A5056536653- Asymmetric Hydrogenation and Catalysis
- Nanomaterials for catalytic reactions
- Radical Photochemical Reactions
- Chemical Synthesis and Reactions
- Sulfur-Based Synthesis Techniques
- Innovative Microfluidic and Catalytic Techniques Innovation
- Synthetic Organic Chemistry Methods
- Asymmetric Synthesis and Catalysis
- Ionic liquids properties and applications
- Ammonia Synthesis and Nitrogen Reduction
- Organoboron and organosilicon chemistry
- Synthesis and Catalytic Reactions
- Fluorine in Organic Chemistry
- Carbohydrate Chemistry and Synthesis
- Inorganic Fluorides and Related Compounds
- Catalytic C–H Functionalization Methods
- Oxidative Organic Chemistry Reactions
University of Milan
2020-2025
Mylan (South Africa)
2020
Lactam rings are essential structural motifs in organic chemistry, widely present natural products and clinically important drugs, such as antibiotics antiepileptics. Existing methods for synthesizing N‐functionalized lactams often require harsh conditions, toxic reagents, or complex catalytic systems. Here, we report a mild efficient photochemical approach generating N‐centered radicals, enabling straightforward N‐heteroarylation of lactams. This versatile method enables the synthesis range...
The catalytic enantioselective reduction of β,β-disubstituted nitroalkenes was performed in deep eutectic solvents, avoiding the use volatile organic compounds (VOCs) as reaction medium.The desired enantioenriched nitroalkanes were obtained high yields and enantiomeric excesses, up to 90%, by a metal-free, hydrogen bond-mediated methodology, with convenient experimental protocol that could be successfully applied gram-scale reaction.
Abstract The organophotoredox catalytic enantioselective addition of N ‐acyl radicals to aldehydes, afford enantioenriched 1,2 aminoalcohols was studied. Under the best conditions, in batch, product isolated up 52 % yield and 85 e.e ., using a low cost commercially available chiral imidazolidinone as organocatalyst. reaction then studied flow, exploring different experimental setups photoreactors. Although modest yields were obtained, in‐flow process afforded higher productivities (up 60...
Abstract The immobilization of Rose Bengal onto Merrifield resin and its application in the light‐driven metal‐free thiocyanation azaheterocycles continuo were investigated. supported photocatalyst was used batch reactions under heterogeneous conditions, with different azaheterocycles, proved to efficiently promote reaction. Its recovery recycle also demonstrated for up four times. resin‐supported then employed continuous flow affording thiocyanate functionalized higher space‐time‐yields...
Deep eutectic solvents (DESs) have gained attention as green and safe well economically environmentally sustainable alternative to the traditional organic solvents. Here, we report combination of an atom-economic, very convenient inexpensive reagent, such BH 3 NH , with bio-based mixtures biorenewable in synthesis nitroalkanes, valuable precursors amines. A variety nitrostyrenes alkyl-substituted nitroalkenes, including α- β-substituted nitroolefins, were chemoselectively reduced atom...
Abstract Nitrogen-centered radicals (NCRs) have been known in the literature since beginning of 1900s, but only with spread photoredox catalysis, and particular visible-light-mediated radical processes, has nitrogen-radical chemistry become more accessible via situ generation such under mild conditions. Historically, unlike their carbon counterparts, nitrogen were not utilized widely academia or industry due to a lack efficient strategies for production. Nowadays, NCRs are established, this...
Abstract Ammonia borane (AB) has been successfully employed in the reduction of nitroalkenes. A variety nitrostyrenes and alkyl-substituted nitroalkenes were chemoselectively reduced to corresponding nitroalkanes, short reaction time, with an atom-economic, simple experimental procedure that also works α- β-substituted nitroolefins.
The development of new and efficient methods, reagents, catalysts for the introduction fluorine atoms or fluorinated moieties in molecular scaffolds has become a topic paramount importance organic synthesis. In this framework, incorporation SCF3 group into molecule often led to beneficial effects on drug’s metabolic stability bioavailability. Here we report our studies aimed stereoselective synthesis chiral α-SCF3-β−ketoesters featuring tetrasubstituted stereocenter. use auxiliary was...
Abstract Chiral molecules hold a mail position in Organic and Biological Chemistry, so pharmaceutical industry needs suitable strategies for drug synthesis. Moreover, Green Chemistry procedures are increasingly required order to avoid environment deterioration. Catalytic synthesis, particular organocatalysis, thus continuously expanding field. A survey of more recent researches involving chiral imidazolidinones is here presented, with focus on immobilized catalytic systems.