A5071542506- Cardiac electrophysiology and arrhythmias
- Nicotinic Acetylcholine Receptors Study
- Photoreceptor and optogenetics research
- Receptor Mechanisms and Signaling
- Ion channel regulation and function
- Biological Activity of Diterpenoids and Biflavonoids
- Medicinal plant effects and applications
- Cardiac Fibrosis and Remodeling
- Cardiovascular Effects of Exercise
- Photochromic and Fluorescence Chemistry
- Connexins and lens biology
Centre National de la Recherche Scientifique
2020-2025
Nantes Université
2020-2025
Inserm
2023-2025
Institut du Thorax
2023-2025
Chimie et Interdisciplinarité, Synthèse, Analyse, Modélisation
2020
Abstract The long QT syndrome type 3 (LQT3) is a cardiac channelopathy caused by gain-of-function mutations in the SCN5A gene, encoding sodium channel Na v 1.5. As 1.5 expressed cardiomyocytes but also fibroblasts, we investigated whether LQT3-causing p.ΔQKP1507-1509 (ΔQKP) mutation alters fibroblast phenotype. Primary cultured ventricular fibroblasts from Scn5a +/ΔQKP knock-in mice showed increased proliferation, survival, expression of transforming growth factor-β (TGF-β) and activation...
◼ photochemotherapy potassium channels zebrafish
Nav1.1 is an important pharmacological target as this voltage-gated sodium channel involved in neurological and cardiac syndromes. Channel activators are actively sought to try compensate for haploinsufficiency several of these pathologies. Herein we used a natural source new peptide compounds active on ion channels screened drugs capable inhibit inactivation way decreased function. We discovered that JzTx-34 highly subsequently performed full structure-activity relationship investigation...
Abstract RATIONALE Cardiac rhythm, conduction and synchronization of electrical activity require the coordinated action different types ion channels that differ according to transmural regional specificities. Classical pharmacology affects these in a non-regionalized way which explains why treating arrhythmias, often occur specific foci, has limited efficacy addition negative side-effects on non-targeted organs. Photopharmacology is an emergent technology potential counteract all aspects...