About
Contact & Profiles
A5005267872
Research Areas
- CRISPR and Genetic Engineering
- Evolution and Genetic Dynamics
- Bacterial Genetics and Biotechnology
- Cardiomyopathy and Myosin Studies
- RNA and protein synthesis mechanisms
- Pluripotent Stem Cells Research
- Muscle Physiology and Disorders
Duke University
2019-2025
University of Colorado Boulder
2018
10.1038/s41587-019-0235-7
article
EN
Nature Biotechnology
2019-09-23
The ever-increasing threat of multi-drug resistant bacteria, a shrinking antibiotic pipeline, and the innate ability microorganisms to adapt necessitates long-term strategies slow evolution resistance. Here we develop an approach, dubbed Controlled Hindrance Adaptation OrganismS or CHAOS, involving induction epistasis between gene perturbations deter adaption. We construct combinatorial library multiplexed, deactivated CRISPR-Cas9 devices systematically perturb expression in Escherichia...
10.1038/s42003-018-0135-2
article
EN
cc-by
Communications Biology
2018-08-28
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