
- Oxidative Organic Chemistry Reactions
- Fluorine in Organic Chemistry
- Chemical Synthesis and Reactions
- Synthesis and Catalytic Reactions
- Innovative Microfluidic and Catalytic Techniques Innovation
- Organoboron and organosilicon chemistry
- Axial and Atropisomeric Chirality Synthesis
- Carbohydrate Chemistry and Synthesis
- Ammonia Synthesis and Nitrogen Reduction
- Synthesis and Properties of Aromatic Compounds
- Photochromic and Fluorescence Chemistry
- Chemical Synthesis and Analysis
University of Bath
2024-2025
University of Milan
2020-2023
Mylan (South Africa)
2020
Abstract The ability to synthesise lemniscular molecules allow for the study and application of their chiroptical properties is a notable technical challenge. Herein, we report design synthesis enantiomers [5]helicenoid derived molecular lemniscate, in which two homochiral helicenes are linked via formation azine motifs. We demonstrate that these molecules, helicenoid constituents, also excellent chiral dopants induce dissymmetry ground excited states achiral emissive polymer F8BT, leading...
The catalytic enantioselective reduction of β,β-disubstituted nitroalkenes was performed in deep eutectic solvents, avoiding the use volatile organic compounds (VOCs) as reaction medium.The desired enantioenriched nitroalkanes were obtained high yields and enantiomeric excesses, up to 90%, by a metal-free, hydrogen bond-mediated methodology, with convenient experimental protocol that could be successfully applied gram-scale reaction.
A dearomative oxidation of pyrroles to Δ
Abstract A metal‐free, mild and chemodivergent transformation involving nitroalkanes has been developed. Under optimized reaction conditions, in the presence of trichlorosilane a tertiary amine, aliphatic were selectively converted into amines or nitriles. Furthermore, when chiral β‐substituted nitro compounds reacted, stereochemical integrity stereocenter was maintained α‐functionalized nitriles obtained with no loss enantiomeric excess. The methodology successfully applied to synthesis...
Deep eutectic solvents (DESs) have gained attention as green and safe well economically environmentally sustainable alternative to the traditional organic solvents. Here, we report combination of an atom-economic, very convenient inexpensive reagent, such BH 3 NH , with bio-based mixtures biorenewable in synthesis nitroalkanes, valuable precursors amines. A variety nitrostyrenes alkyl-substituted nitroalkenes, including α- β-substituted nitroolefins, were chemoselectively reduced atom...
Abstract A dearomative oxidation of pyrroles to Δ 3 ‐pyrrol‐2‐ones is described, which employs a sulfoxide as oxidant, in conjunction with carboxylic acid anhydride and Brønsted additive. 3‐substituted undergo regioselective give the product isomer oxygen has been introduced at more hindered position. Regioselectivity rationalized by proposed mechanism that proceeds initial thianthrenium introduction less‐hindered pyrrole α‐position, followed distal attack an nucleophile subsequent...
Abstract Ammonia borane (AB) has been successfully employed in the reduction of nitroalkenes. A variety nitrostyrenes and alkyl-substituted nitroalkenes were chemoselectively reduced to corresponding nitroalkanes, short reaction time, with an atom-economic, simple experimental procedure that also works α- β-substituted nitroolefins.
The development of new and efficient methods, reagents, catalysts for the introduction fluorine atoms or fluorinated moieties in molecular scaffolds has become a topic paramount importance organic synthesis. In this framework, incorporation SCF3 group into molecule often led to beneficial effects on drug’s metabolic stability bioavailability. Here we report our studies aimed stereoselective synthesis chiral α-SCF3-β−ketoesters featuring tetrasubstituted stereocenter. use auxiliary was...
Abstract δ‐nitro dienes were successfully synthesized and converted to alkenes with complete chemo regioselectivity. The enantioselective organocatalytic reduction was also accomplished afforded the product in up 97 % e.e. chiral nitro alkene further elaborated employed as starting material a stereoselective cyclization reaction that led an almost enantiomerically pure highly functionalised cyclopentane featuring 5 contiguous stereocenters.
Abstract Chiral molecules hold a mail position in Organic and Biological Chemistry, so pharmaceutical industry needs suitable strategies for drug synthesis. Moreover, Green Chemistry procedures are increasingly required order to avoid environment deterioration. Catalytic synthesis, particular organocatalysis, thus continuously expanding field. A survey of more recent researches involving chiral imidazolidinones is here presented, with focus on immobilized catalytic systems.