A5073083242- Virus-based gene therapy research
- Herpesvirus Infections and Treatments
- CAR-T cell therapy research
- Organ Transplantation Techniques and Outcomes
- Immunotherapy and Immune Responses
- Bone and Joint Diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Poxvirus research and outbreaks
- Viral Infectious Diseases and Gene Expression in Insects
- Liver Disease Diagnosis and Treatment
- Toxin Mechanisms and Immunotoxins
- Hematological disorders and diagnostics
- Cancer, Hypoxia, and Metabolism
- Cancer Immunotherapy and Biomarkers
- Ginseng Biological Effects and Applications
- Liver Disease and Transplantation
- interferon and immune responses
- Cell death mechanisms and regulation
North South University
2024
Pusan National University
2019-2020
Yonsei University
2013-2015
Transglutaminase 2 (TG2), a cross-linking enzyme, is involved in drug resistance and the constitutive activation of nuclear factor kappa B (NF-κB). We investigated association non-small cell lung cancer (NSCLC) treatment efficacy with TG2 NF-κB expression 120 patients: 102 adenocarcinoma 18 other histologic types. All patients underwent surgery; 88 received adjuvant chemotherapy, 28 receiving platinum-based doublet chemotherapy as first-line 29 epidermal growth receptor (EGFR)-tyrosine...
Oncolytic viruses are a promising class of anti-tumor agents; however, concerns regarding uncontrolled viral replication have led to the development replication-controllable oncolytic vaccinia virus (OVV). The engineering involves replacing native thymidine kinase (VV-tk) gene, in Wyeth strain backbone, with herpes simplex (HSV-tk) which allows for control via ganciclovir (GCV, an antiviral/cytotoxic pro-drug). Adding wild-type HSV-tk gene might disrupt tumor selectivity VV-tk deleted OVVs;...
The bone is a common site for metastasis in hepatocellular carcinoma (HCC). However, marrow from HCC rarely reported, and its frequency unclear. Here we report rare case of that presented as bicytopenia originating without metastasis. A 58-year-old man was admitted investigation liver mass with extensive lymph node enlargement detected when examining his general weakness weight loss. Laboratory findings revealed anemia, thrombocytopenia, mild elevated enzymes, normal prothrombin time...
This study aimed to evaluate the efficacy and safety of emergency variceal ligation for prevention rebleeding in cirrhotic patients who are found on initial endoscopy have blood clots stomach but no actively bleeding esophageal gastric varices or stigmata.This included 28 underwent prophylactic EVL 41 an elective intervention between January 2009 June 2014. Clinical outcomes were analyzed, including rebleeding, 6-week mortality, rebleeding-free survival rates.The rate was higher than group...
The purpose of this study was to assess characteristics SJ-815, a novel oncolytic vaccinia virus lacking functional thymidine kinase-encoding TK gene, and instead, having two human transgenes: the IFNB1 that encodes interferon β1, CES2 carboxylesterase 2, which metabolizes prodrug, irinotecan, into cytotoxic SN-38.Viral replication dissemination SJ-815 were measured by plaque assay comet assay, respectively, compared backbone modified Western Reserve named WI. Tumor cytotoxicity (or mSJ-815,...
Viral replication of thymidine kinase deleted (tk−) vaccinia virus (VV) is attenuated in resting normal cells, enabling cancer selectivity, however, potency VV-tk− appears to be diminished cells. Previously, we found that wild-type herpes simplex (HSV)-tk (HSV-tk) disappeared most the recombinant VV after multiple screenings, and only a few containing naturally mutated HSV-tk remained stable. In this study, VV-tk western reserve (WR) was replaced by A167Y (HSV-tk418m), alter nucleoside...