A5055161416- Chemical Synthesis and Analysis
- Click Chemistry and Applications
- X-ray Diffraction in Crystallography
- Monoclonal and Polyclonal Antibodies Research
- Crystallization and Solubility Studies
- Advanced biosensing and bioanalysis techniques
- Supramolecular Self-Assembly in Materials
- Glycosylation and Glycoproteins Research
- RNA Interference and Gene Delivery
- Fluorine in Organic Chemistry
- Carbohydrate Chemistry and Synthesis
University of Bristol
2021
University of Copenhagen
2017-2020
Karlsruhe Institute of Technology
2015
Here we introduce linear 1,4-triazolopeptoids as a novel class of cell penetrating peptidomimetics suitable organ targeting molecular transporters bioactive cargo.
The 1,2,3-triazole moiety can be incorporated as a peptide bond bioisostere to provide protease resistance in peptidomimetics. Herein, we report the synthesis of peptidomimetic building blocks containing backbone-fluorinated 1,4-disubstituted moieties. Synthetic protocols for preparation various Xaa-Gly dipeptide surrogates form Xaa-ψ[triazole]-F2Gly were established, and selected examples introduced into endogenous opioid receptor ligand Leu-enkephalin model compound.
Peptidomimetic foldamers adopting well-defined three-dimensional structures while being stable toward proteolysis are of interest in biomedical research, chemical biology, and biomimetic materials science. Despite their backbone flexibility, β-peptoids containing N-( S)-1-(1-naphthyl)ethyl ( Ns1npe) side chains can fold into unique triangular prism-shaped helices. We report herein the successful introduction amino groups onto robustly folded β-peptoid helices by construction incorporation...
Both <italic>R</italic> and <italic>S</italic> enantiomers of Fmoc-protected amino acids bearing α-aryl substituents may be made on gram scale. Solid-phase synthesis leads to helical peptides unperturbed by the presence these additional groups.
We report the synthesis of a series bis-functionalized β-peptoid oligomers hexamer length. This was achieved by synthesizing and incorporating protected amino- or azido-functionalized chiral building blocks into precursor trimer segment coupling strategy. The resulting hexamers were readily elaborated to provide target compounds displaying amino groups, carboxy hydroxy triazolo-pyridines, which should enable metal ion binding. Analysis novel circular dichroism (CD) spectroscopy 1H-13C...
We report the synthesis of a series bis-functionalized <i>b</i>-peptoid oligomers hexamer length. This was achieved by synthesizing and incorporating protected amino- or azido-functionalized chiral building blocks into precursor trimer segment coupling strategy. The resulting hexamers were readily elaborated to provide target compounds displaying amino groups, carboxy hydroxy triazolo-pyridines, which should enable metal ion binding. Analysis novel CD spectroscopy HSQC NMR...
We report the synthesis of a series bis-functionalized b -peptoid oligomers hexamer length. This was achieved by synthesizing and incorporating protected amino- or azido-functionalized chiral building blocks into precursor trimer segment coupling strategy. The resulting hexamers were readily elaborated to provide target compounds displaying amino groups, carboxy hydroxy triazolo-pyridines, which should enable metal ion binding. Analysis novel CD spectroscopy HSQC NMR revealed robust helical...