A5034045832- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Cannabis and Cannabinoid Research
- Diet, Metabolism, and Disease
- Pancreatic function and diabetes
- Liver Diseases and Immunity
- HIV/AIDS drug development and treatment
- Viral-associated cancers and disorders
- Helicobacter pylori-related gastroenterology studies
- Liver Disease and Transplantation
- Systemic Lupus Erythematosus Research
- Immunodeficiency and Autoimmune Disorders
- HIV/AIDS Research and Interventions
- Diabetes and associated disorders
University of Campania "Luigi Vanvitelli"
2013-2018
University of Naples Federico II
2013-2016
A common non-synonymous polymorphism, E167K, in transmembrane six superfamily member 2 (TM6SF2) gene has been recently associated with an increased hepatic triglyceride content, dyslipidemia and liver fibrosis NAFLD patients. We investigated possible associations between the TM6SF2 variants lesions chronic hepatitis C.148 consecutive patients biopsy proven anti-HCV/HCV-RNA-positive hepatitis, naive for antiviral therapy, were genotyped E167K PNPLA3 I148M variants.The score of steatosis was...
The patatin-like phospholipase domain-containing 3 gene (PNPLA3) and the apolipoprotein C3 (APOC3) have been studied in relation to liver steatosis disease outcome. aim of this study was evaluate influence PNPLA3 p.I148M APOC3 rs2854116 rs2854117 polymorphisms on clinical histological presentation chronic hepatitis C an Italian population their relationship with viral anthropometric parameters. Patients (n = 166) entered receiving a clinical, histological, virological biochemical evaluation....
Summary This study evaluated the long‐term efficacy and safety of an 18‐month lamivudine prophylaxis in 68 HB sAg‐negative/anti– c‐positive patients with oncohaematological disease. All consecutive disease naïve for chemotherapy observed from April 2008 to December 2012 at 2 Hematology Units Naples were treated 18 months after stopping monitored sAg 1 3 during then every its discontinuation. During follow‐up, 13 (19.1%) died complications related their disease, (4%) showed a virological HBV...
To evaluate in anti-HCV-positive patients the clinical impact of rs35761398 variant CNR2 gene leading to substitution Gln (Q) codon 63 cannabinoid receptor 2 (CB2) with Arg (R).253 consecutive anti-HCV-/HCV-RNA-positive were enrolled, whom 53 HCV carriers persistently normal ALT (PNALT group) and 200 had a history steadily abnormal serum values (abnormal group). All naive for antiviral therapy screened polymorphism by TaqMan assay.Subjects PNALT group, compared those group older (58.5±12 vs....
Aims . This study is aimed at assessing the efficacy of an active search and treat strategy for HBV-infected subjects in endemic area (Campania, Italy). To do this, we created a cooperation bundle between 24 General Practitioners (GPs) 3 Hospital Liver Units (HLU). We assessed whether this improved detection HBV infection patients risk overall quality care, with aim reducing liver disease progression. Methods estimated that, among about 20,000 cared by GPs, approximately 280 unaware or...